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<221>²¹Ìå³É·Ö4A<222>(1)..(5417)<223>NM007293<400>3agaaggtagc agacagacag acggatctaa cctctcttgg atcctccagc catgaggctg 60ctctgggggc tgatctgggc atccagcttc ttcaccttat ctctgcagaa gcccaggttg120ctcttgttct ctccttctgt ggttcatctg ggggtccccc tatcggtggg ggtgcagctc180
caggatgtgc cccgaggaca ggtagtgaaa ggatcagtgt tcctgagaaa cccatctcgt 240aataatgtcc cctgctcccc aaaggtggac ttcaccctta gctcagaaag agacttcgca 300ctcctcagtc tccaggtgcc cttgaaagat gcgaagagct gtggcctcca tcaactcctc 360agaggccctg aggtccagct ggtggcccat tcgccatggc taaaggactc tctgtccaga 420acgacaaaca tccagggtat caacctgctc ttctcctctc gccgggggca cctctttttg 480cagacggacc agcccattta caaccctggc cagcgggttc ggtaccgggt ctttgctctg 540gatcagaaga tgcgcccgag cactgacacc atcacagtca tggtggagaa ctctcacggc 600ctccgcgtgc ggaagaagga ggtgtacatg ccctcgtcca tcttccagga tgactttgtg 660atcccagaca tctcagagcc agggacctgg aagatctcag cccgattctc agatggcctg 720gaatccaaca gcagcaccca gtttgaggtg aagaaatatg tccttcccaa ctttgaggtg 780aagatcaccc ctggaaagcc ctacatcctg acggtgccag gccatcttga tgaaatgcag 840ttagacatcc aggccaggta catctatggg aagccagtgc agggggtggc atatgtgcgc 900tttgggctcc tagatgagga tggtaagaag actttctttc gggggctgga gagtcagacc 960aagctggtga atggacagag ccacatttcc ctctcaaagg cagagttcca ggacgccctg1020gagaagctga atatgggcat tactgacctc caggggctgc gcctctacgt tgctgcagcc1080atcattgagt ctccaggtgg ggagatggag gaggcagagc tcacatcctg gtattttgtg1140tcatctccct tctccttgga tcttagcaag accaagcgac accttgtgcc tggggccccc1200ttcctgctgc aggccttggt ccgtgagatg tcaggctccc cagcttctgg cattcctgtc1260aaagtttctg ccacggtgtc ttctcctggg tctgttcctg aagcccagga cattcagcaa1320aacacagacg ggagcggcca agtcagcatt ccaataatta tccctcagac catctcagag1380ctgcagctct cagtatctgc aggctcccca catccagcga tagccaggct cactgtggca1440gccccacctt caggaggccc cgggtttctg tctattgagc ggccggattc tcgacctcct1500cgtgttgggg acactctgaa cctgaacttg cgagccgtgg gcagtggggc caccttttct1560cattactact acatgatcct atcccgaggg cagatcgtgt tcatgaatcg agagcccaag1620
aggaccctga cctcggtctc ggtgtttgtg gaccatcacc tggcaccctc cttctacttt1680gtggccttct actaccatgg agaccaccca gtggccaact ccctgcgagt ggatgtccag1740gctggggcct gcgagggcaa gctggagctc agcgtggacg gtgccaagca gtaccggaac1800ggggagtccg tgaagctcca cttagaaacc gactccctag ccctggtggc gctgggagcc1860ttggacacag ctctgtatgc tgcaggcagc aagtcccaca agcccctcaa catgggcaag1920gtctttgaag ctatgaacag ctatgacctc ggctgtggtc ctgggggtgg ggacagtgcc1980cttcaggtgt tccaggcagc gggcctggcc ttttctgatg gagaccagtg gaccttatcc2040agaaagagac taagctgtcc caaggagaag acaacccgga aaaagagaaa cgtgaacttc2100caaaaggcga ttaatgagaa attgggtcag tatgcttccc cgacagccaa gcgctgctgc2160caggatgggg tgacacgtct gcccatgatg cgttcctgcg agcagcgggc