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<221> VEGF-B mRNA<222> (1)..(1172)<400> 1gcgatgcggg cgcccccggc gggcggcccc ggcgggcacc atgagccctc tgctccgccg 60cctgctgctc gccgcactcc tgcagctggc ccccgcccag gcccctgtct cccagcctga120tgcccctggc caccagagga aagtggtgtc atggatagat gtgtatactc gcgctacctg180ccagccccgg gaggtggtgg tgcccttgac tgtggagctc atgggcaccg tggccaaaca240gctggtgccc agctgcgtga ctgtgcagcg ctgtggtggc tgctgccctg acgatggcct300ggagtgtgtg cccactgggc agcaccaagt ccggatgcag atcctcatga tccggtaccc360gagcagtcag ctgggggaga tgtccctgga agaacacagc cagtgtgaat gcagacctaa420
aaaaaaggac agtgctgtga agccagacag ggctgccact ccccaccacc gtccccagcc 480ccgttctgtt ccgggctggg actctgcccc cggagcaccc tccccagctg acatcaccca 540tcccactcca gccccaggcc cctctgccca cgctgcaccc agcaccacca gcgccctgac 600ccccggacct gccgctgccg ctgccgacgc cgcagcttcc tccgttgcca agggcggggc 660ttagagctca acccagacac ctgcaggtgc cggaagctgc gaaggtgaca catggctttt 720cagactcagc agggtgactt gcctcagagg ctatatccca gtgggggaac aaagaggagc 780ctggtaaaaa acagccaagc ccccaagacc tcagcccagg cagaagctgc tctaggacct 840gggcctctca gagggctctt ctgccatccc ttgtctccct gaggccatca tcaaacagga 900cagagttgga agaggagact gggaggcagc aagaggggtc acataccagc tcaggggaga 960atggagtact gtctcagttt ctaaccactc tgtgcaagta agcatcttac aactggctct1020tcctcccctc actaagaaga cccaaacctc tgcataatgg gatttgggct ttggtacaag1080aactgtgacc cccaaccctg ataaaagaga tggaaggaaa aaaaaaaaaa aaaaaaaaaa1140aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa 1172<210> 2<211> 207<212> PRT<213> Homo sapiens<220>
<221> VEGF-B¶àëÄÐòÁÐ<222> (1)..(207)
<400> 2Met Ser Pro Leu Leu Arg Arg Leu Leu Leu Ala Ala Leu Leu Gln Leu1 5 10 15Ala Pro Ala Gln Ala Pro Val Ser Gln Pro Asp Ala Pro Gly His Gln20 25 30Arg Lys Val Val Ser Trp Ile Asp Val Tyr Thr Arg Ala Thr Cys Gln35 40 45Pro Arg Glu Val Val Val Pro Leu Thr Val Glu Leu Met Gly Thr Val50 55 60Ala Lys Gln Leu Val Pro Ser Cys Val Thr Val Gln Arg Cys Gly Gly65 70 75 80Cys Cys Pro Asp Asp Gly Leu Glu Cys Val Pro Thr Gly Gln His Gln85 90 95Val Arg Met Gln Ile Leu Met Ile Arg Tyr Pro Ser Ser Gln Leu Gly100 105 110Glu Met Ser Leu Glu Glu His Ser Gln Cys Glu Cys Arg Pro Lys Lys115 120 125Lys Asp Ser Ala Val Lys Pro Asp Arg Ala Ala Thr Pro His His Arg130 135 140Pro Gln Pro Arg Ser Val Pro Gly Trp Asp Ser Ala Pro Gly Ala Pro145 150 155 160Ser Pro Ala Asp Ile Thr His Pro Thr Pro Ala Pro Gly Pro Ser Ala165 170 175
His Ala Ala Pro Ser Thr Thr Ser Ala Leu Thr Pro Gly Pro Ala Ala180 185 190Ala Ala Ala Asp Ala Ala Ala Ser Ser Val Ala Lys Gly Gly Ala195 200 205<210> 3<211> 809<212> DNA<213> Homo sapiens<220>
<221> ÔØÖ¬µ°°×D mRNA<222> (1)..(809)<400> 3atgcctgtct tcatcttgaa agaaaagctc caggtccctt ctccagccac ccagccccaa 60gatggtgatg ctgctgctgc tgctttccgc actggctggc ctcttcggtg cggcagaggg120acaagcattt catcttggga agtgccccaa tcctccggtg caggagaatt ttgacgtgaa180taagtatctc ggaagatggt acgaaattga gaagatccca acaacctttg agaatggacg240ctgcatccag gccaactact cactaatgga aaacggaaag atcaaagtgt taaaccagga300gttgagagct gatggaactg tgaatcaaat cgaaggtgaa gccaccccag ttaacctcac360agagcctgcc aagctggaag ttaagttttc ctggtttatg ccatcggcac cgtactggat420cctggccacc gactatgaga actatgccct cgtgtattcc tgtacctgca tcatccaact480ttttcacgtg gattttgctt ggatcttggc aagaaaccct aatctccctc cagaaacagt540ggactctcta aaaaatatcc tgacttctaa taacattgat gtcaagaaaa tgacggtcac600
agaccaggtg aactgcccca agctctcgta accaggttct acagggaggc tgcacccact660ccatgttact tctgcttcgc tttcccctac cccacccccc cccataaaga caaaccaatc720aaccacgaca aaggaagttg acctaaacat gtaaccatgc cctaccctgt taccttgcta780gctgcaaaat aaacttgttg ctgacctgc 809<210> 4<211> 189<212> PRT<213> Homo sapiens<220>
<221> ÔØÖ¬µ°°×D¶àëÄÐòÁÐ<222> (1)..(189)<400> 4Met Val Met Leu Leu Leu Leu Leu Ser Ala Leu Ala Gly Leu Phe Gly15 10 15Ala Ala Glu Gly Gln Ala Phe His Leu Gly Lys Cys Pro Asn Pro Pro20 25 30Val Gln Glu Asn Phe Asp Val Asn Lys Tyr Leu Gly Arg Trp Tyr Glu35 40 45Ile Glu Lys Ile Pro Thr Thr Phe Glu Asn Gly Arg Cys Ile Gln Ala50 55 60Asn Tyr Ser Leu Met Glu Asn Gly Lys Ile Lys Val Leu Asn Gln Glu
65 70 75 80Leu Arg Ala Asp Gly Thr Val Asn Gln Ile Glu Gly Glu Ala Thr Pro85 90 95Val Asn Leu Thr Glu Pro Ala Lys Leu Glu Val Lys Phe Ser Trp Phe100 105 110Met Pro Ser Ala Pro Tyr Trp Ile Leu Ala Thr Asp Tyr Glu Asn Tyr115 120 125Ala Leu Val Tyr Ser Cys Thr Cys Ile Ile Gln Leu Phe His Val Asp130 135 140Phe Ala Trp Ile Leu Ala Arg Asn Pro Asn Leu Pro Pro Glu Thr Val145 150 155 160Asp Ser Leu Lys Asn Ile Leu Thr Ser Asn Asn Ile Asp Val Lys Lys165 170 175Met Thr Val Thr Asp Gln Val Asn Cys Pro Lys Leu Ser180 185<210> 5<211> 4040<212> DNA<213> Homo sapiens<220>
<221> Í­µ¥°·Ñõ»¯Ã¸mRNA<222> (1)..(4040)
<400> 5gtccttccca cccttagtcc caggcatctg actaccggga acctcagcca gagtccggga 60gccccccacc ccgtccagga gccaacagag cccccgtctt gctggcgtga gaatacattg120ctctcctttg gttgaatcag ctgtccctct tcgtgggaaa atgaaccaga agacaatcct180cgtgctcctc attctggccg tcatcaccat ctttgccttg gtttgtgtcc tgctggtggg240caggggtgga gatgggggtg aacccagcca gcttccccat tgcccctctg tatctcccag300tgcccagcct tggacacacc ctggccagag ccagctgttt gcagacctga gccgagagga360gctgacggct gtgatgcgct ttctgaccca gcggctgggg ccagggctgg tggatgcagc420ccaggcccgg ccctcggaca actgtgtctt ctcagtggag ttgcagctgc ctcccaaggc480tgcagccctg gctcacttgg acagggggag ccccccacct gcccgggagg cactggccat540cgtcttcttt ggcaggcaac cccagcccaa cgtgagtgag ctggtggtgg ggccactgcc600tcacccctcc tacatgcggg acgtgactgt ggagcgtcat ggaggccccc tgccctatca660ccgacgcccc gtgctgttcc aagagtacct ggacatagac cagatgatct tcaacagaga720gctgccccag gcttctgggc ttctccacca ctgttgcttc tacaagcacc ggggacggaa780cctggtgaca atgaccacgg ctccccgtgg tctgcaatca ggggaccggg ccacctggtt840tggcctctac tacaacatct cgggcgctgg gttcttcctg caccacgtgg gcttggagct900gctagtgaac cacaaggccc ttgaccctgc ccgctggact atccagaagg tgttctatca960aggccgctac tacgacagcc tggcccagct ggaggcccag tttgaggccg gcctggtgaa 1020tgtggtgctg atcccagaca atggcacagg tgggtcctgg tccctgaagt cccctgtgcc 1080cccgggtcca gctccccctc tacagttcta tccccaaggc ccccgcttca gtgtccaggg 1140aagtcgagtg gcctcctcac tgtggacttt ctcctttggc ctcggagcat tcagtggccc 1200aaggatcttt gacgttcgct tccaaggaga aagactagtt tatgagataa gcctccaaga 1260ggccttggcc atctatggtg gaaattcccc agcagcaatg acgacccgct atgtggatgg 1320aggctttggc atgggcaagt acaccacgcc cctgacccgt ggggtggact gcccctactt 1380
ggccacctac gtggactggc acttcctttt ggagtcccag gcccccaaga caatacgtga1440tgccttttgt gtgtttgaac agaaccaggg cctccccctg cggcgacacc actcagatct1500ctactcgcac tactttgggg gtcttgcgga aacggtgctg gtcgtcagat ctatgtccac1560cttgctcaac tatgactatg tgtgggatac ggtcttccac cccagtgggg ccatagaaat1620acgattctat gccacgggct acatcagctc ggcattcctc tttggtgcta ctgggaagta1680cgggaaccaa gtgtcagagc acaccctggg cacggtccac acccacagcg cccacttcaa1740ggtggatctg gatgtagcag gactggagaa ctgggtctgg gccgaggata tggtctttgt1800ccccatggct gtgccctgga gccctgagca ccagctgcag aggctgcagg tgacccggaa1860gctgctggag atggaggagc aggccgcctt cctcgtggga agcgccaccc ctcgctacct1920gtacctggcc agcaaccaca gcaacaagtg gggtcacccc cggggctacc gcatccagat1980gctcagcttt gctggagagc cgctgcccca aaacagctcc atggcgagag gcttcagctg2040ggagaggtac cagctggctg tgacccagcg gaaggaggag gagcccagta gcagcagcgt2100tttcaatcag aatgaccctt gggcccccac tgtggatttc agtgacttca tcaacaatga2160gaccattgct ggaaaggatt tggtggcctg ggtgacagct ggttttctgc atatcccaca2220tgcagaggac attcctaaca cagtgactgt ggggaacggc gtgggcttct tcctccgacc2280ctataacttc tttgacgaag acccctcctt ctactctgcc gactccatct acttccgagg2340ggaccaggat gctggggcct gcgaggtcaa ccccctagct tgcctgcccc aggctgctgc2400ctgtgccccc gacctccctg ccttctccca cgggggcttc tctcacaact aggcggtcct2460gggatggggc atgtggccaa gggctccagg gccagggtgt gagggatggg gagcagctgg2520gcactgggcc ggcagcctgg ttccctcttt cctgtgccag gactctcttt cttccactac2580cctccctcgc atccgcctct gagccaggag cctcctgacc ctgtgatgcc tgacacaggg2640gacactgaac cttgttgatg ccagctgtac tgagttctca tccacagagg ccaggcatgg2700cccagcctgg agccgtggcc gagggcttcc ctagatggtt ccctttgttg ctgtctggct2760ttcccgaatc tttttaggcc acctccaagg actctaaaag ggggctattc cctggagacc2820
ccagagtagg gttgccagtc ctgcaagtcc atagctgagc tggaaaggat gcttctgctc2880acattccctc tcatccaggt cctttccttc tcgtcttcct ctctctcacc tacttcctcc2940tcctcctcct gttcctgcct tctcttctat cctgcaattt ctcccgaatc ctgaggggat3000atccctatgt cccagcccct ggtactcccc cagccctcag ttttcagtca agttccgtct3060cctctccagc cctatggaag tctcaaggtc acgggacccc taatcagagt ggccaatccc3120tgtgtgtcgt tcccttgtgt ctgttgctta ttgggagtag gagttgctcc tacccctgtc3180ctggggctgg gtgtgtttca ggacagctgc ttctgtgcat ttgtgtctgc ctgcctcatg3240ctctctatag aggaggatgg tcatcgtgac agcagcagct caagttagca tttcaagtga3300tttgggggtg caatgataat gaagaatggc cattttgtac cagggctctg tattctgcaa3360cagcctgttt gggaggctgg agtggaaaca aagggtgggc atcaaagatg agaagccaaa3420gcccctacaa ctccagccac ccagccagga ggggctgtcc aatcacattc aggcatgcga3480atgagctggg ccctgggtga ggtgggggtc tggcctagtg gggaggggcc tggcctgggt3540ggggcagggc ctggcctggt ccaggcttgg gctccattcc catcactgct gtccctcctg3600aggtctggat tggggatggg gacaaagaaa tagcaagaga tgagaaacaa cagaaacttt3660tttctctaaa ggactggtta aatcaattct gatacagcct tacaatacaa tagtatgcag3720ctaaaaaata attgtatgtc tttatatact aatatgtaat aatcttcagg tgaaaaaggc3780aagccacaga aatgtgtwta gcgcacttcc catttgtgtt tcagaaagga gtagaatata3840aacacataat tgcttatgta tgcctattca gaataaatgg gtaacactga ttacttttgg3900gaggggaacc agtaggttga ggacaggaga gggaagggtc ttaacactta cacccttttg3960tacattttga attttgaacc atgtgactgt attacctatt caaaataaac aataaatggg4020cccaaaaaaa aaaaaaaaaa4040<210> 6<211> 763
<212> PRT<213> Homo sapiens<220>
<221> Í­µ¥°·Ñõ»¯Ã¸¶àëÄÐòÁÐ<222> (1)..(763)<400> 6Met Asn Gln Lys Thr Ile Leu Val Leu Leu Ile Leu Ala Val Ile Thr1 5 10 15Ile Phe Ala Leu Val Cys Val Leu Leu Val Gly Arg Gly Gly Asp Gly20 25 30Gly Glu Pro Ser Gln Leu Pro His Cys Pro Ser Val Ser Pro Ser Ala35 40 45Gln Pro Trp Thr His Pro Gly Gln Ser Gln Leu Phe Ala Asp Leu Ser50 55 60Arg Glu Glu Leu Thr Ala Val Met Arg Phe Leu Thr Gln Arg Leu Gly65 70 75 80Pro Gly Leu Val Asp Ala Ala Gln Ala Arg Pro Ser Asp Asn Cys Val85 90 95Phe Ser Val Glu Leu Gln Leu Pro Pro Lys Ala Ala Ala Leu Ala His100 105 110Leu Asp Arg Gly Ser Pro Pro Pro Ala Arg Glu Ala Leu Ala Ile Val115 120 125Phe Phe Gly Arg Gln Pro Gln Pro Asn Val Ser Glu Leu Val Val Gly
130 135 140Pro Leu Pro His Pro Ser Tyr Met Arg Asp Val Thr Val Glu Arg His145 150 155 160Gly Gly Pro Leu Pro Tyr His Arg Arg Pro Val Leu Phe Gln Glu Tyr165 170 175Leu Asp Ile Asp Gln Met Ile Phe Asn Arg Glu Leu Pro Gln Ala Ser180 185 190Gly Leu Leu His His Cys Cys Phe Tyr Lys His Arg Gly Arg Asn Leu195 200 205Val Thr Met Thr Thr Ala Pro Arg Gly Leu Gln Ser Gly Asp Arg Ala210 215 220Thr Trp Phe Gly Leu Tyr Tyr Asn Ile Ser Gly Ala Gly Phe Phe Leu225 230 235 240His His Val Gly Leu Glu Leu Leu Val Asn His Lys Ala Leu Asp Pro245 250 255Ala Arg Trp Thr Ile Gln Lys Val Phe Tyr Gln Gly Arg Tyr Tyr Asp260 265 270Ser Leu Ala Gln Leu Glu Ala Gln Phe Glu Ala Gly Leu Val Asn Val275 280 285Val Leu Ile Pro Asp Asn Gly Thr Gly Gly Ser Trp Ser Leu Lys Ser290 295 300Pro Val Pro Pro Gly Pro Ala Pro Pro Leu Gln Phe Tyr Pro Gln Gly305 310 315 320Pro Arg Phe Ser Val Gln Gly Ser Arg Val Ala Ser Ser Leu Trp Thr
325 330 335Phe Ser Phe Gly Leu Gly Ala Phe Ser Gly Pro Arg Ile Phe Asp Val340 345 350Arg Phe Gln Gly Glu Arg Leu Val Tyr Glu Ile Ser Leu Gln Glu Ala355 360 365Leu Ala Ile Tyr Gly Gly Asn Ser Pro Ala Ala Met Thr Thr Arg Tyr370 375 380Val Asp Gly Gly Phe Gly Met Gly Lys Tyr Thr Thr Pro Leu Thr Arg385 390 395 400Gly Val Asp Cys Pro Tyr Leu Ala Thr Tyr Val Asp Trp His Phe Leu405 410 415Leu Glu Ser Gln Ala Pro Lys Thr Ile Arg Asp Ala Phe Cys Val Phe420 425 430Glu Gln Asn Gln Gly Leu Pro Leu Arg Arg His His Ser Asp Leu Tyr435 440 445Ser His Tyr Phe Gly Gly Leu Ala Glu Thr Val Leu Val Val Arg Ser450 455 460Met Ser Thr Leu Leu Asn Tyr Asp Tyr Val Trp Asp Thr Val Phe His465 470 475 480Pro Ser Gly Ala Ile Glu Ile Arg Phe Tyr Ala Thr Gly Tyr Ile Ser485 490 495Ser Ala Phe Leu Phe Gly Ala Thr Gly Lys Tyr Gly Asn Gln Val Ser500 505 510Glu His Thr Leu Gly Thr Val His Thr His Ser Ala His Phe Lys Val
515 520 525Asp Leu Asp Val Ala Gly Leu Glu Asn Trp Val Trp Ala Glu Asp Met530 535 540Val Phe Val Pro Met Ala Val Pro Trp Ser Pro Glu His Gln Leu Gln545 550 555 560Arg Leu Gln Val Thr Arg Lys Leu Leu Glu Met Glu Glu Gln Ala Ala565 570575Phe Leu Val Gly Ser Ala Thr Pro Arg Tyr Leu Tyr Leu Ala Ser Asn580 585 590His Ser Asn Lys Trp Gly His Pro Arg Gly Tyr Arg Ile Gln Met Leu595 600 605Ser Phe Ala Gly Glu Pro Leu Pro Gln Asn Ser Ser Met Ala Arg Gly610 615 620Phe Ser Trp Glu Arg Tyr Gln Leu Ala Val Thr Gln Arg Lys Glu Glu625 630 635 640Glu Pro Ser Ser Ser Ser Val Phe Asn Gln Asn Asp Pro Trp Ala Pro645 650 655Thr Val Asp Phe Ser Asp Phe Ile Asn Asn Glu Thr Ile Ala Gly Lys660 665 670Asp Leu Val Ala Trp Val Thr Ala Gly Phe Leu His Ile Pro His Ala675 680 685Glu Asp Ile Pro Asn Thr Val Thr Val Gly Asn Gly Val Gly Phe Phe690 695 700Leu Arg Pro Tyr Asn Phe Phe Asp Glu Asp Pro Ser Phe Tyr Ser Ala