agcccgcgtg2220cagcagccgg actgccggga gcccttcctg tcctgctgcc aatttgctga gagtctgcgc2280aagaagagca gggacaaggg ccaggcgggc ctccaacgag ccctggagat cctgcaggag2340gaggacctga ttgatgagga tgacattccc gtgcgcagct tcttcccaga gaactggctc2400tggagagtgg aaacagtgga ccgctttcaa atattgacac tgtggctccc cgactctctg2460accacgtggg agatccatgg cctgagcctg tccaaaacca aaggcctatg tgtggccacc2520ccagtccagc tccgggtgtt ccgcgagttc cacctgcacc tccgcctgcc catgtctgtc2580cgccgctttg agcagctgga gctgcggcct gtcctctata actacctgga taaaaacctg2640actgtgagcg tccacgtgtc cccagtggag gggctgtgcc tggctggggg cggagggctg2700gcccagcagg tgctggtgcc tgcgggctct gcccggcctg ttgccttctc tgtggtgccc2760acggcagccg ccgctgtgtc tctgaaggtg gtggctcgag ggtccttcga attccctgtg2820ggagatgcgg tgtccaaggt tctgcagatt gagaaggaag gggccatcca tagagaggag2880ctggtctatg aactcaaccc cttggaccac cgaggccgga ccttggaaat acctggcaac2940tctgatccca atatgatccc tgatggggac tttaacagct acgtcagggt tacagcctca3000gatccattgg acactttagg ctctgagggg gccttgtcac caggaggcgt ggcctccctc3060
ttgaggcttc ctcgaggctg tggggagcaa accatgatct acttggctcc gacactggct3120gcttcccgct acctggacaa gacagagcag tggagcacac tgcctcccga gaccaaggac3180cacgccgtgg atctgatcca gaaaggctac atgcggatcc agcagtttcg gaaggcggat3240ggttcctatg cggcttggtt gtcacgggac agcagcacct ggctcacagc ctttgtgttg3300aaggtcctga gtttggccca ggagcaggta ggaggctcgc ctgagaaact gcaggagaca3360tctaactggc ttctgtccca gcagcaggct gacggctcgt tccaggaccc ctgtccagtg3420ttagacagga gcatgcaggg gggtttggtg ggcaatgatg agactgtggc actcacagcc3480tttgtgacca tcgcccttca tcatgggctg gccgtcttcc aggatgaggg tgcagagcca3540ttgaagcaga gagtggaagc ctccatctca aaggcaaact catttttggg ggagaaagca3600agtgctgggc tcctgggtgc ccacgcagct gccatcacgg cctatgccct gtcactgacc3660aaggcgcctg tggacctgct cggtgttgcc cacaacaacc tcatggcaat ggcccaggag3720actggagata acctgtactg gggctcagtc actggttctc agagcaatgc cgtgtcgccc3780accccggctc ctcgcaaccc atccgacccc atgccccagg ccccagccct gtggattgaa3840accacagcct acgccctgct gcacctcctg cttcacgagg gcaaagcaga gatggcagac3900caggcttcgg cctggctcac ccgtcagggc agcttccaag ggggattccg cagtacccaa3960gacacggtga ttgccctgga tgccctgtct gcctactgga ttgcctccca caccactgag4020gagaggggtc tcaatgtgac tctcagctcc acaggccgga atgggttcaa gtcccacgcg4080ctgcagctga acaaccgcca gattcgcggc ctggaggagg agctgcagtt ttccttgggc4140agcaagatca atgtgaaggt gggaggaaac agcaaaggaa ccctgaaggt ccttcgtacc4200tacaatgtcc tggacatgaa gaacacgacc tgccaggacc tacagataga agtgacagtc4260aaaggccacg tcgagtacac gatggaagca aacgaggact atgagtacga tgagcttcca4320gccaaggatg acccagatgc ccctctgcag cccgtgacac ccctgcagct gtttgagggt4380cggaggaacc gccgcaggag ggaggcgccc aaggtggtgg aggagcagga gtccagggtg4440cactacaccg tgtgcatctg gcggaacggc aaggtggggc tgtctggcat ggccatcgcg4500
gacgtcaccc tcctgagtgg attccacgcc ctgcgtgctg acctggagaa gctgacctcc4560ctctctgacc gttacgtgag tcactttgag accgaggggc cccacgtcct gctgtatttt4620gactcggtcc ccacctcccg ggagtgcgtg ggctttgagg ctgtgcagga agtgccggtg4680gggctggtgc agccggccag cgcaaccctg tacgactact acaaccccga gcgcagatgt4740tctgtgtttt acggggcacc aagtaagagc agactcttgg ccaccttgtg ttctgctgaa4800gtctgccagt gtgctgaggg gaagtgccct cgccagcgtc gcgccctgga gcggggtctg4860caggacgagg atggctacag gatgaagttt gcctgctact acccccgtgt ggagtacggc4920ttccaggtta aggttctccg agaagacagc agagctgctt tccgcctctt tgagaccaag4980atcacccaag tcctgcactt caccaaggat gtcaaggccg ctgctaatca gatgcgcaac5040ttcctggttc gagcctcctg ccgccttcgc ttggaacctg ggaaagaata tttgatcatg5100ggtctggatg gggccaccta tgacctcgag ggacaccccc agtacctgct ggactcgaat5160agctggatcg aggagatgcc ctctgaacgc ctgtgccgga gcacccgcca gcgggcagcc5220tgtgcccagc tcaacgactt cctccaggag tatggcactc aggggtgcca ggtgtgaggg5280ctgccctccc acctccgctg ggaggaacct gaacctggga accatgaagc tggaagcact5340gctgtgtccg ctttcatgaa cacagcctgg gaccagggca tattaaaggc ttttggcagc5400aaagtgtcag tgttggc 5417<210>4<211>1741<212>PRT<213>ÈË<220>
<221>²¹Ìå³É·Ö4A<222>(1)..(1741)
<223>NP009224<400>4Met Arg Leu Leu Trp Gly Leu Ile Trp Ala Ser Ser Phe Phe Thr Leu1 5 10 15Ser Leu Gln Lys Pro Arg Leu Leu Leu Phe Ser Pro Ser Val Val His20 25 30Leu Gly Val Pro Leu Ser Val Gly Val Gln Leu Gln Asp Val Pro Arg35 40 45Gly Gln Val Val Lys Gly Ser Val Phe Leu Arg Asn Pro Ser Arg Asn50 55 60Asn Val Pro Cys Ser Pro Lys Val Asp Phe Thr Leu Ser Ser Glu Arg65 70 75 80Asp Phe Ala Leu Leu Ser Leu Gln Val Pro Leu Lys Asp Ala Lys Ser85 90 95Cys Gly Leu His Gln Leu Leu Arg Gly Pro Glu Val Gln Leu Val Ala100 105 110His Ser Pro Trp Leu Lys Asp Ser Leu Ser Arg Thr Thr Asn Ile Gln115 120 125Gly Ile Asn Leu Leu Phe Ser Ser Arg Arg Gly His Leu Phe Leu Gln130 135 140Thr Asp Gln Pro Ile Tyr Asn Pro Gly Gln Arg Val Arg Tyr Arg Val145 150 155 160Phe Ala Leu Asp Gln Lys Met Arg Pro Ser Thr Asp Thr Ile Thr Val
165 170 175Met Val Glu Asn Ser His Gly Leu Arg Val Arg Lys Lys Glu Val Tyr180 185 190Met Pro Ser Ser Ile Phe Gln Asp Asp Phe Val Ile Pro Asp Ile Ser195 200 205Glu Pro Gly Thr Trp Lys Ile Ser Ala Arg Phe Ser Asp Gly Leu Glu210 215 220Ser Asn Ser Ser Thr Gln Phe Glu Val Lys Lys Tyr Val Leu Pro Asn225 230 235 240Phe Glu Val Lys Ile Thr Pro Gly Lys Pro Tyr Ile Leu Thr Val Pro245 250 255Gly His Leu Asp Glu Met Gln Leu Asp Ile Gln Ala Arg Tyr Ile Tyr260 265 270Gly Lys Pro Val Gln Gly Val Ala Tyr Val Arg Phe Gly Leu Leu Asp275 280 285Glu Asp Gly Lys Lys Thr Phe Phe Arg Gly Leu Glu Ser Gln Thr Lys290 295 300Leu Val Asn Gly Gln Ser His Ile Ser Leu Ser Lys Ala Glu Phe Gln305 310 315 320Asp Ala Leu Glu Lys Leu Asn Met Gly Ile Thr Asp Leu Gln Gly Leu325 330 335Arg Leu Tyr Val Ala Ala Ala Ile Ile Glu Ser Pro Gly Gly Glu Met340 345 350Glu Glu Ala Glu Leu Thr Ser Trp Tyr Phe Val Ser Ser Pro Phe Ser