705 710 715 720Asp Ser Ile Tyr Phe Arg Gly Asp Gln Asp Ala Gly Ala Cys Glu Val725 730 735Asn Pro Leu Ala Cys Leu Pro Gln Ala Ala Ala Cys Ala Pro Asp Leu740 745 750Pro Ala Phe Ser His Gly Gly Phe Ser His Asn755 760<210> 7<211> 3948<212> DNA<213> Homo sapiens<220>
<221> ¶þëÄõ£ëÄøIV mRNA<222> (1)..(3948)<400> 7ctttcactgg caagagacgg agtcctgggt ttcagttcca gttgcctgcg gtgggctgtg 60tgagtttgcc aaagtcccct gccctctctg ggtctcggtt ccctcgcctg tccacgtgag120gttggaggag ctgaacgccg acgtcatttt tagctaagag ggagcagggt ccccgagtcg180ccggcccagg gtctgcgcat ccgaggccgc gcgccctttc ccctccccca cggctcctcc240gggccccgca ctctgcgccc cggctgccgc ccagcgccct acaccgccct cagggggccc300tcgcgggctc cccccggccg ggatgccagt gccccgcgcc acgcgcgcct gctcccgcgc360cgcctgccct gcagcctgcc cgcggcgcct ttatacccag cgggctcggc gctcactaat420gtttaactcg gggccgaaac ttgccagcgg cgagtgactc caccgcccgg agcagcggtg480
caggacgcgc gtctccgccg cccgcggtga cttctgcctg cgctccttct ctgaacgctc540acttccgagg agacgccgac gatgaagaca ccgtggaagg ttcttctggg actgctgggt600gctgctgcgc ttgtcaccat catcaccgtg cccgtggttc tgctgaacaa aggcacagat660gatgctacag ctgacagtcg caaaacttac actctaactg attacttaaa aaatacttat720agactgaagt tatactcctt aagatggatt tcagatcatg aatatctcta caaacaagaa780aataatatct tggtattcaa tgctgaatat ggaaacagct cagttttctt ggagaacagt840acatttgatg agtttggaca ttctatcaat gattattcaa tatctcctga tgggcagttt900attctcttag aatacaacta cgtgaagcaa tggaggcatt cctacacagc ttcatatgac960atttatgatt taaataaaag gcagctgatt acagaagaga ggattccaaa caacacacag 1020tgggtcacat ggtcaccagt gggtcataaa ttggcatatg tttggaacaa tgacatttat 1080gttaaaattg aaccaaattt accaagttac agaatcacat ggacggggaa agaagatata 1140atatataatg gaataactga ctgggtttat gaagaggaag tcttcagtgc ctactctgct 1200ctgtggtggt ctccaaacgg cactttttta gcatatgccc aatttaacga cacagaagtc 1260ccacttattg aatactcctt ctactctgat gagtcactgc agtacccaaa gactgtacgg 1320gttccatatc caaaggcagg agctgtgaat ccaactgtaa agttctttgt tgtaaataca 1380gactctctca gctcagtcac caatgcaact tccatacaaa tcactgctcc tgcttctatg 1440ttgatagggg atcactactt gtgtgatgtg acatgggcaa cacaagaaag aatttctttg 1500cagtggctca ggaggattca gaactattcg gtcatggata tttgtgacta tgatgaatcc 1560agtggaagat ggaactgctt agtggcacgg caacacattg aaatgagtac tactggctgg 1620gttggaagat ttaggccttc agaacctcat tttacccttg atggtaatag cttctacaag 1680atcatcagca atgaagaagg ttacagacac atttgctatt tccaaataga taaaaaagac 1740tgcacattta ttacaaaagg cacctgggaa gtcatcggga tagaagctct aaccagtgat 1800tatctatact acattagtaa tgaatataaa ggaatgccag gaggaaggaa tctttataaa 1860atccaactta gtgactatac aaaagtgaca tgcctcagtt gtgagctgaa tccggaaagg 1920
tgtcagtact attctgtgtc attcagtaaa gaggcgaagt attatcagct gagatgttcc1980ggtcctggtc tgcccctcta tactctacac agcagcgtga atgataaagg gctgagagtc2040ctggaagaca attcagcttt ggataaaatg ctgcagaatg tccagatgcc ctccaaaaaa2100ctggacttca ttattttgaa tgaaacaaaa ttttggtatc agatgatctt gcctcctcat2160tttgataaat ccaagaaata tcctctacta ttagatgtgt atgcaggccc atgtagtcaa2220aaagcagaca ctgtcttcag actgaactgg gccacttacc ttgcaagcac agaaaacatt2280atagtagcta gctttgatgg cagaggaagt ggttaccaag gagataagat catgcatgca2340atcaacagaa gactgggaac atttgaagtt gaagatcaaa ttgaagcagc cagacaattt2400tcaaaaatgg gatttgtgga caacaaacga attgcaattt ggggctggtc atatggaggg2460tacgtaacct caatggtcct gggatcggga agtggcgtgt tcaagtgtgg aatagccgtg2520gcgcctgtat cccggtggga gtactatgac tcagtgtaca cagaacgtta catgggtctc2580ccaactccag aagacaacct tgaccattac agaaattcaa cagtcatgag cagagctgaa2640aattttaaac aagttgagta cctccttatt catggaacag cagatgataa cgttcacttt2700cagcagtcag ctcagatctc caaagccctg gtcgatgttg gagtggattt ccaggcaatg2760tggtatactg atgaagacca tggaatagct agcagcacag cacaccaaca tatatatacc2820cacatgagcc acttcataaa acaatgtttc tctttacctt agcacctcaa aataccatgc2880catttaaagc ttattaaaac tcatttttgt tttcattatc tcaaaactgc actgtcaaga2940tgatgatgat ctttaaaata cacactcaaa tcaagaaact taaggttacc tttgttccca3000aatttcatac ctatcatctt aagtagggac ttctgtcttc acaacagatt attaccttac3060agaagtttga attatccggt cgggttttat tgtttaaaat catttctgca tcagctgctg3120aaacaacaaa taggaattgt ttttatggag gctttgcata gattccctga gcaggatttt3180aatctttttc taactggact ggttcaaatg ttgttctctt ctttaaaggg atggcaagat3240gtgggcagtg atgtcactag ggcagggaca ggataagagg gattagggag agaagatagc3300
agggcatggc tgggaaccca agtccaagca taccaacacg agcaggctac tgtcagctcc3360cctcggagaa gagctgttca cagccagact ggcacagttt tctgagaaag actattcaaa3420cagtctcagg aaatcaaata tgcaaagcac tgacttctaa gtaaaaccac agcagttgaa3480aagactccaa agaaatgtaa gggaaactgc cagcaacgca ggcccccagg tgccagttat3540ggctataggt gctacaaaaa cacagcaagg gtgatgggaa agcattgtaa atgtgctttt3600aaaaaaaaat actgatgttc ctagtgaaag aggcagcttg aaactgagat gtgaacacat3660cagcttgccc tgttaaaaga tgaaaatatt tgtatcacaa atcttaactt gaaggagtcc3720ttgcatcaat ttttcttatt tcatttcttt gagtgtctta attaaaagaa tattttaact3780tccttggact cattttaaaa aatggaacat aaaatacaat gttatgtatt attattccca3840ttctacatac tatggaattt ctcccagtca tttaataaat gtgccttcat tttttcagaa3900aaaaaaaaaa aaagtcagtg cttgcatact caaggagtct tatctaga 3948<210> 8<211> 766<212> PRT<213> Homo sapiens<220>
<221> ¶þëÄõ£ëÄøIV¶àëÄÐòÁÐ<222> (1)..(766)<400> 8Met Lys Thr Pro Trp Lys Val Leu Leu Gly Leu Leu Gly Ala Ala Ala1 5 10 15
Leu Val Thr Ile Ile Thr Val Pro Val Val Leu Leu Asn Lys Gly Thr20 25 30Asp Asp Ala Thr Ala Asp Ser Arg Lys Thr Tyr Thr Leu Thr Asp Tyr35 40 45Leu Lys Asn Thr Tyr Arg Leu Lys Leu Tyr Ser Leu Arg Trp Ile Ser50 55 60Asp His Glu Tyr Leu Tyr Lys Gln Glu Asn Asn Ile Leu Val Phe Asn65 70 75 80Ala Glu Tyr Gly Asn Ser Ser Val Phe Leu Glu Asn Ser Thr Phe Asp85 90 95Glu Phe Gly His Ser Ile Asn Asp Tyr Ser Ile Ser Pro Asp Gly Gln100 105 110Phe Ile Leu Leu Glu Tyr Asn Tyr Val Lys Gln Trp Arg His Ser Tyr115 120125Thr Ala Ser Tyr Asp Ile Tyr Asp Leu Asn Lys Arg Gln Leu Ile Thr130 135 140Glu Glu Arg Ile Pro Asn Asn Thr Gln Trp Val Thr Trp Ser Pro Val145 150 155 160Gly His Lys Leu Ala Tyr Val Trp Asn Asn Asp Ile Tyr Val Lys Ile165 170 175Glu Pro Asn Leu Pro Ser Tyr Arg Ile Thr Trp Thr Gly Lys Glu Asp180 185 190Ile Ile Tyr Asn Gly Ile Thr Asp Trp Val Tyr Glu Glu Glu Val Phe195 200 205
Ser Ala Tyr Ser Ala Leu Trp Trp Ser Pro Asn Gly Thr Phe Leu Ala210 215 220Tyr Ala Gln Phe Asn Asp Thr Glu Val Pro Leu Ile Glu Tyr Ser Phe225 230 235 240Tyr Ser Asp Glu Ser Leu Gln Tyr Pro Lys Thr Val Arg Val Pro Tyr245 250 255Pro Lys Ala Gly Ala Val Asn Pro Thr Val Lys Phe Phe Val Val Asn260 265 270Thr Asp Ser Leu Ser Ser Val Thr Asn Ala Thr Ser Ile Gln Ile Thr275 280 285Ala Pro Ala Ser Met Leu Ile Gly Asp His Tyr Leu Cys Asp Val Thr290 295 300Trp Ala Thr Gln Glu Arg Ile Ser Leu Gln Trp Leu Arg Arg Ile Gln305 310 315 320Asn Tyr Ser Val Met Asp Ile Cys Asp Tyr Asp Glu Ser Ser Gly Arg325 330 335Trp Asn Cys Leu Val Ala Arg Gln His Ile Glu Met Ser Thr Thr Gly340 345 350Trp Val Gly Arg Phe Arg Pro Ser Glu Pro His Phe Thr Leu Asp Gly355 360 365Asn Ser Phe Tyr Lys Ile Ile Ser Asn Glu Glu Gly Tyr Arg His Ile370 375 380Cys Tyr Phe Gln Ile Asp Lys Lys Asp Cys Thr Phe Ile Thr Lys Gly385390 395 400
Thr Trp Glu Val Ile Gly Ile Glu Ala Leu Thr Ser Asp Tyr Leu Tyr405 410 415Tyr Ile Ser Asn Glu Tyr Lys Gly Met Pro Gly Gly Arg Asn Leu Tyr420 425 430Lys Ile Gln Leu Ser Asp Tyr Thr Lys Val Thr Cys Leu Ser Cys Glu435 440 445Leu Asn Pro Glu Arg Cys Gln Tyr Tyr Ser Val Ser Phe Ser Lys Glu450 455 460Ala Lys Tyr Tyr Gln Leu Arg Cys Ser Gly Pro Gly Leu Pro Leu Tyr465 470 475 480Thr Leu His Ser Ser Val Asn Asp Lys Gly Leu Arg Val Leu Glu Asp485 490 495Asn Ser Ala Leu Asp Lys Met Leu Gln Asn Val Gln Met Pro Ser Lys500 505 510Lys Leu Asp Phe Ile Ile Leu Asn Glu Thr Lys Phe Trp Tyr Gln Met515 520 525Ile Leu Pro Pro His Phe Asp Lys Ser Lys Lys Tyr Pro Leu Leu Leu530 535 540Asp Val Tyr Ala Gly Pro Cys Ser Gln Lys Ala Asp Thr Val Phe Arg545 550 555 560Leu Asn Trp Ala Thr Tyr Leu Ala Ser Thr Glu Asn Ile Ile Val Ala565 570 575Ser Phe Asp Gly Arg Gly Ser Gly Tyr Gln Gly Asp Lys Ile Met His580 585 590
Ala Ile Asn Arg Arg Leu Gly Thr Phe Glu Val Glu Asp Gln Ile Glu595 600 605Ala Ala Arg Gln Phe Ser Lys Met Gly Phe Val Asp Asn Lys Arg Ile610 615 620Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Thr Ser Met Val Leu625 630 635 640Gly Ser Gly Ser Gly Val Phe Lys Cys Gly Ile Ala Val Ala Pro Val645 650 655Ser Arg Trp Glu Tyr Tyr Asp Ser Val Tyr Thr Glu Arg Tyr Met Gly660 665 670Leu Pro Thr Pro Glu Asp Asn Leu Asp His Tyr Arg Asn Ser Thr Val675 680 685Met Ser Arg Ala Glu Asn Phe Lys Gln Val Glu Tyr Leu Leu Ile His690 695 700Gly Thr Ala Asp Asp Asn Val His Phe Gln Gln Ser Ala Gln Ile Ser705 710 715 720Lys Ala Leu Val Asp Val Gly Val Asp Phe Gln Ala Met Trp Tyr Thr725 730 735Asp Glu Asp His Gly Ile Ala Ser Ser Thr Ala His Gln His Ile Tyr740 745 750Thr His Met Ser His Phe Ile Lys Gln Cys Phe Ser Leu Pro755 760 765
<210> 9<211> 6803<212> DNA<213> Homo sapiens<220>
<221> ³ÉÏËάϸ°ûÉú³¤Òò×Ó2 mRNA<222> (1)..(6803)<400> 9cggccccaga aaacccgagc gagtaggggg cggcgcgcag gagggaggag aactgggggc 60gcgggaggct ggtgggtgtc gggggtggag atgtagaaga tgtgacgccg cggcccggcg120ggtgccagat tagcggacgc gctgcccgcg gttgcaacgg gatcccgggc gctgcagctt180gggaggcggc tctccccagg cggcgtccgc ggagacaccc atccgtgaac cccaggtccc240gggccgccgg ctcgccgcgc accaggggcc ggcggacaga agagcggccg agcggctcga300ggctggggga ccgcgggcgc ggccgcgcgc tgccgggcgg gaggctgggg ggccggggcc360ggggccgtgc cccggagcgg gtcggaggcc ggggccgggg ccgggggacg gcggctcccc420gcgcggctcc agcggctcgg ggatcccggc cgggccccgc agggaccatg gcagccggga480gcatcaccac gctgcccgcc ttgcccgagg atggcggcag cggcgccttc ccgcccggcc540acttcaagga ccccaagcgg ctgtactgca aaaacggggg cttcttcctg cgcatccacc600ccgacggccg agttgacggg gtccgggaga agagcgaccc tcacatcaag ctacaacttc660aagcagaaga gagaggagtt gtgtctatca aaggagtgtg tgctaaccgt tacctggcta720tgaaggaaga tggaagatta ctggcttcta aatgtgttac ggatgagtgt ttcttttttg780aacgattgga atctaataac tacaatactt accggtcaag gaaatacacc agttggtatg840tggcactgaa acgaactggg cagtataaac ttggatccaa aacaggacct gggcagaaag900ctatactttt tcttccaatg tctgctaaga gctgatttta atggccacat ctaatctcat960
ttcacatgaa agaagaagta tattttagaa atttgttaat gagagtaaaa gaaaataaat1020gtgtatagct cagtttggat aattggtcaa acaatttttt atccagtagt aaaatatgta1080accattgtcc cagtaaagaa aaataacaaa agttgtaaaa tgtatattct cccttttata1140ttgcatctgc tgttacccag tgaagcttac ctagagcaat gatctttttc acgcatttgc1200tttattcgaa aagaggcttt taaaatgtgc atgtttagaa acaaaatttc ttcatggaaa1260tcatatacat tagaaaatca cagtcagatg tttaatcaat ccaaaatgtc cactatttct1320tatgtcattc gttagtctac atgtttctaa acatataaat gtgaatttaa tcaattcctt1380tcatagtttt ataattctct ggcagttcct tatgatagag tttataaaac agtcctgtgt1440aaactgctgg aagttcttcc acagtcaggt caattttgtc aaacccttct ctgtacccat1500acagcagcag cctagcaact ctgctggtga tgggagttgt attttcagtc ttcgccaggt1560cattgagatc catccactca catcttaagc attcttcctg gcaaaaattt atggtgaatg1620aatatggctt taggcggcag atgatataca tatctgactt cccaaaagct ccaggatttg1680tgtgctgttg ccgaatactc aggacggacc tgaattctga ttttatacca gtctcttcaa1740aaacttctcg aaccgctgtg tctcctacgt aaaaaaagag atgtacaaat caataataat1800tacactttta gaaactgtat catcaaagat tttcagttaa agtagcatta tgtaaaggct1860caaaacatta ccctaacaaa gtaaagtttt caatacaaat tctttgcctt gtggatatca1920agaaatccca aaatattttc ttaccactgt aaattcaaga agcttttgaa atgctgaata1980tttctttggc tgctacttgg aggcttatct acctgtacat ttttggggtc agctcttttt2040aacttcttgc tgctcttttt cccaaaaggt aaaaatatag attgaaaagt taaaacattt2100tgcatggctg cagttccttt gtttcttgag ataagattcc aaagaactta gattcatttc2160ttcaacaccg aaatgctgga ggtgtttgat cagttttcaa gaaacttgga atataaataa2220ttttataatt caacaaaggt tttcacattt tataaggttg atttttcaat taaatgcaaa2280tttgtgtggc aggattttta ttgccattaa catatttttg tggctgcttt ttctacacat2340ccagatggtc cctctaactg ggctttctct aattttgtga tgttctgtca ttgtctccca2400
aagtatttag gagaagccct ttaaaaagct gccttcctct accactttgc tggaaagctt2460cacaattgtc acagacaaag atttttgttc caatactcgt tttgcctcta tttttcttgt2520ttgtcaaata gtaaatgata tttgcccttg cagtaattct actggtgaaa aacatgcaaa2580gaagaggaag tcacagaaac atgtctcaat tcccatgtgc tgtgactgta gactgtctta2640ceatagactg tcttacccat cccctggata tgctcttgtt ttttccctct aatagctatg2700gaaagatgca tagaaagagt ataatgtttt aaaacataag gcattcatct gccatttttc2760aattacatgc tgacttccct tacaattgag atttgcccat aggttaaaca tggttagaaa2820caactgaaag cataaaagaa aaatctaggc cgggtgcagt ggctcatgcc tatattccct2880gcactttggg aggccaaagc aggaggatcg cttgagccca ggagttcaag accaacctgg2940tgaaaccccg tctctacaaa aaaacacaaa aaatagccag gcatggtggc gtgtacatgt3000ggtctcagat acttgggagg ctgaggtggg agggttgatc acttgaggct gagaggtcaa3060ggttgcagtg agccataatc gtgccactgc agtccagcct aggcaacaga gtgagacttt3120gtctcaaaaa aagagaaatt ttccttaata agaaaagtaa tttttactct gatgtgcaat3180acatttgtta ttaaatttat tatttaagat ggtagcacta gtcttaaatt gtataaaata3240tcccctaaca tgtttaaatg tccattttta ttcattatgc tttgaaaaat aattatgggg3300aaatacatgt ttgttattaa atttattatt aaagatagta gcactagtct taaatttgat3360ataacatctc ctaacttgtt taaatgtcca tttttattct ttatgcttga aaataaatta3420tggggatcct atttagctct tagtaccact aatcaaaagt tcggcatgta gctcatgatc3480tatgctgttt ctatgtcgtg gaagcaccgg atgggggtag tgagcaaatc tgccctgctc3540agcagtcacc atagcagctg actgaaaatc agcactgcct gagtagtttt gatcagttta3600acttgaatca ctaactgact gaaaattgaa tgggcaaata agtgcttttg tctccagagt3660atgcgggaga cccttccacc tcaagatgga tatttcttcc ccaaggattt caagatgaat3720tgaaattttt aatcaagata gtgtgcttta ttctgttgta ttttttatta ttttaatata3780ctgtaagcca aactgaaata acatttgctg ttttataggt ttgaagaaca taggaaaaac3840