355 360 365Leu Asp Leu Ser Lys Thr Lys Arg His Leu Val Pro Gly Ala Pro Phe370 375 380Leu Leu Gln Ala Leu Val Arg Glu Met Ser Gly Ser Pro Ala Ser Gly385 390 395 400Ile Pro Val Lys Val Ser Ala Thr Val Ser Ser Pro Gly Ser Val Pro405 410 415Glu Ala Gln Asp Ile Gln Gln Asn Thr Asp Gly Ser Gly Gln Val Ser420 425 430Ile Pro Ile Ile Ile Pro Gln Thr Ile Ser Glu Leu Gln Leu Ser Val435 440 445Ser Ala Gly Ser Pro His Pro Ala Ile Ala Arg Leu Thr Val Ala Ala450 455 460Pro Pro Ser Gly Gly Pro Gly Phe Leu Ser Ile Glu Arg Pro Asp Ser465 470 475 480Arg Pro Pro Arg Val Gly Asp Thr Leu Asn Leu Asn Leu Arg Ala Val485 490 495Gly Ser Gly Ala Thr Phe Ser His Tyr Tyr Tyr Met Ile Leu Ser Arg500 505 510Gly Gln Ile Val Phe Met Asn Arg Glu Pro Lys Arg Thr Leu Thr Ser515 520 525Val Ser Val Phe Val Asp His His Leu Ala Pro Ser Phe Tyr Phe Val530 535 540Ala Phe Tyr Tyr His Gly Asp His Pro Val Ala Asn Ser Leu Arg Val
545 550 555 560Asp Val Gln Ala Gly Ala Cys Glu Gly Lys Leu G1u Leu Ser Val Asp565 570575Gly Ala Lys Gln Tyr Arg Asn Gly Glu Ser Val Lys Leu His Leu Glu580 585 590Thr Asp Ser Leu Ala Leu Val Ala Leu Gly A1a Leu Asp Thr Ala Leu595 600 605Tyr Ala Ala Gly Ser Lys Ser His Lys Pro Leu Asn Met Gly Lys Val610 615 620Phe Glu Ala Met Asn Ser Tyr Asp Leu G1y Cys GLy Pro Gly Gly Gly625 630 635 640Asp Ser Ala Leu Gln Val Phe Gln Ala Ala Gly Leu Ala Phe Ser Asp645 650 655Gly Asp Gln Trp Thr Leu Ser Arg Lys Arg Leu Ser Cys Pro Lys Glu660 665 670Lys Thr Thr Arg Lys Lys Arg Asn Val Asn Phe G1n Lys Ala Ile Asn675 680 685G1u Lys Leu Gly Gln Tyr Ala Ser Pro Thr Ala Lys Arg Cys Cys Gln690 695 700Asp Gly Val Thr Arg Leu pro Met Met Arg Ser Cys G1u Gln Arg Ala705 710 715 720Ala Arg Val G1n Gln Pro Asp Cys Arg Glu pro Phe Leu Ser Cys Cys725 730 735Gln Phe Ala Glu Ser Leu Arg Lys Lys Ser Arg Asp Lys Gly Gln Ala
740 745 750Gly Leu Gln Arg Ala Leu Glu Ile Leu Gln Glu Glu Asp Leu Ile Asp755 760 765Glu Asp Asp Ile Pro Val Arg Ser Phe Phe Pro Glu Asn Trp Leu Trp770 775 780Arg Val Glu Thr Val Asp Arg Phe Gln Ile Leu Thr Leu Trp Leu Pro785 790 795 800Asp Ser Leu Thr Thr Trp Glu Ile His Gly Leu Ser Leu Ser Lys Thr805 810 815Lys Gly Leu Cys Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu820 825 830Phe His Leu His Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln835 840 845Leu Glu Leu Arg Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr850 855 860Val Ser Val His Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly Gly865 870 875 880Gly Gly Leu Ala Gln Gln Val Leu Val Pro Ala Gly Ser Ala Arg Pro885 890 895Val Ala Phe Ser Val Val Pro Thr Ala Ala Ala Ala Val Ser Leu Lys900 905 910Val Val Ala Arg Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser915 920 925Lys Val Leu Gln Ile Glu Lys Glu Gly Ala Ile His Arg Glu Glu Leu