taagaggttt tgtttttatt tttgctgatg aagagatatg tttaaatatg ttgtattgtt3900ttgtttagtt acaggacaat aatgaaatgg agtttatatt tgttatttct attttgttat3960atttaataat agaattagat tgaaataaaa tataatggga aataatctgc agaatgtggg4020tttcctggtg tttcctctga ctctagtgca ctgatgatct ctgataaggc tcagctgctt4080tatagttctc tggctaatgc agcagatact cttcctgcca gtggtaatac gattttttaa4140gaaggcagtt tgtcaatttt aatcttgtgg atacctttat actcttaggg tattatttta4200tacaaaagcc ttgaggattg cattctattt tctatatgac cctcttgata tttaaaaaac4260actatggata acaattcttc atttacctag tattatgaaa gaatgaagga gttcaaacaa4320atgtgtttcc cagttaacta gggtttactg tttgagccaa tataaatgtt taactgtttg4380tgatggcagt attcctaaag tacattgcat gttttcctaa atacagagtt taaataattt4440cagtaattct tagatgattc agcttcatca ttaagaatat cttttgtttt atgttgagtt4500agaaatgcct tcatatagac atagtctttc agacctctac tgtcagtttt catttctagc4560tgctttcagg gttttatgaa ttttcaggca aagctttaat ttatactaag cttaggaagt4620atggctaatg ccaacggcag tttttttctt cttaattcca catgactgag gcatatatga4680tctctgggta ggtgagttgt tgtgacaacc acaagcactt tttttttttt taaagaaaaa4740aaggtagtga atttttaatc atctggactt taagaaggat tctggagtat acttaggcct4800gaaattatat atatttggct tggaaatgtg tttttcttca attacatcta caagtaagta4860cagctgaaat tcagaggacc cataagagtt cacatgaaaa aaatcaattc atttgaaaag4920gcaagatgca ggagagagga agccttgcaa acctgcagac tgctttttgc ccaatataga4980ttgggtaagg ctgcaaaaca taagcttaat tagctcacat gctctgctct cacgtggcac5040cagtggatag tgtgagagaa ttaggctgta gaacaaatgg ccttctcttt cagcattcac5100accactacaa aatcatcttt tatatcaaca gaagaataag cataaactaa gcaaaaggtc5160aataagtacc tgaaaccaag attggctaga gatatatctt aatgcaatcc attttctgat5220ggattgttac gagttggcta tataatgtat gtatggtatt ttgatttgtg taaaagtttt5280
aaaaatcaag ctttaagtac atggacattt ttaaataaaa tatttaaaga caatttagaa5340aattgcctta atatcattgt tggctaaata gaatagggga catgcatatt aaggaaaagg5400tcatggagaa ataatattgg tatcaaacaa atacattgat ttgtcatgat acacattgaa5460tttgatccaa tagtttaagg aataggtagg aaaatttggt ttctattttt cgatttcctg5520taaatcagtg acataaataa ttcttagctt attttatatt tccttgtctt aaatactgag5580ctcagtaagt tgtgttaggg gattatttct cagttgagac tttcttatat gacattttac5640tatgttttga cttcctgact attaaaaata aatagtagaa acaattttca taaagtgaag5700aattatataa tcactgcttt ataactgact ttattatatt tatttcaaag ttcatttaaa5760ggctactatt catcctctgt gatggaatgg tcaggaattt gttttctcat agtttaattc5820caacaacaat attagtcgta tccaaaataa cctttaatgc taaactttac tgatgtatat5880ccaaagcttc tccttttcag acagattaat ccagaagcag tcataaacag aagaataggt5940ggtatgttcc taatgatatt atttctacta atggaataaa ctgtaatatt agaaattatg6000ctgctaatta tatcagctct gaggtaattt ctgaaatgtt cagactcagt cggaacaaat6060tggaaaattt aaatttttat tcttagctat aaagcaagaa agtaaacaca ttaatttcct6120caacattttt aagccaatta aaaatataaa agatacacac caatatcttc ttcaggctct6180gacaggcctc ctggaaactt ccacatattt ttcaactgca gtataaagtc agaaaataaa6240gttaacataa ctttcactaa cacacacata tgtagatttc acaaaatcca cctataattg6300gtcaaagtgg ttgagaatat attttttagt aattgcatgc aaaatttttc tagcttccat6360cctttctccc tcgtttcttc tttttttggg ggagctggta actgatgaaa tcttttccca6420ccttttctct tcaggaaata taagtggttt tgtttggtta acgtgataca ttctgtatga6480atgaaacatt ggagggaaac atctactgaa tttctgtaat ttaaaatatt ttgctgctag6540ttaactatga acagatagaa gaatcttaca gatgctgcta taaataagta gaaaatataa6600atttcatcac taaaatatgc tattttaaaa tctatttcct atattgtatt tctaatcaga6660tgtattactc ttattatttc tattgtatgt gttaatgatt ttatgtaaaa atgtaattgc6720
ttttcatgag tagtatgaat aaaattgatt agtttgtgtt ttcttgtctc ccgaaaaaaa6780aaaaaaaaaa aaaaaaaaaa aaa6803<210> 10<211> 288<212> PRT<213> Homo sapiens<220>
<221> ³ÉÏËάϸ°ûÉú³¤Òò×Ó2¶àëÄÐòÁÐ<222> (1)..(288)<400> 10Met Val Gly Val Gly Gly Gly Asp Val Glu Asp Val Thr Pro Arg Pro1 5 10 15Gly Gly Cys Gln Ile Ser Gly Arg Ala Ala Arg Gly Cys Asn Gly Ile20 25 30Pro Gly Ala Ala Ala Trp Glu Ala Ala Leu Pro Arg Arg Arg Pro Arg35 40 45Arg His Pro Ser Val Asn Pro Arg Ser Arg Ala Ala Gly Ser Pro Arg50 55 60Thr Arg Gly Arg Arg Thr Glu Glu Arg Pro Ser Gly Ser Arg Leu Gly65 70 75 80Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly Gly Arg85 90 95
Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg Gly Arg100 105 110Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser Arg Pro115 120 125Gly Pro Ala Gly Thr Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala130 135 140Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys145 150 155 160Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile165 170 175His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His180 185 190Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys195 200 205Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu210 215 220Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu225 230 235 240Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp245 250 255Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr260 265 270Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser275 280 285
<210> 11<211> 5826<212> DNA<213> Homo sapiens<220>
<221> ѪС°å·´Ó¦µ°°×2 mRNA<222> (1)..(5826)<400> 11gaggaggaga cggcatccag tacagagggg ctggacttgg acccctgcag cagccctgca 60caggagaagc ggcatataaa gccgcgctgc ccgggagccg ctcggccacg tccaccggag120catcctgcac tgcagggccg gtctctcgct ccagcagagc ctgcgccttt ctgactcggt180ccggaacact gaaaccagtc atcactgcat ctttttggca aaccaggagc tcagctgcag240gaggcaggat ggtctggagg ctggtcctgc tggctctgtg ggtgtggccc agcacgcaag300ctggtcacca ggacaaagac acgaccttcg accttttcag tatcagcaac atcaaccgca360agaccattgg cgccaagcag ttccgcgggc ccgaccccgg cgtgccggct taccgcttcg420tgcgctttga ctacatccca ccggtgaacg cagatgacct cagcaagatc accaagatca480tgcggcagaa ggagggcttc ttcctcacgg cccagctcaa gcaggacggc aagtccaggg540gcacgctgtt ggctctggag ggccccggtc tctcccagag gcagttcgag atcgtctcca600acggccccgc ggacacgctg gatctcacct actggattga cggcacccgg catgtggtct660ccctggagga cgtcggcctg gctgactcgc agtggaagaa cgtcaccgtg caggtggctg720gcgagaccta cagcttgcac gtgggctgcg acctcataga cagcttcgct ctggacgagc780ccttctacga gcacctgcag gcggaaaaga gccggatgta cgtggccaaa ggctctgcca840gagagagtca cttcaggggt ttgcttcaga acgtccacct agtgtttgaa aactctgtgg900
aagatattct aagcaagaag ggttgccagc aaggccaggg agctgagatc aacgccatca 960gtgagaacac agagacgctg cgcctgggtc cgcatgtcac caccgagtac gtgggcccca1020gctcggagag gaggcccgag gtgtgcgaac gctcgtgcga ggagctggga aacatggtcc1080aggagctctc ggggctccac gtcctcgtga accagctcag cgagaacctc aagagagtgt1140cgaatgataa ccagtttctc tgggagctca ttggtggccc tcctaagaca aggaacatgt1200cagcttgctg gcaggatggc cggttctttg cggaaaatga aacgtgggtg gtggacagct1260gcaccacgtg tacctgcaag aaatttaaaa ccatttgcca ccaaatcacc tgcccgcctg1320caacctgcgc cagtccatcc tttgtggaag gcgaatgctg cccttcctgc ctccactcgg1380tggacggtga ggagggctgg tctccgtggg cagagtggac ccagtgctcc gtgacgtgtg1440gctctgggac ccagcagaga ggccggtcct gtgacgtcac cagcaacacc tgcttggggc1500cctccatcca gacacgggct tgcagtctga gcaagtgtga cacccgcatc cggcaggacg1560gcggctggag ccactggtca ccttggtctt catgctctgt gacctgtgga gttggcaata1620tcacacgcat ccgtctctgc aactccccag tgccccagat ggggggcaag aattgcaaag1680ggagtggccg ggagaccaaa gcctgccagg gcgccccatg cccaatcgat ggccgctgga1740gcccctggtc cccgtggtcg gcctgcactg tcacctgtgc cggtgggatc cgggagcgca1800cccgggtctg caacagccct gagcctcagt acggagggaa ggcctgcgtg ggggatgtgc1860aggagcgtca gatgtgcaac aagaggagct gccccgtgga tggctgttta tccaacccct1920gcttcccggg agcccagtgc agcagcttcc ccgatgggtc ctggtcatgc ggctcctgcc1980ctgtgggctt cttgggcaat ggcacccact gtgaggacct ggacgagtgt gccctggtcc2040ccgacatctg cttctccacc agcaaggtgc ctcgctgtgt caacactcag cctggcttcc2100actgcctgcc ctgcccgccc cgatacagag ggaaccagcc cgtcggggtc ggcctggaag2160cagccaagac ggaaaagcaa gtgtgtgagc ccgaaaaccc atgcaaggac aagacacaca2220actgccacaa gcacgcggag tgcatctacc tgggccactt cagcgacccc atgtacaagt2280gcgagtgcca gacaggctac gcgggcgacg ggctcatctg cggggaggac tcggacctgg2340
acggctggcc caacctcaat ctggtctgcg ccaccaacgc cacctaccac tgcatcaagg2400ataactgccc ccatctgcca aattctgggc aggaagactt tgacaaggac gggattggcg2460atgcctgtga tgatgacgat gacaatgacg gtgtgaccga tgagaaggac aactgccagc2520tcctcttcaa tccccgccag gctgactatg acaaggatga ggttggggac cgctgtgaca2580actgccctta cgtgcacaac cctgcccaga tcgacacaga caacaatgga gagggtgacg2640cctgctccgt ggacattgat ggggacgatg tcttcaatga acgagacaat tgtccctacg2700tctacaacac tgaccagagg gacacggatg gtgacggtgt gggggatcac tgtgacaact2760gccccctggt gcacaaccct gaccagaccg acgtggacaa tgaccttgtt ggggaccagt2820gtgacaacaa cgaggacata gatgacgacg gccaccagaa caaccaggac aactgcccct2880acatctccaa cgccaaccag gctgaccatg acagagacgg ccagggcgac gcctgtgacc2940ctgatgatga caacgatggc gtccccgatg acagggacaa ctgccggctt gtgttcaacc3000cagaccagga ggacttggac ggtgatggac ggggtgatat ttgtaaagat gattttgaca3060atgacaacat cccagatatt gatgatgtgt gtcctgaaaa caatgccatc agtgagacag3120acttcaggaa cttccagatg gtccccttgg atcccaaagg gaccacccaa attgatccca3180actgggtcat tcgccatcaa ggcaaggagc tggttcagac agccaactcg gaccccggca3240tcgctgtagg ttttgacgag tttgggtctg tggacttcag tggcacattc tacgtaaaca3300ctgaccggga cgacgactat gccggcttcg tctttggtta ccagtcaagc agccgcttct3360atgtggtgat gtggaagcag gtgacgcaga cctactggga ggaccagccc acgcgggcct3420atggctactc cggcgtgtcc ctcaaggtgg tgaactccac cacggggacg ggcgagcacc3480tgaggaacgc gctgtggcac acggggaaca cgccggggca ggtgcgaacc ttatggcacg3540accccaggaa cattggctgg aaggactaca cggcctatag gtggcacctg actcacaggc3600ccaagactgg ctacatcaga gtcttagtgc atgaaggaaa acaggtcatg gcagactcag3660gacctatcta tgaccaaacc tacgctggcg ggcggctggg tctatttgtc ttctctcaag3720aaatggtcta tttctcagac ctcaagtacg aatgcagaga tatttaaaca agatttgctg3780
catttccggc aatgccctgt gcatgccatg gtccctagac acctcagttc attgtggtcc3840ttgtggcttc tctctctagc agcacctcct gtcccttgac cttaactctg atggttcttc3900acctcctgcc agcaacccca aacccaagtg ccttcagagg ataaatatca atggaactca3960gagatgaaca tctaacccac tagaggaaac cagtttggtg atatatgaga ctttatgtgg4020agtgaaaatt gggcatgcca ttacattgct ttttcttgtt tgtttaaaaa gaatgacgtt4080tacatataaa atgtaattac ttattgtatt tatgtgtata tggagttgaa gggaatactg4140tgcataagcc attatgataa attaagcatg aaaaatattg ctgaactact tttggtgctt4200aaagttgtca ctattcttga attagagttg ctctacaatg acacacaaat cccattaaat4260aaattataaa caagggtcaa ttcaaatttg aagtaatgtt ttagtaagga gagattagaa4320gacaacaggc atagcaaatg acataagcta ccgattaact aatcggaaca tgtaaaacag4380ttacaaaaat aaacgaactc tcctcttgtc ctacaatgaa agccctcatg tgcagtagag4440atgcagtttc atcaaagaac aaacatcctt gcaaatgggt gtgacgcggt tccagatgtg4500gatttggcaa aacctcattt aagtaaaagg ttagcagagc aaagtgcggt gctttagctg4560ctgcttgtgc cgctgtggcg tcggggaggc tcctgcctga gcttccttcc ccagctttgc4620tgcctgagag gaaccagagc agacgcacag gccggaaaag gcgcatctaa cgcgtatcta4680ggctttggta actgcggaca agttgctttt acctgatttg atgatacatt tcattaaggt4740tccagttata aatattttgt taatatttat taagtgacta tagaatgcaa ctccatttac4800cagtaactta ttttaaatat gcctagtaac acatatgtag tataatttct agaaacaaac4860atctaataag tatataatcc tgtgaaaata tgaggcttga taatattagg ttgtcacgat4920gaagcatgct agaagctgta acagaataca tagagaataa tgaggagttt atgatggaac4980cttaaatata taatgttgcc agcgatttta gttcaatatt tgttactgtt atctatctgc5040tgtatatgga attcttttaa ttcaaacgct gaaaagaatc agcatttagt cttgccaggc5100acacccaata atcagtcatg tgtaatatgc acaagtttgt ttttgttttt gttttttttg5160ttggttggtt tgtttttttg ctttaagttg catgatcttt ctgcaggaaa tagtcactca5220
tcccactcca cataaggggt ttagtaagag aagtctgtct gtctgatgat ggataggggg5280caaatctttt tcccctttct gttaatagtc atcacatttc tatgccaaac aggaacaatc5340cataacttta gtcttaatgt acacattgca ttttgataaa attaattttg ttgtttcctt5400tgaggttgat cgttgtgttg ttgttttgct gcacttttta cttttttgcg tgtggagctg5460tattcccgag accaacgaag cgttgggata cttcattaaa tgtagcgact gtcaacagcg5520tgcaggtttt ctgtttctgt gttgtggggt caaccgtaca atggtgtggg agtgacgatg5580atgtgaatat ttagaatgta ccatattttt tgtaaattat ttatgttttt ctaaacaaat5640ttatcgtata ggttgatgaa acgtcatgtg ttttgccaaa gactgtaaat atttatttat5700gtgttcacat ggtcaaaatt tcaccactga aaccctgcac ttagctagaa cctcattttt5760aaagattaac aacaggaaat aaattgtaaa aaaggttttc tatacatgaa aaaaaaaaaa5820aaaaaa 5826<210> 12<211> 1172<212> PRT<213> Homo sapiens<220>