930 935 940Val Tyr Glu Leu Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile945 950 955 960Pro Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser965 970 975Tyr Val Arg Val Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu980 985 990Gly Ala Leu Ser Pro Gly Gly Val Ala Ser Leu Leu Arg Leu Pro Arg995 10001005Gly Cys Gly Glu Gln Thr Met Ile Tyr Leu Ala Pro Thr Leu Ala101010151020Ala Ser Arg Tyr Leu Asp Lys Thr Glu Gln Trp Ser Thr Leu Pro102510301035Pro Glu Thr Lys Asp His Ala Val Asp Leu Ile Gln Lys Gly Tyr104010451050Met Arg Ile Gln Gln Phe Arg Lys Ala Asp Gly Ser Tyr Ala Ala105510601065Trp Leu Ser Arg Asp Ser Ser Thr Trp Leu Thr Ala Phe Val Leu107010751080Lys Val Leu Ser Leu Ala Gln Glu Gln Val Gly Gly Ser Pro Glu108510901095Lys Leu Gln Glu Thr Ser Asn Trp Leu Leu Ser Gln Gln Gln Ala1100 11051110Asp Gly Ser Phe Gln Asp Pro Cys Pro Val Leu Asp Arg Ser Met
111511201125Gln Gly Gly Leu Val Gly Asn Asp Glu Thr Val Ala Leu Thr Ala113011351140Phe Val Thr Ile Ala Leu His His Gly Leu Ala Val Phe Gln Asp114511501155Glu Gly Ala Glu Pro Leu Lys Gln Arg Val Glu Ala Ser Ile Ser116011651170Lys Ala Asn Ser Phe Leu Gly Glu Lys Ala Ser Ala Gly Leu Leu117511801185Gly Ala His Ala Ala Ala Ile Thr Ala Tyr Ala Leu Ser Leu Thr119011951200Lys Ala Pro Val Asp Leu Leu Gly Val Ala His Asn Asn Leu Met120512101215Ala Met Ala Gln Glu Thr Gly Asp Asn Leu Tyr Trp Gly Ser Val122012251230Thr Gly Ser Gln Ser Asn Ala Val Ser Pro Thr Pro Ala Pro Arg123512401245Asn Pro Ser Asp Pro Met Pro Gln Ala Pro Ala Leu Trp Ile Glu125012551260Thr Thr Ala Tyr Ala Leu Leu His Leu Leu Leu His Glu Gly Lys126512701275Ala Glu Met Ala Asp Gln Ala Ser Ala Trp Leu Thr Arg Gln Gly128012851290Ser Phe Gln Gly Gly Phe Arg Ser Thr Gln Asp Thr Val Ile Ala
129513001305Leu Asp Ala Leu Ser Ala Tyr Trp Ile Ala Ser His Thr Thr Glu131013151320Glu Arg Gly Leu Asn Val Thr Leu Ser Ser Thr Gly Arg Asn Gly132513301335Phe Lys Ser His Ala Leu Gln Leu Asn Asn Arg Gln Ile Arg Gly134013451350Leu Glu Glu Glu Leu Gln Phe Ser Leu Gly Ser Lys Ile Asn Val135513601365Lys Val Gly Gly Asn Ser Lys Gly Thr Leu Lys Val Leu Arg Thr137013751380Tyr Asn Val Leu Asp Met Lys Asn Thr Thr Cys Gln Asp Leu Gln138513901395Ile Glu Val Thr Val Lys Gly His Val Glu Tyr Thr Met Glu Ala140014051410Asn Glu Asp Tyr Glu Tyr Asp Glu Leu Pro Ala Lys Asp Asp Pro141514201425Asp Ala Pro Leu Gln Pro Val Thr Pro Leu Gln Leu Phe Glu Gly143014351440Arg Arg Asn Arg Arg Arg Arg Glu Ala Pro Lys Val Val Glu Glu144514501455Gln Glu Ser Arg Val His Tyr Thr Val Cys Ile Trp Arg Asn Gly146014651470Lys Val Gly Leu Ser Gly Met Ala Ile Ala Asp Val Thr Leu Leu
147514801485Ser Gly Phe His Ala Leu Arg Ala Asp Leu Glu Lys Leu Thr Ser149014951500Leu Ser Asp Arg Tyr Val Ser His Phe Glu Thr Glu Gly Pro His150515101515Val Leu Leu Tyr Phe Asp Ser Val Pro Thr Ser Arg Glu Cys Val152015251530Gly Phe Glu Ala Val Gln Glu Val Pro Val Gly Leu Val Gln Pro153515401545Ala Ser Ala Thr Leu Tyr Asp Tyr Tyr Asn Pro Glu Arg Arg Cys155015551560Ser Val Phe Tyr Gly Ala Pro Ser Lys Ser Arg Leu Leu Ala Thr156515701575Leu Cys Ser Ala Glu Val Cys Gln Cys Ala Glu Gly Lys Cys Pro158015851590Arg Gln Arg Arg Ala Leu Glu Arg Gly Leu Gln Asp Glu Asp Gly159516001605Tyr Arg Met Lys Phe Ala Cys Tyr Tyr Pro Arg Val Glu Tyr Gly161016151620Phe Gln Val Lys Val Leu Arg Glu Asp Ser Arg Ala Ala Phe Arg162516301635Leu Phe Glu Thr Lys Ile Thr Gln Val Leu His Phe Thr Lys Asp164016451650Val Lys Ala Ala Ala Asn Gln Met Arg Asn Phe Leu Val Arg Ala
165516601665Ser Cys Arg Leu Arg Leu Glu Pro Gly Lys Glu Tyr Leu Ile Met167016751680Gly Leu Asp Gly Ala Thr Tyr Asp Leu Glu Gly His Pro Gln Tyr168516901695Leu Leu Asp Ser Asn Ser Trp Ile Glu Glu Met Pro Ser Glu Arg170017051710Leu Cys Arg Ser Thr Arg Gln Arg Ala Ala Cys Ala Gln Leu Asn171517201725Asp Phe Leu Gln Glu Tyr Gly Thr Gln Gly Cys Gln Val173017351740<210>5<211>3890<212>DNA<213>ÈË<220>
<221>²¹Ìå³É·Ö7<222>(1)..(3890)<223>J03507<400>5atgaaggtga taagcttatt cattttggtg ggatttatag gagagttcca aagtttttca 60
agtgcctcct ctccagtcaa ctgccagtgg gacttctatg ccccttggtc agaatgcaat 120ggctgtacca agactcagac tcgcaggcgg tcagttgctg tgtatgggca gtatggaggc 180cagccttgtg ttggaaatgc ttttgaaaca cagtcctgtg aacctacaag aggatgtcca 240acagaggagg gatgtggaga gcgtttcagg tgcttttcag gtcagtgcat cagcaaatca 300ttggtttgca atggggattc tgactgtgat gaagacagtg ctgatgaaga cagatgtgag 360gactcagaaa ggagaccttc ctgtgatatc gataaacctc ctcctaacat agaacttact 420ggaaatggtt acaatgaact cactggccag tttaggaaca gagtcatcaa taccaaaagt 480tttggtggtc aatgtagaaa ggtgtttagt ggggatggaa aagatttcta caggctgagt 540ggaaatgtcc tgtcctatac attccaggtg aaaataaata atgattttaa ttatgaattt 600tacaatagta cttggtctta tgtaaaacat acgtcgacag aacacacatc atctagtcgg 660aagcgctcct tttttagatc ttcatcatct tcttcacgca gttatacttc acataccaat 720gaaatccata aaggaaagag ttaccaactg ctggttgttg agaacactgt tgaagtggct 780cagttcatta ataacaatcc agaattttta caacttgctg agccattctg gaaggagctt 840tcccacctcc cctctctgta tgactacagt gcctaccgaa gattaatcga ccagtacggg 900acacattatc tgcaatctgg gtcgttagga ggagaataca gagttctatt ttatgtggac 960tcagaaaaat taaaacaaaa tgattttaat