<221> ѪС°å·´Ó¦µ°°×2¶àëÄÐòÁÐ<222> (1)..(1172)<400> 12Met Val Trp Arg Leu Val Leu Leu Ala Leu Trp Val Trp Pro Ser Thr1 5 10 15
Gln Ala Gly His Gln Asp Lys Asp Thr Thr Phe Asp Leu Phe Ser Ile20 25 30Ser Asn Ile Asn Arg Lys Thr Ile Gly Ala Lys Gln Phe Arg Gly Pro35 40 45Asp Pro Gly Val Pro Ala Tyr Arg Phe Val Arg Phe Asp Tyr Ile Pro50 55 60Pro Val Asn Ala Asp Asp Leu Ser Lys Ile Thr Lys Ile Met Arg Gln65 70 75 80Lys Glu Gly Phe Phe Leu Thr Ala Gln Leu Lys Gln Asp Gly Lys Ser85 90 95Arg Gly Thr Leu Leu Ala Leu Glu Gly Pro Gly Leu Ser Gln Arg Gln100 105 110Phe Glu Ile Val Ser Asn Gly Pro Ala Asp Thr Leu Asp Leu Thr Tyr115 120 125Trp Ile Asp Gly Thr Arg His Val Val Ser Leu Glu Asp Val Gly Leu130 135 140Ala Asp Ser Gln Trp Lys Asn Val Thr Val Gln Val Ala Gly Glu Thr145 150 155 160Tyr Ser Leu His Val Gly Cys Asp Leu Ile Asp Ser Phe Ala Leu Asp165 170 175Glu Pro Phe Tyr Glu His Leu Gln Ala Glu Lys Ser Arg Met Tyr Val180 185 190Ala Lys Gly Ser Ala Arg Glu Ser His Phe Arg Gly Leu Leu Gln Asn195 200 205
Val His Leu Val Phe Glu Asn Ser Val Glu Asp Ile Leu Ser Lys Lys210 215 220Gly Cys Gln Gln Gly Gln Gly Ala Glu Ile Asn Ala Ile Ser Glu Asn225 230 235 240Thr Glu Thr Leu Arg Leu Gly Pro His Val Thr Thr Glu Tyr Val Gly245 250 255Pro Ser Ser Glu Arg Arg Pro Glu Val Cys Glu Arg Ser Cys Glu Glu260 265 270Leu Gly Asn Met Val Gln Glu Leu Ser Gly Leu His Val Leu Val Asn275 280 285Gln Leu Ser Glu Asn Leu Lys Arg Val Ser Asn Asp Asn Gln Phe Leu290 295 300Trp Glu Leu Ile Gly Gly Pro Pro Lys Thr Arg Asn Met Ser Ala Cys305 310 315 320Trp Gln Asp Gly Arg Phe Phe Ala Glu Asn Glu Thr Trp Val Val Asp325 330 335Ser Cys Thr Thr Cys Thr Cys Lys Lys Phe Lys Thr Ile Cys His Gln340 345 350Ile Thr Cys Pro Pro Ala Thr Cys Ala Ser Pro Ser Phe Val Glu Gly355 360 365Glu Cys Cys Pro Ser Cys Leu His Ser Val Asp Gly Glu Glu Gly Trp370 375 380Ser Pro Trp Ala Glu Trp Thr Gln Cys Ser Val Thr Cys Gly Ser Gly385390 395 400
Thr Gln Gln Arg Gly Arg Ser Cys Asp Val Thr Ser Asn Thr Cys Leu405 410 415Gly Pro Ser Ile Gln Thr Arg Ala Cys Ser Leu Ser Lys Cys Asp Thr420 425 430Arg Ile Arg Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser435 440 445Cys Ser Val Thr Cys Gly Val Gly Asn Ile Thr Arg Ile Arg Leu Cys450 455 460Asn Ser Pro Val Pro Gln Met Gly Gly Lys Asn Cys Lys Gly Ser Gly465 470 475 480Arg Glu Thr Lys Ala Cys Gln Gly Ala Pro Cys Pro Ile Asp Gly Arg485 490 495Trp Ser Pro Trp Ser Pro Trp Ser Ala Cys Thr Val Thr Cys Ala Gly500 505 510Gly Ile Arg Glu Arg Thr Arg Val Cys Asn Ser Pro Glu Pro Gln Tyr515 520 525Gly Gly Lys Ala Cys Val Gly Asp Val Gln Glu Arg Gln Met Cys Asn530 535 540Lys Arg Ser Cys Pro Val Asp Gly Cys Leu Ser Asn Pro Cys Phe Pro545 550 555 560Gly Ala Gln Cys Ser Ser Phe Pro Asp Gly Ser Trp Ser Cys Gly Ser565 570 575Cys Pro Val Gly Phe Leu Gly Asn Gly Thr His Cys Glu Asp Leu Asp580 585 590
Glu Cys Ala Leu Val Pro Asp Ile Cys Phe Ser Thr Ser Lys Val Pro595 600 605Arg Cys Val Asn Thr Gln Pro Gly Phe His Cys Leu Pro Cys Pro Pro610 615 620Arg Tyr Arg Gly Asn Gln Pro Val Gly Val Gly Leu Glu Ala Ala Lys625 630 635 640Thr Glu Lys Gln Val Cys Glu Pro Glu Asn Pro Cys Lys Asp Lys Thr645 650 655His Asn Cys His Lys His Ala Glu Cys Ile Tyr Leu Gly His Phe Ser660 665 670Asp Pro Met Tyr Lys Cys Glu Cys Gln Thr Gly Tyr Ala Gly Asp Gly675 680 685Leu Ile Cys Gly Glu Asp Ser Asp Leu Asp Gly Trp Pro Asn Leu Asn690 695 700Leu Val Cys Ala Thr Asn Ala Thr Tyr His Cys Ile Lys Asp Asn Cys705 710 715 720Pro His Leu Pro Asn Ser Gly Gln Glu Asp Phe Asp Lys Asp Gly Ile725 730 735Gly Asp Ala Cys Asp Asp Asp Asp Asp Asn Asp Gly Val Thr Asp Glu740 745 750Lys Asp Asn Cys Gln Leu Leu Phe Asn Pro Arg Gln Ala Asp Tyr Asp755 760 765Lys Asp Glu Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Val His Asn770 775 780
Pro Ala Gln Ile Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ser785 790 795 800Val Asp Ile Asp Gly Asp Asp Val Phe Asn Glu Arg Asp Asn Cys Pro805 810 815Tyr Val Tyr Asn Thr Asp Gln Arg Asp Thr Asp Gly Asp Gly Val Gly820 825 830Asp His Cys Asp Asn Cys Pro Leu Val His Asn Pro Asp Gln Thr Asp835 840 845Val Asp Asn Asp Leu Val Gly Asp Gln Cys Asp Asn Asn Glu Asp Ile850 855 860Asp Asp Asp Gly His Gln Asn Asn Gln Asp Asn Cys Pro Tyr Ile Ser865 870 875 880Asn Ala Asn Gln Ala Asp His Asp Arg Asp Gly Gln Gly Asp Ala Cys885 890 895Asp Pro Asp Asp Asp Asn Asp Gly Val Pro Asp Asp Arg Asp Asn Cys900 905 910Arg Leu Val Phe Asn Pro Asp Gln Glu Asp Leu Asp Gly Asp Gly Arg915 920 925Gly Asp Ile Cys Lys Asp Asp Phe Asp Asn Asp Asn Ile Pro Asp Ile930 935 940Asp Asp Val Cys Pro Glu Asn Asn Ala Ile Ser Glu Thr Asp Phe Arg945 950 955 960Asn Phe Gln Met Val Pro Leu Asp Pro Lys Gly Thr Thr Gln Ile Asp965 970 975
Pro Asn Trp Val Ile Arg His Gln Gly Lys Glu Leu Val Gln Thr Ala980 985 990Asn Ser Asp Pro Gly Ile Ala Val Gly Phe Asp Glu Phe Gly Ser Val995 1000 1005Asp Phe Ser Gly Thr Phe Tyr Val Asn Thr Asp Arg Asp Asp Asp10101015 1020Tyr Ala Gly Phe Val Phe Gly Tyr Gln Ser Ser Ser Arg Phe Tyr10251030 1035Val Val Met Trp Lys Gln Val Thr Gln Thr Tyr Trp Glu Asp Gln10401045 1050Pro Thr Arg Ala Tyr Gly Tyr Ser Gly Val Ser Leu Lys Val Val10551060 1065Asn Ser Thr Thr Gly Thr Gly Glu His Leu Arg Asn Ala Leu Trp10701075 1080His Thr Gly Asn Thr Pro Gly Gln Val Arg Thr Leu Trp His Asp10851090 1095Pro Arg Asn Ile Gly Trp Lys Asp Tyr Thr Ala Tyr Arg Trp His11001105 1110Leu Thr His Arg Pro Lys Thr Gly Tyr Ile Arg Val Leu Val His11151120 1125Glu Gly Lys Gln Val Met Ala Asp Ser Gly Pro Ile Tyr Asp Gln11301135 1140Thr Tyr Ala Gly Gly Arg Leu Gly Leu Phe Val Phe Ser Gln Glu11451150 1155
Met Val Tyr Phe Ser Asp Leu Lys Tyr Glu Cys Arg Asp Ile1160 1165 1170<210> 13<211> 2313<212> DNA<213> Homo sapiens<220>
<221> fibulin-1 C mRNA<222> (1)..(2313)<400> 13ctcctcccgg gcgggataat tgaacggcgc ggccctggcc cagcgttggc tgccgaggct 60cggccggagc gtggagcccg cgccgctgcc ccaggaccgc gcccgcgcct ttgtccgccg120ccgcccaccg cccgtcgccc gccgcccatg gagcgcgccg cgccgtcgcg ccgggtcccg180cttccgctgc tgctgctcgg cggccttgcg ctgctggcgg ccggagtgga cgcggatgtc240ctcctggagg cctgctgtgc ggacggacac cggatggcca ctcatcagaa ggactgctcg300ctgccatatg ctacggaatc caaagaatgc aggatggtgc aggagcagtg ctgccacagc360cagctggagg agctgcactg tgccacgggc atcagcctgg ccaacgagca ggaccgctgt420gccacgcccc acggtgacaa cgccagcctg gaggccacat ttgtgaagag gtgctgccat480tgctgtctgc tggggagggc ggcccaggcc cagggccaga gctgcgagta cagcctcatg540gttggctacc agtgtggaca ggtcttccgg gcatgctgtg tcaagagcca ggagaccgga600gatttggatg tcgggggcct ccaagaaacg gataagatca ttgaggttga ggaggaacaa660gaggacccat atctgaatga ccgctgccga ggaggcgggc cctgcaagca gcagtgccga720gacacgggtg acgaggtggt ctgctcctgc ttcgtgggct accagctgct gtctgatggt780
gtctcctgtg aagatgtcaa tgaatgcatc acgggcagcc acagctgccg gcttggagaa 840tcctgcatca acacagtggg ctctttccgc tgccagcggg acagcagctg cgggactggc 900tatgagctca cagaggacaa tagctgcaaa gatattgacg agtgtgagag tggtattcat 960aactgcctcc ccgattttat ctgtcagaat actctgggat ccttccgctg ccgacccaag1020ctacagtgca agagtggctt tatacaagat gctctaggca actgtattga tatcaatgag1080tgtttgagta tcagtgcccc gtgccctatc gggcatacat gcatcaacac agagggctcc1140tacacgtgcc agaagaacgt gcccaactgt ggccgtggct accatctcaa cgaggaggga1200acgcgctgtg ttgatgtgga cgagtgcgcg ccacctgctg agccctgtgg gaagggacat1260cgctgcgtga actctcccgg cagtttccgc tgcgaatgca agacgggtta ctattttgac1320ggcatcagca ggatgtgtgt cgatgtcaac gagtgccagc gctaccccgg gcgcctgtgt1380ggccacaagt gcgagaacac gctgggctcc tacctctgca gctgttccgt gggcttccgg1440ctctctgtgg atggcaggtc atgtgaagac atcaatgagt gcagcagcag cccctgtagc1500caggagtgtg ccaacgtcta cggctcctac cagtgttact gccggcgagg ctaccagctc1560agcgatgtgg atggagtcac ctgtgaagac atcgacgagt gcgccctgcc caccgggggc1620cacatctgct cctaccgctg catcaacatc cctggaagct tccagtgcag ctgcccctcg1680tctggctaca ggctggcccc caatggccgc aactgccaag acattgatga gtgtgtgact1740ggcatccaca actgctccat caacgagacc tgcttcaaca tccagggcgg cttccgctgc1800ctggccttcg agtgccctga gaactaccgc cgctccgcag ccacccgctg tgagcgcttg1860ccttgccatg agaatcggga gtgctccaag ctgcctctga gaataaccta ctaccacctc1920tctttcccca ccaacatcca agcgcccgcg gtggttttcc gcatgggccc ctccagtgct1980gtccccgggg acagcatgca gctggccatc accggcggca atgaggaggg ctttttcacc2040acccggaagg tgagccccca cagtggggtg gtggccctca ccaagcctgt ccccgagccc2100agggacttgc tcctgaccgt caagatggat ctctctcgcc acggcaccgt cagctccttt2160gtggccaagc ttttcatctt tgtgtctgca gagctctgag cactcgcttc gcgtcgcggg2220
gtctccctcc tgttgctttc ctaaccctgc cctccggggc gttaataaag tcttagcaag2280cgtcccacac agtgaaaaaa aaaaaaaaaa aaa 2313<210> 14<211> 683<212> PRT<213> Homo sapiens<220>
<221> fibulin 1 C¶àëÄÐòÁÐ<222> (1)..(683)<400> 14Met Glu Arg Ala Ala Pro Ser Arg Arg Val Pro Leu Pro Leu Leu Leu1 5 10 15Leu Gly Gly Leu Ala Leu Leu Ala Ala Gly Val Asp Ala Asp Val Leu20 25 30Leu Glu Ala Cys Cys Ala Asp Gly His Arg Met Ala Thr His Gln Lys35 40 45Asp Cys Ser Leu Pro Tyr Ala Thr Glu Ser Lys Glu Cys Arg Met Val50 55 60Gln Glu Gln Cys Cys His Ser Gln Leu Glu Glu Leu His Cys Ala Thr65 70 75 80Gly Ile Ser Leu Ala Asn Glu Gln Asp Arg Cys Ala Thr Pro His Gly85 90 95
Asp Asn Ala Ser Leu Glu Ala Thr Phe Val Lys Arg Cys Cys His Cys100 105 110Cys Leu Leu Gly Arg Ala Ala Gln Ala Gln Gly Gln Ser Cys Glu Tyr115 120 125Ser Leu Met Val Gly Tyr Gln Cys Gly Gln Val Phe Arg Ala Cys Cys130 135 140Val Lys Ser Gln Glu Thr Gly Asp Leu Asp Val Gly Gly Leu Gln Glu145 150 155 160Thr Asp Lys Ile Ile Glu Val Glu Glu Glu Gln Glu Asp Pro Tyr Leu165 170 175Asn Asp Arg Cys Arg Gly Gly Gly Pro Cys Lys Gln Gln Cys Arg Asp180 185 190Thr Gly Asp Glu Val Val Cys Ser Cys Phe Val Gly Tyr Gln Leu Leu195 200 205Ser Asp Gly Val Ser Cys Glu Asp Val Asn Glu Cys Ile Thr Gly Ser210 215 220His Ser Cys Arg Leu Gly Glu Ser Cys Ile Asn Thr Val Gly Ser Phe225 230 235 240Arg Cys Gln Arg Asp Ser Ser Cys Gly Thr Gly Tyr Glu Leu Thr Glu245 250 255Asp Asn Ser Cys Lys Asp Ile Asp Glu Cys Glu Ser Gly Ile His Asn260 265 270Cys Leu Pro Asp Phe Ile Cys Gln Asn Thr Leu Gly Ser Phe Arg Cys275 280 285
Arg Pro Lys Leu Gln Cys Lys Ser Gly Phe Ile Gln Asp Ala Leu Gly290 295 300Asn Cys Ile Asp Ile Asn Glu Cys Leu Ser Ile Ser Ala Pro Cys Pro305 310 315 320Ile Gly His Thr Cys Ile Asn Thr Glu Gly Ser Tyr Thr Cys Gln Lys325 330 335Asn Val Pro Asn Cys Gly Arg Gly Tyr His Leu Asn Glu Glu Gly Thr340 345 350Arg Cys Val Asp Val Asp Glu Cys Ala Pro Pro Ala Glu Pro Cys Gly355 360 365Lys Gly His Arg Cys Val Asn Ser Pro Gly Ser Phe Arg Cys Glu Cys370 375 380Lys Thr Gly Tyr Tyr Phe Asp Gly Ile Ser Arg Met Cys Val Asp Val385 390 395 400Asn Glu Cys Gln Arg Tyr Pro Gly Arg Leu Cys Gly His Lys Cys Glu405 410 415Asn Thr Leu Gly Ser Tyr Leu Cys Ser Cys Ser Val Gly Phe Arg Leu420 425 430Ser Val Asp Gly Arg Ser Cys Glu Asp Ile Asn Glu Cys Ser Ser Ser435 440 445Pro Cys Ser Gln Glu Cys Ala Asn Val Tyr Gly Ser Tyr Gln Cys Tyr450 455 460Cys Arg Arg Gly Tyr Gln Leu Ser Asp Val Asp Gly Val Thr Cys Glu465 470 475 480
Asp Ile Asp Glu Cys Ala Leu Pro Thr Gly Gly His Ile Cys Ser Tyr485 490 495Arg Cys Ile Asn Ile Pro Gly Ser Phe Gln Cys Ser Cys Pro Ser Ser500 505 510Gly Tyr Arg Leu Ala Pro Asn Gly Arg Asn Cys Gln Asp Ile Asp Glu515 520 525Cys Val Thr Gly Ile His Asn Cys Ser Ile Asn Glu Thr Cys Phe Asn530 535 540Ile Gln Gly Gly Phe Arg Cys Leu Ala Phe Glu Cys Pro Glu Asn Tyr545 550 555 560Arg Arg Ser Ala Ala Thr Arg Cys Glu Arg Leu Pro Cys His Glu Asn565 570 575Arg Glu Cys Ser Lys Leu Pro Leu Arg Ile Thr Tyr Tyr His Leu Ser580 585 590Phe Pro Thr Asn Ile Gln Ala Pro Ala Val Val Phe Arg Met Gly Pro595 600 605Ser Ser Ala Val Pro Gly Asp Ser Met Gln Leu Ala Ile Thr Gly Gly610 615 620Asn Glu Glu Gly Phe Phe Thr Thr Arg Lys Val Ser Pro His Ser Gly625 630 635 640Val Val Ala Leu Thr Lys Pro Val Pro Glu Pro Arg Asp Leu Leu Leu645 650 655Thr Val Lys Met Asp Leu Ser Arg His Gly Thr Val Ser Ser Phe Val660 665 670
Ala Lys Leu Phe Ile Phe Val Ser Ala Glu Leu675 680<210> 15<211> 2485<212> DNA<213> Homo sapiens<220>
<221> ĤÁªµ°°×A11 mRNA<222> (1)..(2485)<400> 15gcactgcctc tggcacctgg ggcagccgcg cccgcggagt tttccgcccg gcgctgacgg 60ctgctgcgcc cgcggctccc cagtgccccg agtgccccgc gggccccgcg agcgggagtg120ggacccagcc ctaggcagaa cccaggcgcc gcgcccggga cgcccgcgga gagagccact180cccgcccacg tcccatttcg cccctcgcgt ccggagtccc cgtggccaga tctaaccatg240agctaccctg gctatccccc gcccccaggt ggctacccac cagctgcacc aggtggtggt300ccctggggag gtgctgccta ccctcctccg cccagcatgc cccccatcgg gctggataac360gtggccacct atgcggggca gttcaaccag gactatctct cgggaatggc ggccaacatg420tctgggacat ttggaggagc caacatgccc aacctgtacc ctggggcccc tggggctggc480tacccaccag tgccccctgg cggctttggg cagcccccct ctgcccagca gcctgttcct540ccctatggga tgtatccacc cccaggagga aacccaccct ccaggatgcc ctcatatccg600ccatacccag gggcccctgt gccgggccag cccatgccac cccccggaca gcagccccca660ggggcctacc ctgggcagcc accagtgacc taccctggtc agcctccagt gccactccct720
gggcagcagc agccagtgcc gagctaccca ggatacccgg ggtctgggac tgtcaccccc 780gctgtgcccc caacccagtt tggaagccga ggcaccatca ctgatgctcc cggctttgac 840cccctgcgag atgccgaggt cctgcggaag gccatgaaag gcttcgggac ggatgagcag 900gccatcattg actgcctggg gagtcgctcc aacaagcagc ggcagcagat cctactttcc 960ttcaagacgg cttacggcaa ggatttgatc aaagatctga aatctgaact gtcaggaaac1020tttgagaaga caatcttggc tctgatgaag accccagtcc tctttgacat ttatgagata1080aaggaagcca tcaagggggt tggcactgat gaagcctgcc tgattgagat cctcgcttcc1140cgcagcaatg agcacatccg agaattaaac agagcctaca aagcagaatt caaaaagacc1200ctggaagagg ccattcgaag cgacacatca gggcacttcc agcggctcct catctctctc1260tctcagggaa accgtgatga aagcacaaac gtggacatgt cactcgccca gagagatgcc1320caggagctgt atgcggccgg ggagaaccgc ctgggaacag acgagtccaa gttcaatgcg1380gttctgtgct cccggagccg ggcccacctg gtagcagttt tcaatgagta ccagagaatg1440acaggccggg acattgagaa gagcatctgc cgggagatgt ccggggacct ggaggagggc1500atgctggccg tggtgaaatg tctcaagaat accccagcct tctttgcgga gaggctcaac1560aaggccatga ggggggcagg aacaaaggac cggaccctga ttcgcatcat ggtgtctcgc1620agcgagaccg acctcctgga catcagatca gagtataagc ggatgtacgg caagtcgctg1680taccacgaca tctcgggaga tacttcaggg gattaccgga agattctgct gaagatctgt1740ggtggcaatg actgaacagt gactggtggc tcacttctgc ccacctgccg gcaacaccag1800tgccaggaaa aggccaaaag aatgtctgtt tctaacaaat ccacaaatag ccccgagatt1860caccgtccta gagcttaggc ctgtcttcca cccctcctga cccgtatagt gtgccacagg1920acctgggtcg gtctagaact ctctcaggat gccttttcta ccccatccct cacagcctct1980tgctgctaaa atagatgttt catttttctg actcatgcaa tcattcccct ttgcctgtgg2040ctaagacttg gcttcatttc gtcatgtaat tgtatatttt tatttggagg catattttct2100tttcttacag tcattgccag acagaggcat acaagtctgt ttgctgcata cacatttctg2160
gtgagggcga ctgggtgggt gaagcaccgt gtcctcgctg aggagagaaa gggaggcgtg2220cctgagaggg tagcctgtgc atctggtgag tgtgtcacga gctttgttac tgccaaactc2280actccttttt agaaaaaaca aaaaaaaagg gccagaaagt cattccttcc atcttccttg2340cagaaaccac gagaacaaag ccagttccct gtcagtgaca gggcttcttg taatttgtgg2400tatgtgcctt aaacctgaat gtctgtagcc aaaacttgtt tccacattaa gagtcagcca2460gctctggaat ggtctggaaa tgtca 2485<210> 16<211> 505<212> PRT<213> Homo sapiens<220>
<221> ĤÁªµ°°×A11¶àëÄÐòÁÐ<222> (1)..(505)<400> 16Met Ser Tyr Pro Gly Tyr Pro Pro Pro Pro Gly Gly Tyr Pro Pro Ala1 5 10 15Ala Pro Gly Gly Gly Pro Trp Gly Gly Ala Ala Tyr Pro Pro Pro Pro20 25 30Ser Met Pro Pro Ile Gly Leu Asp Asn Val Ala Thr Tyr Ala Gly Gln35 40 45Phe Asn Gln Asp Tyr Leu Ser Gly Met Ala Ala Asn Met Ser Gly Thr50 55 60
Phe Gly Gly Ala Asn Met Pro Asn Leu Tyr Pro Gly Ala Pro Gly Ala65 70 75 80Gly Tyr Pro Pro Val Pro Pro Gly Gly Phe Gly Gln Pro Pro Ser Ala85 90 95Gln Gln Pro Val Pro Pro Tyr Gly Met Tyr Pro Pro Pro Gly Gly Asn100 105 110Pro Pro Ser Arg Met Pro Ser Tyr Pro Pro Tyr Pro Gly Ala Pro Val115 120 125Pro Gly Gln Pro Met Pro Pro Pro Gly Gln Gln Pro Pro Gly Ala Tyr130 135 140Pro Gly Gln Pro Pro Val Thr Tyr Pro Gly Gln Pro Pro Val Pro Leu145 150 155 160Pro Gly Gln Gln Gln Pro Val Pro Ser Tyr Pro Gly Tyr Pro Gly Ser165 170 175Gly Thr Val Thr Pro Ala Val Pro Pro Thr Gln Phe Gly Ser Arg Gly180 185 190Thr Ile Thr Asp Ala Pro Gly Phe Asp Pro Leu Arg Asp Ala Glu Val195 200 205Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Ile210 215 220Asp Cys Leu Gly Ser Arg Ser Asn Lys Gln Arg Gln Gln Ile Leu Leu225 230 235 240Ser Phe Lys Thr Ala Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser245 250 255
Glu Leu Ser Gly Asn Phe Glu Lys Thr Ile Leu Ala Leu Met Lys Thr260 265 270Pro Val Leu Phe Asp Ile Tyr Glu Ile Lys Glu Ala Ile Lys Gly Val275 280 285Gly Thr Asp Glu Ala Cys Leu Ile Glu Ile Leu Ala Ser Arg Ser Asn290 295 300Glu His Ile Arg Glu Leu Asn Arg Ala Tyr Lys Ala Glu Phe Lys Lys305 310 315 320Thr Leu Glu Glu Ala Ile Arg Ser Asp Thr Ser Gly His Phe Gln Arg325 330 335Leu Leu Ile Ser Leu Ser Gln Gly Asn Arg Asp Glu Ser Thr Asn Val340 345 350Asp Met Ser Leu Ala Gln Arg Asp Ala Gln Glu Leu Tyr Ala Ala Gly355 360 365Glu Asn Arg Leu Gly Thr Asp Glu Ser Lys Phe Asn Ala Val Leu Cys370 375 380Ser Arg Ser Arg Ala His Leu Val Ala Val Phe Asn Glu Tyr Gln Arg385 390 395 400Met Thr Gly Arg Asp Ile Glu Lys Ser Ile Cys Arg Glu Met Ser Gly405 410 415Asp Leu Glu Glu Gly Met Leu Ala Val Val Lys Cys Leu Lys Asn Thr420 425 430Pro Ala Phe Phe Ala Glu Arg Leu Asn Lys Ala Met Arg Gly Ala Gly435 440 445
Thr Lys Asp Arg Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Thr450 455 460Asp Leu Leu Asp Ile Arg Ser Glu Tyr Lys Arg Met Tyr Gly Lys Ser465 470 475 480Leu Tyr His Asp Ile Ser Gly Asp Thr Ser Gly Asp Tyr Arg Lys Ile485 490 495Leu Leu Lys Ile Cys Gly Gly Asn Asp500 505<210> 17<211> 3309<212> DNA<213> Homo sapiens<220>
<221> µ°°×S mRNA<222> (1)..(3309)<400> 17ctgcaggggg gggggggggg gggggggggg ggggggggcg cagcacggct cagaccgagg 60cgcacaggct cgcagctccg ggcgcctagc gcccggtccc cgccgcgacg cgccaccgtc120cctgccggcg cctccgcgcc ttcgaaatga gggtcctggg tgggcgctgc ggggcgccgc180tggcgtgtct cctcctagtg cttcccgtct cagaggcaaa ccttctgtca aagcaacagg240cttcacaagt cctggttagg aagcgtcgtg caaattcttt acttgaagaa accaaacagg300
gtaatcttga aagagaatgc atcgaagaac tgtgcaataa agaagaagcc agggaggtct360ttgaaaatga cccggaaacg gattattttt atccaaaata cttagtttgt cttcgctctt420ttcaaactgg gttattcact gctgcacgtc agtcaactaa tgcttatcct gacctaagaa480gctgtgtcaa tgccattcca gaccagtgta gtcctctgcc atgcaatgaa gatggatata540tgagctgcaa agatggaaaa gcttctttta cttgcacttg taaaccaggt tggcaaggag600aaaagtgtga atttgacata aatgaatgca aagatccctc aaatataaat ggaggttgca660gtcaaatttg tgataataca cctggaagtt accactgttc ctgtaaaaat ggttttgtta720tgctttcaaa taagaaagat tgtaaagatg tggatgaatg ctctttgaag ccaagcattt780gtggcacagc tgtgtgcaag aacatcccag gagattttga atgtgaatgc cccgaaggct840acagatataa tctcaaatca aagtcttgtg aagatataga tgaatgctct gagaacatgt900gtgctcagct ttgtgtcaat taccctggag gttacacttg ctattgtgat gggaagaaag960gattcaaact tgcccaagat cagaagagtt gtgaggttgt ttcagtgtgc cttcccttga 1020accttgacac aaagtatgaa ttactttact tggcggagca gtttgcaggg gttgttttat 1080atttaaaatt tcgtttgcca gaaatcagca gattttcagc agaatttgat ttccggacat 1140atgattcaga aggcgtgata ctgtacgcag aatctatcga tcactcagcg tggctcctga 1200ttgcacttcg tggtggaaag attgaagttc agcttaagaa tgaacataca tccaaaatca 1260caactggagg tgatgttatt aataatggtc tatggaatat ggtgtctgtg gaagaattag 1320aacatagtat tagcattaaa atagctaaag aagctgtgat ggatataaat aaacctggac 1380ccctttttaa gccggaaaat ggattgctgg aaaccaaagt atactttgca ggattccctc 1440ggaaagtgga aagtgaactc attaaaccga ttaaccctcg tctagatgga tgtatacgaa 1500gctggaattt gatgaagcaa ggagcttctg gaataaagga aattattcaa gaaaaacaaa 1560ataagcattg cctggttact gtggagaagg gctcctacta tcctggttct ggaattgctc 1620aatttcacat agattataat aatgtatcca gtgctgaggg ttggcatgta aatgtgacct 1680tgaatattcg tccatccacg ggcactggtg ttatgcttgc cttggtttct ggtaacaaca 1740
cagtgccctt tgctgtgtcc ttggtggact ccacctctga aaaatcacag gatattctgt1800tatctgttga aaatactgta atatatcgga tacaggccct aagtctatgt tccgatcaac1860aatctcatct ggaatttaga gtcaacagaa acaatctgga gttgtcgaca ccacttaaaa1920tagaaaccat ctcccatgaa gaccttcaaa gacaacttgc cgtcttggac aaagcaatga1980aagcaaaagt ggccacatac ctgggtggcc ttccagatgt tccattcagt gccacaccag2040tgaatgcctt ttataatggc tgcatggaag tgaatattaa tggtgtacag ttggatctgg2100atgaagccat ttctaaacat aatgatatta gagctcactc atgtccatca gtttggaaaa2160agacaaagaa ttcttaaggc atcttttctc tgcttataat accttttcct tgtgtgtaat2220tatacttatg tttcaataac agctgaaggg ttttatttac aatgtgcagt ctttgattat2280tttgtggtcc tttcctggga tttttaaaag gtcctttgtc aaggaaaaaa attctgttgt2340gatataaatc acagtaaaga aattcttact tctcttgcta tctaagaata gtgaaaaata2400acaattttaa atttgaattt ttttcctaca aatgacagtt tcaatttttg tttgtaaaac2460taaattttaa ttttatcatc atgaactagt gtctaaatac ctatgttttt ttcagaaagc2520aaggaagtaa actcaaacaa aagtgcgtgt aattaaatac tattaatcat aggcagatac2580tattttgttt atgtttttgt ttttttcctg atgaaggcag aagagatggt ggtctattaa2640atatgaattg aatggagggt cctaatgcct tatttcaaaa caattcctca gggggaccag2700ctttggcttc atctttctct tgtgtggctt cacatttaaa ccagtatctt tattgaatta2760gaaaacaagt gggacatatt ttcctgagag cagcacagga atcttcttct tggcagctgc2820agtctgtcag gatgagatat cagattaggt tggataggtg gggaaatctg aagtgggtac2880attttttaaa ttttgctgtg tgggtcacac aaggtctaca ttacaaaaga cagaattcag2940ggatggaaag gagaatgaac aaatgtggga gttcatagtt ttccttgaat ccaactttta3000attaccagag taagttgcca aaatgtgatt gttgaagtac aaaaggaact atgaaaacca3060gaacaaattt taacaaaagg acaaccacag agggatatag tgaatatcgt atcattgtaa3120tcaaagaagt aaggaggtaa gattgccacg tgcctgctgg tactgtgatg catttcaagt3180
ggcagtttta tcacgtttga atctaccatt catagccaga tgtgtatcag atgtttcact3240gacagttttt aacaataaat tcttttcact gtattttata tcacttataa taaatcggtg3300tataatttt3309<210> 18<211> 676<212> PRT<213> Homo sapiens<220>
<221> µ°°×S¶àëÄÐòÁÐ<222> (1)..(676)<400> 18Met Arg Val Leu Gly Gly Arg Cys Gly Ala Pro Leu Ala Cys Leu Leu1 5 10 15Leu Val Leu Pro Val Ser Glu Ala Asn Leu Leu Ser Lys Gln Gln Ala20 25 30Ser Gln Val Leu Val Arg Lys Arg Arg Ala Asn Ser Leu Leu Glu Glu35 40 45Thr Lys Gln Gly Asn Leu Glu Arg Glu Cys Ile Glu Glu Leu Cys Asn50 55 60Lys Glu Glu Ala Arg Glu Val Phe Glu Asn Asp Pro Glu Thr Asp Tyr65 70 75 80Phe Tyr Pro Lys Tyr Leu Val Cys Leu Arg Ser Phe Gln Thr Gly Leu
85 90 95Phe Thr Ala Ala Arg Gln Ser Thr Asn Ala Tyr Pro Asp Leu Arg Ser100 105 110Cys Val Asn Ala Ile Pro Asp Gln Cys Ser Pro Leu Pro Cys Asn Glu115 120 125Asp Gly Tyr Met Ser Cys Lys Asp Gly Lys Ala Ser Phe Thr Cys Thr130 135 140Cys Lys Pro Gly Trp Gln Gly Glu Lys Cys Glu Phe Asp Ile Asn Glu145 150 155 160Cys Lys Asp Pro Ser Asn Ile Asn Gly Gly Cys Ser Gln Ile Cys Asp165 170 175Asn Thr Pro Gly Ser Tyr His Cys Ser Cys Lys Asn Gly Phe Val Met180 185 190Leu Ser Asn Lys Lys Asp Cys Lys Asp Val Asp Glu Cys Ser Leu Lys195 200 205Pro Ser Ile Cys Gly Thr Ala Val Cys Lys Asn Ile Pro Gly Asp Phe210 215 220Glu Cys Glu Cys Pro Glu Gly Tyr Arg Tyr Asn Leu Lys Ser Lys Ser225 230 235 240Cys Glu Asp Ile Asp Glu Cys Ser Glu Asn Met Cys Ala Gln Leu Cys245 250 255Val Asn Tyr Pro Gly Gly Tyr Thr Cys Tyr Cys Asp Gly Lys Lys Gly260 265 270Phe Lys Leu Ala Gln Asp Gln Lys Ser Cys Glu Val Val Ser Val Cys
275 280 285Leu Pro Leu Asn Leu Asp Thr Lys Tyr Glu Leu Leu Tyr Leu Ala Glu290 295 300Gln Phe Ala Gly Val Val Leu Tyr Leu Lys Phe Arg Leu Pro Glu Ile305 310 315 320Ser Arg Phe Ser Ala Glu Phe Asp Phe Arg Thr Tyr Asp Ser Glu Gly325 330 335Val Ile Leu Tyr Ala Glu Ser Ile Asp His Ser Ala Trp Leu Leu Ile340 345 350Ala Leu Arg Gly Gly Lys Ile Glu Val Gln Leu Lys Asn Glu His Thr355 360 365Ser Lys Ile Thr Thr Gly Gly Asp Val Ile Asn Asn Gly Leu Trp Asn370 375 380Met Val Ser Val Glu Glu Leu Glu His Ser Ile Ser Ile Lys Ile Ala385 390 395 400Lys Glu Ala Val Met Asp Ile Asn Lys Pro Gly Pro Leu Phe Lys Pro405 410 415Glu Asn Gly Leu Leu Glu Thr Lys Val Tyr Phe Ala Gly Phe Pro Arg420 425 430Lys Val Glu Ser Glu Leu Ile Lys Pro Ile Asn Pro Arg Leu Asp Gly435 440 445Cys Ile Arg Ser Trp Asn Leu Met Lys Gln Gly Ala Ser Gly Ile Lys450 455 460Glu Ile Ile Gln Glu Lys Gln Asn Lys His Cys Leu Val Thr Val Glu
465 470 475 480Lys Gly Ser Tyr Tyr Pro Gly Ser Gly Ile Ala Gln Phe His Ile Asp485 490 495Tyr Asn Asn Val Ser Ser Ala Glu Gly Trp His Val Asn Val Thr Leu500 505 510Asn Ile Arg Pro Ser Thr Gly Thr Gly Val Met Leu Ala Leu Val Ser515 520 525Gly Asn Asn Thr Val Pro Phe Ala Val Ser Leu Val Asp Ser Thr Ser530 535 540Glu Lys Ser Gln Asp Ile Leu Leu Ser Val Glu Asn Thr Val Ile Tyr545 550 555 560Arg Ile Gln Ala Leu Ser Leu Cys Ser Asp Gln Gln Ser His Leu Glu565 570 575Phe Arg Val Asn Arg Asn Asn Leu Glu Leu Ser Thr Pro Leu Lys Ile580 585 590Glu Thr Ile Ser His Glu Asp Leu Gln Arg Gln Leu Ala Val Leu Asp595 600 605Lys Ala Met Lys Ala Lys Val Ala Thr Tyr Leu Gly Gly Leu Pro Asp610 615 620Val Pro Phe Ser Ala Thr Pro Val Asn Ala Phe Tyr Asn Gly Cys Met625 630 635 640Glu Val Asn Ile Asn Gly Val Gln Leu Asp Leu Asp Glu Ala Ile Ser645 650 655Lys His Asn Asp Ile Arg Ala His Ser Cys Pro Ser Val Trp Lys Lys
660 665 670Thr Lys Asn Ser675<210> 19<211> 3926<212> DNA<213> Homo sapiens<220>
<221> HÒò×Ó1(²¹Ìå)mRNA<222> (1)..(3926)<400> 19aattcttgga agaggagaac tggacgttgt gaacagagtt agctggtaaa tgtcctctta 60aaagatccaa aaaatgagac ttctagcaaa gattatttgc cttatgttat gggctatttg120tgtagcagaa gattgcaatg aacttcctcc aagaagaaat acagaaattc tgacaggttc180ctggtctgac caaacatatc cagaaggcac ccaggctatc tataaatgcc gccctggata240tagatctctt ggaaatgtaa taatggtatg caggaaggga gaatgggttg ctcttaatcc300attaaggaaa tgtcagaaaa ggccctgtgg acatcctgga gatactcctt ttggtacttt360tacccttaca ggaggaaatg tgtttgaata tggtgtaaaa gctgtgtata catgtaatga420ggggtatcaa ttgctaggtg agattaatta ccgtgaatgt gacacagatg gatggaccaa480tgatattcct atatgtgaag ttgtgaagtg tttaccagtg acagcaccag agaatggaaa540aattgtcagt agtgcaatgg aaccagatcg ggaataccat tttggacaag cagtacggtt600tgtatgtaac tcaggctaca agattgaagg agatgaagaa atgcattgtt cagacgatgg660
tttttggagt aaagagaaac caaagtgtgt ggaaatttca tgcaaatccc cagatgttat720aaatggatct cctatatctc agaagattat ttataaggag aatgaacgat ttcaatataa780atgtaacatg ggttatgaat acagtgaaag aggagatgct gtatgcactg aatctggatg840gcgtccgttg ccttcatgtg aagaaaaatc atgtgataat ccttatattc caaatggtga900ctactcacct ttaaggatta aacacagaac tggagatgaa atcacgtacc agtgtagaaa960tggtttttat cctgcaaccc ggggaaatac agccaaatgc acaagtactg gctggatacc 1020tgctccgaga tgtaccttga aaccttgtga ttatccagac attaaacatg gaggtctata 1080tcatgagaat atgcgtagac catactttcc agtagctgta ggaaaatatt actcctatta 1140ctgtgatgaa cattttgaga ctccgtcagg aagttactgg gatcacattc attgcacaca 1200agatggatgg tcgccagcag taccatgcct cagaaaatgt tattttcctt atttggaaaa 1260tggatataat caaaatcatg gaagaaagtt tgtacagggt aaatctatag acgttgcctg 1320ccatcctggc tacgctcttc caaaagcgca gaccacagtt acatgtatgg agaatggctg 1380gtctcctact cccagatgca tccgtgtcaa aacatgttcc aaatcaagta tagatattga 1440gaatgggttt atttctgaat ctcagtatac atatgcctta aaagaaaaag cgaaatatca 1500atgcaaacta ggatatgtaa cagcagatgg tgaaacatca ggatcaatta gatgtgggaa 1560agatggatgg tcagctcaac ccacgtgcat taaatcttgt gatatcccag tatttatgaa 1620tgccagaact aaaaatgact tcacatggtt taagctgaat gacacattgg actatgaatg 1680ccatgatggt tatgaaagca atactggaag caccactggt tccatagtgt gtggttacaa 1740tggttggtct gatttaccca tatgttatga aagagaatgc gaacttccta aaatagatgt 1800acacttagtt cctgatcgca agaaagacca gtataaagtt ggagaggtgt tgaaattctc 1860ctgcaaacca ggatttacaa tagttggacc taattccgtt cagtgctacc actttggatt 1920gtctcctgac ctcccaatat gtaaagagca agtacaatca tgtggtccac ctcctgaact 1980cctcaatggg aatgttaagg aaaaaacgaa agaagaatat ggacacagtg aagtggtgga 2040atattattgc aatcctagat ttctaatgaa gggacctaat aaaattcaat gtgttgatgg 2100
agagtggaca actttaccag tgtgtattgt ggaggagagt acctgtggag atatacctga2160acttgaacat ggctgggccc agctttcttc ccctccttat tactatggag attcagtgga2220attcaattgc tcagaatcat ttacaatgat tggacacaga tcaattacgt gtattcatgg2280agtatggacc caacttcccc agtgtgtggc aatagataaa cttaagaagt gcaaatcatc2340aaatttaatt atacttgagg aacatttaaa aaacaagaag gaattcgatc ataattctaa2400cataaggtac agatgtagag gaaaagaagg atggatacac acagtctgca taaatggaag2460atgggatcca gaagtgaact gctcaatggc acaaatacaa ttatgcccac ctccacctca2520gattcccaat tctcacaata tgacaaccac actgaattat cgggatggag aaaaagtatc2580tgttctttgc caagaaaatt atctaattca ggaaggagaa gaaattacat gcaaagatgg2640aagatggcag tcaataccac tctgtgttga aaaaattcca tgttcacaac cacctcagat2700agaacacgga accattaatt catccaggtc ttcacaagaa agttatgcac atgggactaa2760attgagttat acttgtgagg gtggtttcag gatatctgaa gaaaatgaaa caacatgcta2820catgggaaaa tggagttctc cacctcagtg tgaaggcctt ccttgtaaat ctccacctga2880gatttctcat ggtgttgtag ctcacatgtc agacagttat cagtatggag aagaagttac2940gtacaaatgt tttgaaggtt ttggaattga tgggcctgca attgcaaaat gcttaggaga3000aaaatggtct caccctccat catgcataaa aacagattgt ctcagtttac ctagctttga3060aaatgccata cccatgggag agaagaagga tgtgtataag gcgggtgagc aagtgactta3120cacttgtgca acatattaca aaatggatgg agccagtaat gtaacatgca ttaatagcag3180atggacagga aggccaacat gcagagacac ctcctgtgtg aatccgccca cagtacaaaa3240tgcttatata gtgtcgagac agatgagtaa atatccatct ggtgagagag tacgttatca3300atgtaggagc ccttatgaaa tgtttgggga tgaagaagtg atgtgtttaa atggaaactg3360gacggaacca cctcaatgca aagattctac aggaaaatgt gggccccctc cacctattga3420caatggggac attacttcat tcccgttgtc agtatatgct ccagcttcat cagttgagta3480ccaatgccag aacttgtatc aacttgaggg taacaagcga ataacatgta gaaatggaca3540
atggtcagaa ccaccaaaat gcttacatcc gtgtgtaata tcccgagaaa ttatggaaaa3600ttataacata gcattaaggt ggacagccaa acagaagctt tattcgagaa caggtgaatc3660agttgaattt gtgtgtaaac ggggatatcg tctttcatca cgttctcaca cattgcgaac3720aacatgttgg gatgggaaac tggagtatcc aacttgtgca aaaagataga atcaatcata3780aagtgcacac ctttattcag aactttagta ttaaatcagt tctcaatttc attttttatg3840tattgtttta ctccttttta ttcatacgta aaattttgga ttaatttgtg aaaatgtaat3900tataagctga gaccggtggc tctctt 3926<210> 20<211> 1231<212> PRT<213> Homo sapiens<220>
<221> HÒò×Ó1¶àëÄÐòÁÐ<222> (1)..(1231)<400> 20Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys1 5 10 15Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile20 25 30Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala35 40 45
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met50 55 60Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys65 70 75 80Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe85 90 95Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr100 105 110Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu115 120 125Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile ProIle Cys Glu Val Val130 135 140Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser145 150 155 160Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe165 170 175Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys180 185 190Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile195 200 205Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys210 215 220Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly225 230 235 240
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp245 250 255Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile260 265 270Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp275 280 285Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly290 295 300Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys305 310 315 320Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr325 330 335His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr340 345 350Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr355 360 365Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro370 375 380Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln385 390 395 400Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys405 410 415His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met420 425 430
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys435 440 445Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln450 455 460Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly465 470 475 480Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Arg Cys Gly Lys485 490 495Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro500 505 510Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu515 520 525Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr530 535 540Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp545 550 555 560Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val565 570 575His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val580 585 590Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser595 600 605Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys610 615 620
Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn625 630 635 640Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu645 650 655Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln660 665 670Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu675 680 685Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu690 695 700Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser705 710 715 720Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly725 730 735Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys740 745 750Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys755 760 765Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys770 775 780Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu785 790 795 800Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln805 810 815
Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly820 825 830Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly835 840 845Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys850 855 860Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr865 870 875 880Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys885 890 895Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu900 905 910Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly915 920 925Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His930 935 940Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe945 950 955 960Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu965 970 975Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu980 985 990Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr995 1000 1005
Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys10101015 1020Met Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp Thr10251030 1035Gly Arg Pro Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr10401045 1050Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro10551060 1065Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met10701075 1080Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu10851090 1095Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro11001105 1110Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr11151120 1125Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln11301135 1140Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser11451150 1155Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile11601165 1170Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys11751180 1185
Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg11901195 1200Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys12051210 1215Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg12201225 1230<210> 21<211> 1984<212> DNA<213> Homo sapiens<220>
<221> ³¬Ñõ»¯ÎïÆç»¯Ã¸3 mRNA<222> (1)..(1984)<400> 21ggatccagag atttagattt tttataagct ttcctgccac cgaaacgggt gtttgggacc 60tcacgaggcc ctgttcattc ttcgtcgctg cgctccccac tctgtactgg atgcatttac120tgacgttgtt gtctccgtcc ccagagtatg aacccccaag gtgactcatg cagctgtggg180tgcccggcat acagcatggt gactggaatg gatgagcacc caataaacat ttgttgcagg240aatgcaggag gacgggcagg ccagcaagca ggctgcctgg tttttcccac atgggctttt300ctgggaaaga agagcttcta tttttggaaa gggctgctat gattgagaaa agttcatggc360agcaaaaaaa ggacagacgt cgggagggaa acactcctag ttctcccaga caacacattt420tttaaaaaga ctccttcatc tctttaataa taacggtaac gacaatgaca atgatgatta480
cttatgagtg cggctagtgc cagccactgt gttgtcactg ggcgagtaat gatctcattg540gatcttcacg gtgggcgtgc ggggctccag ggacagcctg cgttcctggg ctggctgggt600gcagctctct tttcaggaga gaaagctctc ttggaggagc tggaaaggtg cccgactcca660gccatgctgg cgctactgtg ttcctgcctg ctcctggcag ccggtgcctc ggacgcctgg720acgggcgagg actcggcgga gcccaactct gactcggcgg agtggatccg agacatgtac780gccaaggtca cggagatctg gcaggaggtc atgcagcggc gggacgacga cggcacgctc840cacgccgcct gccaggtgca gccgtcggcc acgctggacg ccgcgcagcc ccgggtgacc900ggcgtcgtcc tcttccggca gcttgcgccc cgcgccaagc tcgacgcctt cttcgccctg960gagggcttcc cgaccgagcc gaacagctcc agccgcgcca tccacgtgca ccagttcggg 1020gacctgagcc agggctgcga gtccaccggg ccccactaca acccgctggc cgtgccgcac 1080ccgcagcacc cgggcgactt cggcaacttc gcggtccgcg acggcagcct ctggaggtac 1140cgcgccggcc tggccgcctc gctcgcgggc ccgcactcca tcgtgggccg ggccgtggtc 1200gtccacgctg gcgaggacga cctgggccgc ggcggcaacc aggccagcgt ggagaacggg 1260aacgcgggcc ggcggctggc ctgctgcgtg gtgggcgtgt gcgggcccgg gctctgggag 1320cgccaggcgc gggagcactc agagcgcaag aagcggcggc gcgagagcga gtgcaaggcc 1380gcctgagcgc ggcccccacc cggcggcggc cagggacccc cgaggccccc ctctgccttt 1440gagcttctcc tctgctccaa cagacacctt ccactctgag gtctcacctt cgcctctgct 1500gaagtctccc cgcagccctc tccacccaga ggtctcccta taccgagacc caccatcctt 1560ccatcctgag gaccgcccca accctcggag ccccccactc agtaggtctg aaggcctcca 1620tttgtaccga aacaccccgc tcacgctgac agcctcctag gctccctgag gtacctttcc 1680acccagaccc tccttcccca ccccataagc cctgagactc ccgcctttga cctgacgatc 1740ttcccccttc ccgccttcag gttcctccta ggcgctcaga ggccgctctg gggggttgcc 1800tcgagtcccc ccacccctcc ccacccacca ccgctcccgc ggcaagccag cccgtgcaac 1860ggaagccagg ccaactgccc cgcgtcttca gctgtttcgc atccaccgcc accccactga 1920
gagctgctcc tttgggggaa tgtttggcaa cctttgtgtt acagattaaa aattcagcaa1980ttca 1984<210> 22<211> 240<212> PRT<213> Homo sapiens<220>
<221> ³¬Ñõ»¯ÎïÆç»¯Ã¸3¶àëÄÐòÁÐ<222> (1)..(240)<400> 22Met Leu Ala Leu Leu Cys Ser Cys Leu Leu Leu Ala Ala Gly Ala Ser1 5 10 15Asp Ala Trp Thr Gly Glu Asp Ser Ala Glu Pro Asn Ser Asp Ser Ala20 25 30Glu Trp Ile Arg Asp Met Tyr Ala Lys Val Thr Glu Ile Trp Gln Glu35 40 45Val Met Gln Arg Arg Asp Asp Asp Gly Thr Leu His Ala Ala Cys Gln50 55 60Val Gln Pro Ser Ala Thr Leu Asp Ala Ala Gln Pro Arg Val Thr Gly65 70 75 80Val Val Leu Phe Arg Gln Leu Ala Pro Arg Ala Lys Leu Asp Ala Phe
85 90 95Phe Ala Leu Glu Gly Phe Pro Thr Glu Pro Asn Ser Ser Ser Arg Ala100 105 110Ile His Val His Gln Phe Gly Asp Leu Ser Gln Gly Cys Glu Ser Thr115 120 125Gly Pro His Tyr Asn Pro Leu Ala Val Pro His Pro Gln His Pro Gly130 135 140Asp Phe Gly Asn Phe Ala Val Arg Asp Gly Ser Leu Trp Arg Tyr Arg145 150 155 160Ala Gly Leu Ala Ala Ser Leu Ala Gly Pro His Ser Ile Val Gly Arg165 170 175Ala Val Val Val His Ala Gly Glu Asp Asp Leu Gly Arg Gly Gly Asn180 185 190Gln Ala Ser Val Glu Asn Gly Asn Ala Gly Arg Arg Leu Ala Cys Cys195 200 205Val Val Gly Val Cys Gly Pro Gly Leu Trp Glu Arg Gln Ala Arg Glu210 215 220His Ser Glu Arg Lys Lys Arg Arg Arg Glu Ser Glu Cys Lys Ala Ala225 230 235 240<210> 23<211> 1338<212> DNA
<213> Homo sapiens<220>
<221> neuronatin mRNA<222> (1)..(1338)<400> 23taggtggcgg gcgggtactt aaggcgcggc caccgcggct gcggcagtgc gcccaacagc 60ggactccgag accagcggat ctcggcaaac cctctttctc gaccacccac ctaccattct120tggaaccatg gcggcagtgg cggcggcctc ggctgaactg ctcatcatcg gctggtacat180cttccgcgtg ctgctgcagg tgttcctgga atgctgcatt tactgggtag gattcgcttt240tcgaaatcct ccagggacac agcccattgc gagaagtgag gtgttcaggt actccctgca300gaagctggca tacacggtgt cgcggaccgg gcggcaggtg ttgggggagc gcaggcagcg360agcccccaac tgaggcccca gctcccagcc ctgggcggcc gtatcatcag gtgctcctgt420gcatctcggc cagcacggga gccagtgccg cgcaggaatg tggggtcccc tgtgttccct480cgccagagga gcacttggca aggtcagtga ggggccagta gacccccgga gaagcagtac540cgacaatgac gaagatacca gatcccttcc caaccccttt gcaccggtcc cactaagggg600cagggtcgag agaggagggg ggataggggg agcagacccc tgagatctgg gcataggcac660cgcattctga tctggacaaa gtcgggacag caccatccca gccccgaagc cagggccatg720ccagcaggcc ccaccatgga aatcaaaaca ccgcaccagc cagcagaatg gacattctga780catcgccagc cgacgccctg aatcttggtg cagcaccaac cgcgtgcctg tgtggcggga840ctggagggca cagttgagga aggagggtgg ttaagaaata cagtggggcc ctctcgctgt900cccttgccca gggcacttgc attccagcct cgctgcattt gctctctcga ttcccctttc960ctcctcactg cctcccaagc ccaccctact ccaaaataat gtgtcacttg atttggaact 1020attcaagcag taaaagtaaa tgaatcccac ctttactaaa acactttctc tgaacccccc 1080ttgcccctca ctgatcttgc ttttccctgg tctcatgcag ttgtggtcaa tattgtggta 1140
atcgctaatt gtactgattg tttaagtgtg cattagttgt gtctccccag ctagattgta1200agctcctgga ggacagggac cacctctaca aaaaataaaa aaagtacctc ccctgtctcg1260cacagtgtcc caggaccctg cggtgcagta gaggcgcacc aaaaaaaaaa aaaaaaaaaa1320aaaaaaaaaa aaaaaaaa 1338<210> 24<211> 81<212> PRT<213> Homo sapiens<220>
<221> neuronatin¶àëÄÐòÁÐ<222> (1)..(81)<400> 24Met Ala Ala Val Ala Ala Ala Ser Ala Glu Leu Leu Ile Ile Gly Trp1 5 10 15Tyr Ile Phe Arg Val Leu Leu Gln Val Phe Leu Glu Cys Cys Ile Tyr20 25 30Trp Val Gly Phe Ala Phe Arg Asn Pro Pro Gly Thr Gln Pro Ile Ala35 40 45Arg Ser Glu Val Phe Arg Tyr Ser Leu Gln Lys Leu Ala Tyr Thr Val50 55 60Ser Arg Thr Gly Arg Gln Val Leu Gly Glu Arg Arg Gln Arg Ala Pro
65 70 75 80Asn<210> 25<211> 2500<212> DNA<213> Homo sapiens<220>
<221> ÂËÅÝËØÒÖÖÆËØ-Ñù3Ìǵ°°×mRNA<222> (1)..(2500)<400> 25gttcgccatg cgtcccgggg cgccagggcc actctggcct ctgccctggg gggccctggc 60ttgggccgtg ggcttcgtga gctccatggg ctcggggaac cccgcgcccg gtggtgtttg120ctggctccag cagggccagg aggccacctg cagcctggtg ctccagactg atgtcacccg180ggccgagtgc tgtgcctccg gcaacattga caccgcctgg tccaacctca cccacccggg240gaacaagatc aacctcctcg gcttcttggg ccttgtccac tgccttccct gcaaagattc300gtgcgacggc gtggagtgcg gcccgggcaa ggcgtgccgc atgctggggg gccgcccgcg360ctgcgagtgc gcgcccgact gctcggggct cccggcgcgg ctgcaggtct gcggctcaga420cggcgccacc taccgcgacg agtgcgagct gcgcgccgcg cgctgccgcg gccacccgga480cctgagcgtc atgtaccggg gccgctgccg caagtcctgt gagcacgtgg tgtgcccgcg540gccacagtcg tgcgtcgtgg accagacggg cagcgcccac tgcgtggtgt gtcgagcggc600gccctgccct gtgccctcca gccccggcca ggagctttgc ggcaacaaca acgtcaccta660catctcctcg tgccacatgc gccaggccac ctgcttcctg ggccgctcca tcggcgtgcg720
ccacgcgggc agctgcgcag gcacccctga ggagccgcca ggtggtgagt ctgcagaaga 780ggaagagaac ttcgtgtgag cctgcaggac aggcctgggc ctggtgcccg aggcccccca 840tcatcccctg ttatttattg ccacagcaga gtctaattta tatgccacgg acactcctta 900gagcccggat tcggaccact tggggatccc agaacctccc tgacgatatc ctggaaggac 960tgaggaaggg aggcctgggg gccggctggt gggtgggata gacctgcgtt ccggacactg1020agcgcctgat ttagggccct tctctaggat gccccagccc ctaccctaag acctattgcc1080ggggaggatt ccacacttcc gctcctttgg ggataaacct attaattatt gctactatca1140agagggctgg gcattctctg ctggtaattc ctgaagaggc atgactgctt ttctcagccc1200caagcctcta gtctgggtgt gtacggaggg tctagcctgg gtgtgtacgg agggtctagc1260ctgggtgagt acggagggtc tagcctgggt gagtacggag ggtctagcct gggtgagtac1320ggagagtcta gcctgggtgt gtatggagga tctagcctgg gtgagtatgg agggtctagc1380ctgggtgagt atggagggtc tagcctgggt gtgtatggag ggtctagcct gggtgagtat1440ggagggtcta gcctgggtgt gtatggaggg tctagcctgg gtgagtatgg agggtctagc1500ctgggtgtgt acggagggtc tagtctgagt gcgtgtgggg acctcagaac actgtgacct1560tagcccagca agccaggccc ttcatgaagg ccaagaaggc tgccaccatt ccctgccagc1620ccaagaactc cagcttcccc actgcctctg tgtgcccctt tgcgtcctgt gaaggccatt1680gagaaatgcc cagtgtgccc cctgggaaag ggcacggcct gtgctcctga cacgggctgt1740gcttggccac agaaccaccc agcgtctccc ctgctgctgt ccacgtcagt tcatgaggca1800acgtcgcgtg gtctcagacg tggagcagcc agcggcagct cagagcaggg cactgtgtcc1860ggcggagcca agtccactct gggggagctc tggcggggac cacgggccac tgctcaccca1920ctggccccga ggggggtgta gacgccaaga ctcacgcatg tgtgacatcc ggagtcctgg1980agccgggtgt cccagtggca ccactaggtg cctgctgcct ccacagtggg gttcacaccc2040agggctcctt ggtcccccac aacctgcccc ggccaggcct gcagacccag actccagcca2100gacctgcctc acccaccaat gcagccgggg ctggcgacac cagccaggtg ctggtcttgg2160
gccagttctc ccacgacggc tcaccctccc ctccatctgc gttgatgctc agaatcgcct2220acctgtgcct gcgtgtaaac cacagcctca gaccagctat ggggagagga caacacggag2280gatatccagc ttccccggtc tggggtgagg agtgtgggga gcttgggcat cctcctccag2340cctcctccag cccccaggca gtgccttacc tgtggtgccc agaaaagtgc ccctaggttg2400gtgggtctac aggagcctca gccaggcagc ccaccccacc ctggggccct gcctcaccaa2460ggaaataaag actcaaagaa gccttttttt tttttttttt 2500<210> 26<211> 263<212> PRT<213> Homo sapiens<220>
<221> ÂËÅÝËØÒÖÖÆËØ-Ñù3Ìǵ°°×¶àëÄÐòÁÐ<222> (1)..(263)<400> 26Met Arg Pro Gly Ala Pro Gly Pro Leu Trp Pro Leu Pro Trp Gly Ala1 5 10 15Leu Ala Trp Ala Val Gly Phe Val Ser Ser Met Gly Ser Gly Asn Pro20 25 30Ala Pro Gly Gly Val Cys Trp Leu Gln Gln Gly Gln Glu Ala Thr Cys35 40 45Ser Leu Val Leu Gln Thr Asp Val Thr Arg Ala Glu Cys Cys Ala Ser
50 55 60Gly Asn Ile Asp Thr Ala Trp Ser Asn Leu Thr His Pro Gly Asn Lys65 70 75 80Ile Asn Leu Leu Gly Phe Leu Gly Leu Val His Cys Leu Pro Cys Lys85 90 95Asp Ser Cys Asp Gly Val Glu Cys Gly Pro Gly Lys Ala Cys Arg Met100 105 110Leu Gly Gly Arg Pro Arg Cys Glu Cys Ala Pro Asp Cys Ser Gly Leu115 120 125Pro Ala Arg Leu Gln Val Cys Gly Ser Asp Gly Ala Thr Tyr Arg Asp130 135 140Glu Cys Glu Leu Arg Ala Ala Arg Cys Arg Gly His Pro Asp Leu Ser145 150 155 160Val Met Tyr Arg Gly Arg Cys Arg Lys Ser Cys Glu His Val Val Cys165 170 175Pro Arg Pro Gln Ser Cys Val Val Asp Gln Thr Gly Ser Ala His Cys180 185 190Val Val Cys Arg Ala Ala Pro Cys Pro Val Pro Ser Ser Pro Gly Gln195 200 205Glu Leu Cys Gly Asn Asn Asn Val Thr Tyr Ile Ser Ser Cys His Met210 215 220Arg Gln Ala Thr Cys Phe Leu Gly Arg Ser Ile Gly Val Arg His Ala225 230 235 240Gly Ser Cys Ala Gly Thr Pro Glu Glu Pro Pro Gly Gly Glu Ser Ala
245 250 255Glu Glu Glu Glu Asn Phe Val260<210> 27<211> 3750<212> DNA<213> Homo sapiens<220>
<221> Ë¿°±Ëá23µ°°×ømRNA<222> (1)..(3750)<400> 27gcgctgctcg ccagcttgct cgcactcggc tgtgcggcgg ggcaggcatg ggagccgcgc 60gctctctccc ggcgcccaca cctgtctgag cggcgcagcg agccgcggcc cgggcgggct120gctcggcgcg gaacagtgct cggcatggca gggattccag ggctcctctt ccttctcttc180tttctgctct gtgctgttgg gcaagtgagc ccttacagtg ccccctggaa acccacttgg240cctgcatacc gcctccctgt cgtcttgccc cagtctaccc tcaatttagc caagccagac300tttggagccg aagccaaatt agaagtatct tcttcatgtg gaccccagtg tcataaggga360actccactgc ccacttacga agaggccaag caatatctgt cttatgaaac gctctatgcc420aatggcagcc gcacagagac gcaggtgggc atctacatcc tcagcagtag tggagatggg480gcccaacacc gagactcagg gtcttcagga aagtctcgaa ggaagcggca gatttatggc540tatgacagca ggttcagcat ttttgggaag gacttcctgc tcaactaccc tttctcaaca600tcagtgaagt tatccacggg ctgcaccggc accctggtgg cagagaagca tgtcctcaca660gctgcccact gcatacacga tggaaaaacc tatgtgaaag gaacccagaa gcttcgagtg720
ggcttcctaa agcccaagtt taaagatggt ggtcgagggg ccaacgactc cacttcagcc780atgcccgagc agatgaaatt tcagtggatc cgggtgaaac gcacccatgt gcccaagggt840tggatcaagg gcaatgccaa tgacatcggc atggattatg attatgccct cctggaactc900aaaaagcccc acaagagaaa atttatgaag attggggtga gccctcctgc taagcagctg960ccagggggca gaattcactt ctctggttat gacaatgacc gaccaggcaa tttggtgtat 1020cgcttctgtg acgtcaaaga cgagacctat gacttgctct accagcaatg cgatgcccag 1080ccaggggcca gcgggtctgg ggtctatgtg aggatgtgga agagacagca gcagaagtgg 1140gagcgaaaaa ttattggcat tttttcaggg caccagtggg tggacatgaa tggttcccca 1200caggatttca acgtggctgt cagaatcact cctctcaaat atgcccagat ttgctattgg 1260attaaaggaa actacctgga ttgtagggag gggtgacaca gtgttccctc ctggcagcaa 1320ttaagggtct tcatgttctt attttaggag aggccaaatt gttttttgtc attggcgtgc 1380acacgtgtgt gtgtgtgtgt gtgtgtgtgt aaggtgtctt ataatctttt acctatttct 1440tacaattgca agatgactgg ctttactatt tgaaaactgg tttgtgtatc atatcatata 1500tcatttaagc agtttgaagg catacttttg catagaaata aaaaaaatac tgatttgggg 1560caatgaggaa tatttgacaa ttaagttaat cttcacgttt ttgcaaactt tgatttttat 1620ttcatctgaa cttgtttcaa agatttatat taaatatttg gcatacaaga gatatgaatt 1680cttatatgtg tgcatgtgtg ttttcttctg agattcatct tggtggtggg tttttttgtt 1740tttttaattc agtgcctgat ctttaatgct tccataaggc agtgttccca tttaggaact 1800ttgacagcat ttgttaggca gaatattttg gatttggagg catttgcatg gtagtctttg 1860aacagtaaaa tgatgtgttg actatactga tacacatatt aaactatacc ttatagtaaa 1920ccagtatccc aagctgcttt tagttccaaa aatagtttct tttccaaagg ttgttgctct 1980actttgtagg aagtctttgc atatggccct cccaacttta aagtcatacc agagtggcca 2040agagtgttta tcccaaccct tccatttaac aggatttcac tcacatttct ggaactagct 2100atttttcaga agacaataat cagggcttaa ttagaacagg ctgtatttcc tcccagcaaa 2160
cagttgtggc cacactaaaa acaatcatag cattttaccc ctggattata gcacatctca2220tgttttatca tttggatgga gtaatttaaa atgaattaaa ttccagagaa caatggaagc2280attgcctggc agatgtcaca acagaataac cacttgtttg gagcctggca cagtcctcca2340gcctgatcaa aaattattct gcatagtttt cagtgtgctt tctgggagct atgtacttct2400tcaatttgga aacttttctc tctcatttat agtgaaaata cttggaagtt actttaagaa2460aaccagtgtg gcctttttcc ctctagcttt aaaagggccg cttttgctgg aatgctctag2520gttatagata aacaattagg tataatagca aaaatgaaaa ttggaagaat gcaaaatgga2580tcagaatcat gccttccaat aaaggccttt acacatgttt tatcaatatg attatcaaat2640cacagcatat acagaaaaga cttggactta ttgtatgttt ttattttatg gctctcggcc2700taagcacttc tttctaaatg tatcggagaa aaaatcaaat ggactacaag cacgtgtttg2760ctgtgcttgc accccaggta aacctgcatt gtagcaattt gtaaggatat tcagatggag2820cactgtcact tagacattct ctgggggatt ttctgcttgt ctttcttgag ctttttggaa2880ggataattct gataaggcac tcaagaaacg tacaaccaca gtgctttctt caaatcatat2940gagaaatact atgcatagca aggagatgca gagccgccag gaaaattctg agttccagca3000caattttctt tggaatctaa caggaatcta gcctgaggaa gaagggaggt ctccatttct3060atgtctggta tttgggggtt ttgtttgttt ttgctttagc ttggtgaaaa aaagttcact3120gaacaccaag accagaatgg atttttttaa aaaaatagat gttccttttg tgaagcacct3180tgattccttg attttgattt tttgcaaagt tagacaatgg cacaaagtca aaatgaaatc3240aatgtttagt tcacaagtag atgtaattta ctaaagaatg atacacccat atgctatata3300cagcttaact cacagaactg taaaagaaaa ttataaaata attcaacatg tccatctttt3360tagtgataat aaaagaaagc atggtattaa actatcatag aagtagacag aaaaagaaaa3420aaggactcat ggcattatta atataattag tgctttacat gtgttagtta tacatattag3480aagcatattt gcctagtaag gctagtagaa ccacatttcc caaagtgtgc tccttaaaca3540ctcatgcctt atgattttct accaaaagta aaaagggttg tattaagtca gaggaagatg3600
cctctccatt ttccctctct ttatcagagg ttcacatgcc tgtctgcaca ttaaaagctc3660tgggaagacc tgttgtaaag ggacaagttg aggttgtaaa atctgcattt aaataaacat3720ctttgatcac aaaaaaaaaa aaaaaaaaaa 3750<210> 28<211> 383<212> PRT<213> Homo sapiens<220>
<221> Ë¿°±Ëá23µ°°×ø¶àëÄÐòÁÐ<222> (1)..(383)<400> 28Met Ala Gly Ile Pro Gly Leu Leu Phe Leu Leu Phe Phe Leu Leu Cys1 5 10 15Ala Val Gly Gln Val Ser Pro Tyr Ser Ala Pro Trp Lys Pro Thr Trp20 25 30Pro Ala Tyr Arg Leu Pro Val Val Leu Pro Gln Ser Thr Leu Asn Leu35 40 45Ala Lys Pro Asp Phe Gly Ala Glu Ala Lys Leu Glu Val Ser Ser Ser50 55 60Cys Gly Pro Gln Cys His Lys Gly Thr Pro Leu Pro Thr Tyr Glu Glu65 70 75 80Ala Lys Gln Tyr Leu Ser Tyr Glu Thr Leu Tyr Ala Asn Gly Ser Arg
85 90 95Thr Glu Thr Gln Val Gly Ile Tyr Ile Leu Ser Ser Ser Gly Asp Gly100 105 110Ala Gln His Arg Asp Ser Gly Ser Ser Gly Lys Ser Arg Arg Lys Arg115 120 125Gln Ile Tyr Gly Tyr Asp Ser Arg Phe Ser Ile Phe Gly Lys Asp Phe130 135 140Leu Leu Asn Tyr Pro Phe Ser Thr Ser Val Lys Leu Ser Thr Gly Cys145 150 155 160Thr Gly Thr Leu Val Ala Glu Lys His Val Leu Thr Ala Ala His Cys165 170 175Ile His Asp Gly Lys Thr Tyr Val Lys Gly Thr Gln Lys Leu Arg Val180 185 190Gly Phe Leu Lys Pro Lys Phe Lys Asp Gly Gly Arg Gly Ala Asn Asp195 200 205Ser Thr Ser Ala Met Pro Glu Gln Met Lys Phe Gln Trp Ile Arg Val210 215 220Lys Arg Thr His Val Pro Lys Gly Trp Ile Lys Gly Asn Ala Asn Asp225 230 235 240Ile Gly Met Asp Tyr Asp Tyr Ala Leu Leu Glu Leu Lys Lys Pro His245 250 255Lys Arg Lys Phe Met Lys Ile Gly Val Ser Pro Pro Ala Lys Gln Leu260 265 270Pro Gly Gly Arg Ile His Phe Ser Gly Tyr Asp Asn Asp Arg Pro Gly
275 280 285Asn Leu Val Tyr Arg Phe Cys Asp Val Lys Asp Glu Thr Tyr Asp Leu290 295 300Leu Tyr Gln Gln Cys Asp Ala Gln Pro Gly Ala Ser Gly Ser Gly Val305 310 315 320Tyr Val Arg Met Trp Lys Arg Gln Gln Gln Lys Trp Glu Arg Lys Ile325 330 335Ile Gly Ile Phe Ser Gly His Gln Trp Val Asp Met Asn Gly Ser Pro340 345 350Gln Asp Phe Asn Val Ala Val Arg Ile Thr Pro Leu Lys Tyr Ala Gln355 360 365Ile Cys Tyr Trp Ile Lys Gly Asn Tyr Leu Asp Cys Arg Glu Gly370 375 380<210> 29<211> 1362<212> DNA<213> Homo sapiens<220>
<221> ĤÁªµ°°×2 mRNA<222> (1)..(1362)<223> ͬÒå´Ê֬ƤÖʵ°°×II
<400> 29catttgggga cgctctcagc tctcggcgca cggcccagct tccttcaaaa tgtctactgt 60tcacgaaatc ctgtgcaagc tcagcttgga gggtgatcac tctacacccc caagtgcata120tgggtctgtc aaagcctata ctaactttga tgctgagcgg gatgctttga acattgaaac180agccatcaag accaaaggtg tggatgaggt caccattgtc aacattttga ccaaccgcag240caatgcacag agacaggata ttgccttcgc ctaccagaga aggaccaaaa aggaacttgc300atcagcactg aagtcagcct tatctggcca cctggagacg gtgattttgg gcctattgaa360gacacctgct cagtatgacg cttctgagct aaaagcttcc atgaaggggc tgggaaccga420cgaggactct ctcattgaga tcatctgctc cagaaccaac caggagctgc aggaaattaa480cagagtctac aaggaaatgt acaagactga tctggagaag gacattattt cggacacatc540tggtgacttc cgcaagctga tggttgccct ggcaaagggt agaagagcag aggatggctc600tgtcattgat tatgaactga ttgaccaaga tgctcgggat ctctatgacg ctggagtgaa660gaggaaagga actgatgttc ccaagtggat cagcatcatg accgagcgga gcgtgcccca720cctccagaaa gtatttgata ggtacaagag ttacagccct tatgacatgt tggaaagcat780caggaaagag gttaaaggag acctggaaaa tgctttcctg aacctggttc agtgcattca840gaacaagccc ctgtattttg ctgatcggct gtatgactcc atgaagggca aggggacgcg900agataaggtc ctgatcagaa tcatggtctc ccgcagtgaa gtggacatgt tgaaaattag960gtctgaattc aagagaaagt acggcaagtc cctgtactat tatatccagc aagacactaa 1020gggcgactac cagaaagcgc tgctgtacct gtgtggtgga gatgactgaa gcccgacacg 1080gcctgagcgt ccagaaatgg tgctcaccat gcttccagct aacaggtcta gaaaaccagc 1140ttgcgaataa cagtccccgt ggccatccct gtgagggtga cgttagcatt acccccaacc 1200tcattttagt tgcctaagca ttgcctggcc ttcctgtcta gtctctcctg taagccaaag 1260aaatgaacat tccaaggagt tggaagtgaa gtctatgatg tgaaacactt tgcctcctgt 1320gtactgtgtc ataaacagat gaataaactg aatttgtact tt 1362
<210> 30<211> 339<212> PRT<213> Homo sapiens<220>
<221> ĤÁªµ°°×2¶àëÄÐòÁÐ<222> (1)..(339)<400> 30Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp1 5 10 15His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr Asn20 25 30Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys Thr35 40 45Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg Ser50 55 60Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg Thr Lys65 70 75 80Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu Glu85 90 95Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala Ser
100 105 110Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser Leu115 120 125Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile Asn130 135 140Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile Ile145 150 155 160Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala Lys165 170 175Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile Asp180 185 190Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly Thr195 200 205Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro His210 215 220Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp Met225 230 235 240Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala Phe245 250 255Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe Ala Asp260 265 270Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val Leu275 280 285Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys Ile Arg
290 295 300Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln305 310 315 320Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu Cys Gly325 330 335Gly Asp Asp<210> 31<211> 1946<212> DNA<213> Homo sapiens<220>
<221> LOX mRNA<222> (1)..(1946)<400> 31agacactgcc cgctctccgg gactccgcgc cgctccccgt tgccttccag gactgagaaa 60ggggaaaggg aagggtgcca cgtccgagca gccgccttga ctggggaagg gtctgaatcc120cacccttggc attgcttggt ggagactgag atacccgtgc tccgctcgcc tccttggttg180aagatttctc cttccctcac gtgatttgag ccccgttttt attttctgtg agccacgtcc240tcctcgagcg gggtcaatct ggcaaaagga gtgatgcgct tcgcctggac cgtgctcctg300ctcgggcctt tgcagctctg cgcgctagtg cactgcgccc ctcccgccgc cggccaacag360cagcccccgc gcgagccgcc ggcggctccg ggcgcctggc gccagcagat ccaatgggag420aacaacgggc aggtgttcag cttgctgagc ctgggctcac agtaccagcc tcagcgccgc480cgggacccgg gcgccgccgt ccctggtgca gccaacgcct ccgcccagca gccccgcact540
ccgatcctgc tgatccgcga caaccgcacc gccgcggcgc gaacgcggac ggccggctca600tctggagtca ccgctggccg ccccaggccc accgcccgtc actggttcca agctggctac660tcgacatcta gagcccgcga agctggcgcc tcgcgcgcgg agaaccagac agcgccggga720gaagttcctg cgctcagtaa cctgcggccg cccagccgcg tggacggcat ggtgggcgac780gacccttaca acccctacaa gtactctgac gacaaccctt attacaacta ctacgatact840tatgaaaggc ccagacctgg gggcaggtac cggcccggat acggcactgg ctacttccag900tacggtctcc cagacctggt ggccgacccc tactacatcc aggcgtccac gtacgtgcag960aagatgtcca tgtacaacct gagatgcgcg gcggaggaaa actgtctggc cagtacagca 1020tacagggcag atgtcagaga ttatgatcac agggtgctgc tcagatttcc ccaaagagtg 1080aaaaaccaag ggacatcaga tttcttaccc agccgaccaa gatattcctg ggaatggcac 1140agttgtcatc aacattacca cagtatggat gagtttagcc actatgacct gcttgatgcc 1200aacacccaga ggagagtggc tgaaggccac aaagcaagtt tctgtcttga agacacatcc 1260tgtgactatg gctaccacag gcgatttgca tgtactgcac acacacaggg attgagtcct 1320ggctgttatg atacctatgg tgcagacata gactgccagt ggattgatat tacagatgta 1380aaacctggaa actatatcct aaaggtcagt gtaaacccca gctacctggt tcctgaatct 1440gactatacca acaatgttgt gcgctgtgac attcgctaca caggacatca tgcgtatgcc 1500tcaggctgca caatttcacc gtattagaag gcaaagcaaa actcccaatg gataaatcag 1560tgcctggtgt tctgaagtgg gaaaaaatag actaacttca gtaggattta tgtattttga 1620aaaagagaac agaaaacaac aaaagaattt ttgtttggac tgttttcaat aacaaagcac 1680ataactggat tttgaacgct taagtcatca ttacttggga aatttttaat gtttattatt 1740tacatcactt tgtgaattaa cacagtgttt caattctgta attacatatt tgactctttc 1800aaagaaatcc aaatttctca tgttcctttt gaaattgtag tgcaaaatgg tcagtattat 1860ctaaatgaat gagccaaaat gactttgaac tgaaactttt ctaaagtgct ggaactttag 1920tgaaacataa taataatggg tttata1946
<210> 32<211> 417<212> PRT<213> Homo sapiens<220>
<221> LOX¶àëÄÐòÁÐ<222> (1)..(417)<400> 32Met Arg Phe Ala Trp Thr Val Leu Leu Leu Gly Pro Leu Gln Leu Cys1 5 10 15Ala Leu Val His Cys Ala Pro Pro Ala Ala Gly Gln Gln Gln Pro Pro20 25 30Arg Glu Pro Pro Ala Ala Pro Gly Ala Trp Arg Gln Gln Ile Gln Trp35 40 45Glu Asn Asn Gly Gln Val Phe Ser Leu Leu Ser Leu Gly Ser Gln Tyr50 55 60Gln Pro Gln Arg Arg Arg Asp Pro Gly Ala Ala Val Pro Gly Ala Ala65 70 75 80Asn Ala Ser Ala Gln Gln Pro Arg Thr Pro Ile Leu Leu Ile Arg Asp85 90 95Asn Arg Thr Ala Ala Ala Arg Thr Arg Thr Ala Gly Ser Ser Gly Val
100 105 110Thr Ala Gly Arg Pro Arg Pro Thr Ala Arg His Trp Phe Gln Ala Gly115 120 125Tyr Ser Thr Ser Arg Ala Arg Glu Ala Gly Ala Ser Arg Ala Glu Asn130 135 140Gln Thr Ala Pro Gly Glu Val Pro Ala Leu Ser Asn Leu Arg Pro Pro145 150 155 160Ser Arg Val Asp Gly Met Val Gly Asp Asp Pro Tyr Asn Pro Tyr Lys165 170 175Tyr Ser Asp Asp Asn Pro Tyr Tyr Asn Tyr Tyr Asp Thr Tyr Glu Arg180 185 190Pro Arg Pro Gly Gly Arg Tyr Arg Pro Gly Tyr Gly Thr Gly Tyr Phe195 200 205Gln Tyr Gly Leu Pro Asp Leu Val Ala Asp Pro Tyr Tyr Ile Gln Ala210 215 220Ser Thr Tyr Val Gln Lys Met Ser Met Tyr Asn Leu Arg Cys Ala Ala225 230 235 240Glu Glu Asn Cys Leu Ala Ser Thr Ala Tyr Arg Ala Asp Val Arg Asp245 250 255Tyr Asp His Arg Val Leu Leu Arg Phe Pro Gln Arg Val Lyg Asn Gln260 265 270Gly Thr Ser Asp Phe Leu Pro Ser Arg Pro Arg Tyr Ser Trp Glu Trp275 280 285His Ser Cys His Gln His Tyr His Ser Met Asp Glu Phe Ser His Tyr
290 295 300Asp Leu Leu Asp Ala Asn Thr Gln Arg Arg Val Ala Glu Gly His Lys305 310 315 320Ala Ser Phe Cys Leu Glu Asp Thr Ser Cys Asp Tyr Gly Tyr His Arg325 330 335Arg Phe Ala Cys Thr Ala His Thr Gln Gly Leu Ser Pro Gly Cys Tyr340 345 350Asp Thr Tyr Gly Ala Asp Ile Asp Cys Gln Trp Ile Asp Ile Thr Asp355 360 365Val Lys Pro Gly Asn Tyr Ile Leu Lys Val Ser Val Asn Pro Ser Tyr370 375 380Leu Val Pro Glu Ser Asp Tyr Thr Asn Asn Val Val Arg Cys Asp Ile385 390 395 400Arg Tyr Thr Gly His His Ala Tyr Ala Ser Gly Cys Thr Ile Ser Pro405 410 415Tyr<210> 33<211> 1600<212> DNA<213> Homo sapiens<220>
<221> ECGF 1 mRNA<222> (1)..(1600)
<400> 33gccccgccgc cggcagtgga ccgctgtgcg cgaaccctga accctacggt cccgacccgc 60gggcgaggcc gggtacctgg gctgggatcc ggagcaagcg ggcgagggca gcgccctaag120caggcccgga gcgatggcag ccttgatgac cccgggaacc ggggccccac ccgcgcctgg180tgacttctcc ggggaaggga gccagggact tcccgaccct tcgccagagc ccaagcagct240cccggagctg atccgcatga agcgagacgg aggccgcctg agcgaagcgg acatcagggg300cttcgtggcc gctgtggtga atgggagcgc gcagggcgca cagatcgggg ccatgctgat360ggccatccga cttcggggca tggatctgga ggagacctcg gtgctgaccc aggccctggc420tcagtcggga cagcagctgg agtggccaga ggcctggcgc cagcagcttg tggacaagca480ttccacaggg ggtgtgggtg acaaggtcag cctggtcctc gcacctgccc tggcggcatg540tggctgcaag gtgccaatga tcagcggacg tggtctgggg cacacaggag gcaccttgga600taagctggag tctattcctg gattcaatgt catccagagc ccagagcaga tgcaagtgct660gctggaccag gcgggctgct gtatcgtggg tcagagtgag cagctggttc ctgcggacgg720aatcctatat gcagccagag atgtgacagc caccgtggac agcctgccac tcatcacagc780ctccattctc agtaagaaac tcgtggaggg gctgtccgct ctggtggtgg acgttaagtt840cggaggggcc gccgtcttcc ccaaccagga gcaggcccgg gagctggcaa agacgctggt900tggcgtggga gccagcctag ggcttcgggt cgcggcagcg ctgaccgcca tggacaagcc960cctgggtcgc tgcgtgggcc acgccctgga ggtggaggag gcgctgctct gcatggacgg 1020cgcaggcccg ccagacttaa gggacctggt caccacgctc gggggcgccc tgctctggct 1080cagcggacac gcggggactc aggctcaggg cgctgcccgg gtggccgcgg cgctggacga 1140cggctcggcc cttggccgct tcgagcggat gctggcggcg cagggcgtgg atcccggtct 1200ggcccgagcc ctgtgctcgg gaagtcccgc agaacgccgg cagctgctgc ctcgcgcccg 1260ggagcaggag gagctgctgg cgcccgcaga tggcaccgtg gagctggtcc gggcgctgcc 1320gctggcgctg gtgctgcacg agctcggggc cgggcgcagc cgcgctgggg agccgctccg 1380
cctgggggtg ggcgcagagc tgctggtcga cgtgggtcag aggctgcgcc gtgggacccc1440ctggctccgc gtgcaccggg acggccccgc gctcagcggc ccgcagagcc gcgccctgca1500ggaggcgctc gtactctccg accgcgcgcc attcgccgcc ccctcgccct tcgcagagct1560cgttctgccg ccgcagcaat aaagctcctt tgccgcgaaa 1600<210> 34<211> 482<212> PRT<213> Homo sapiens<220>
<221> ECGF1¶àëÄÐòÁÐ<222> (1)..(482)<400> 34Met Ala Ala Leu Met Thr Pro Gly Thr Gly Ala Pro Pro Ala Pro Gly1 5 10 15Asp Phe Ser Gly Glu Gly Ser Gln Gly Leu Pro Asp Pro Ser Pro Glu20 25 30Pro Lys Gln Leu Pro Glu Leu Ile Arg Met Lys Arg Asp Gly Gly Arg35 40 45Leu Ser Glu Ala Asp Ile Arg Gly Phe Val Ala Ala Val Val Asn Gly50 55 60Ser Ala Gln Gly Ala Gln Ile Gly Ala Met Leu Met Ala Ile Arg Leu65 70 75 80
Arg Gly Met Asp Leu Glu Glu Thr Ser Val Leu Thr Gln Ala Leu Ala85 90 95Gln Ser Gly Gln Gln Leu Glu Trp Pro Glu Ala Trp Arg Gln Gln Leu100 105 110Val Asp Lys His Ser Thr Gly Gly Val Gly Asp Lys Val Ser Leu Val115 120 125Leu Ala Pro Ala Leu Ala Ala Cys Gly Cys Lys Val Pro Met Ile Ser130 135 140Gly Arg Gly Leu Gly His Thr Gly Gly Thr Leu Asp Lys Leu Glu Ser145 150 155 160Ile Pro Gly Phe Asn Val Ile Gln Ser Pro Glu Gln Met Gln Val Leu165 170 175Leu Asp Gln Ala Gly Cys Cys Ile Val Gly Gln Ser Glu Gln Leu Val180 185 190Pro Ala Asp Gly Ile Leu Tyr Ala Ala Arg Asp Val Thr Ala Thr Val195 200 205Asp Ser Leu Pro Leu Ile Thr Ala Ser Ile Leu Ser Lys Lys Leu Val210 215 220Glu Gly Leu Ser Ala Leu Val Val Asp Val Lys Phe Gly Gly Ala Ala225 230 235 240Val Phe Pro Asn Gln Glu Gln Ala Arg Glu Leu Ala Lys Thr Leu Val245 250 255Gly Val Gly Ala Ser Leu Gly Leu Arg Val Ala Ala Ala Leu Thr Ala260 265 270
Met Asp Lys Pro Leu Gly Arg Cys Val Gly His Ala Leu Glu Val Glu275 280 285Glu Ala Leu Leu Cys Met Asp Gly Ala Gly Pro Pro Asp Leu Arg Asp290 295 300Leu Val Thr Thr Leu Gly Gly Ala Leu Leu Trp Leu Ser Gly His Ala305 310 315 320Gly Thr Gln Ala Gln Gly Ala Ala Arg Val Ala Ala Ala Leu Asp Asp325 330 335Gly Ser Ala Leu Gly Arg Phe Glu Arg Met Leu Ala Ala Gln Gly Val340 345 350Asp Pro Gly Leu Ala Arg Ala Leu Cys Ser Gly Ser Pro Ala Glu Arg355 360 365Arg Gln Leu Leu Pro Arg Ala Arg Glu Gln Glu Glu Leu Leu Ala Pro370 375 380Ala Asp Gly Thr Val Glu Leu Val Arg Ala Leu Pro Leu Ala Leu Val385 390 395 400Leu His Glu Leu Gly Ala Gly Arg Ser Arg Ala Gly Glu Pro Leu Arg405 410 415Leu Gly Val Gly Ala Glu Leu Leu Val Asp Val Gly Gln Arg Leu Arg420 425 430Arg Gly Thr Pro Trp Leu Arg Val His Arg Asp Gly Pro Ala Leu Ser435 440 445Gly Pro Gln Ser Arg Ala Leu Gln Glu Ala Leu Val Leu Ser Asp Arg450 455 460
Ala Pro Phe Ala Ala Pro Ser Pro Phe Ala Glu Leu Val Leu Pro Pro465 470 475 480Gln Gln
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