tcagtcgaag aaaagaaatg taaatcctca1020ggttggcatt ttgtcgttaa attttcaagt catggatgca aggaactgga aaacgcttta1080aaagctgctt caggaaccca gaacaatgta ttgcgaggag aaccgttcat cagaggggga1140ggtgcaggct tcatatctgg ccttagttac ctagagctgg acaatcctgc tggaaacaaa1200aggcgatatt ctgcctgggc agaatctgtg actaatcttc ctcaagtcat aaaacaaaag1260ctgacacctt tatatgagct ggtaaaggaa gtaccttgtg cctctgtgaa aaaactatac1320ctgaaatggg ctcttgaaga gtatctggat gaatttgacc cctgtcattg ccggccttgt1380caaaatggtg gtttggctac tgttgagggg acccattgtc tgtgccattg caaaccgtac1440acatttggtg cggcgtgtga gcaaggagtc ctcgtaggga atcaagcagg aggggttgat1500
ggaggttgga gttgctggtc ctcttggagc ccctgtgtcc aagggaagaa aacaagaagc 1560cgtgaatgca ataacccacc tcccagtggg ggtgggagat cctgcgttgg agaaacgaca 1620gaaagcacac aatgcgaaga tgaggagctg gagcacttga ggttgcttga accacattgc 1680tttcctttgt ctttggttcc aacagaattc tgtccatcac ctcctgcctt gaaagatgga 1740tttgttcaag atgaaggtcc aatgtttcct gtggggaaaa atgtagtgta cacttgcaat 1800gaaggatact ctcttattgg aaacccagtg gccagatgtg gagaagattt acggtggctt 1860gttggggaaa tgcattgtca gaaaattgcc tgtgttctac ctgtactgat ggatggcata 1920cagagtcacc cccaaaaacc tttctacaca gttggtgaga aggtgactgt ttcctgttca 1980ggtggcatgt ccttagaagg tccttcagca tttctctgtg gctccagcct taagtggagt 2040cctgagatga agaatgcccg ctgtgtacaa aaagaaaatc cgttaacaca ggcagtgcct 2100aaatgtcagc gctgggagaa actgcagaat tcaagatgtg tttgtaaaat gccctacgaa 2160tgtggacctt ccttggatgt atgtgctcaa gatgagagaa gcaaaaggat actgcctctg 2220acagtttgca agatgcatgt tctccactgt cagggtagaa attacaccct tactggtagg 2280gacagctgta ctctgcctgc ctcagctgag aaagcttgtg gtgcctgccc actgtgggga 2340aaatgtgatg ctgagagcag caaatgtgtc tgccgagaag catcggagtg cgaggaagaa 2400gggtttagca tttgtgtgga agtgaacggc aaggagcaga cgatgtctga gtgtgaggcg 2460ggcgctctga gatgcagagg gcagagcatc tctgtcacca gcataaggcc ttgtgctgcg 2520gaaacccagt aggctcctgg aggccatggt cagcttgctt ggaatccagc aggcagctgg 2580ggctgagtga aaacatctgc acaactgggc actggacagc ttttccttct tctccagtgt 2640ctaccttcct cctcaactcc cagccatctg tataaacaca atcctttgtt ctcccaaatc 2700tgaatcgaat tactcttttg cctccttttt aatgtcagta aggatatgag cctttgcaca 2760ggctggctgc gtgttcttga aataggtgtt accttctctg ggccttggtt ttttaaaatc 2820tgtaaaatta gaggattgca ctagagaaac ttgaatgctc cattcaggcc tatcatttta 2880ttaagtatga ttgacacagc ccatgggcca gaacacactc tacaaaatga ctaggataac 2940
agaaagaacg tgatctcctg attagagagg gtggttttcc tcaatggaac caaatataaa3000gaggacttga acaaaaatga cagatacaaa ctatttctat cctgagtagt aatctcacac3060ttcatcctat agagtcaacc accacagata ggaattcctt attctttttt taattttttt3120aagacagagt ctcactttgt tgcccaggct ggagcgcagt ggggtgatct catctccctg3180caacctccgc ctcctgggtt gaagcgattc ttgtgcctca gcttcccaag cagctgggat3240tacaggtgcc cgccaccacg cccagctaat ttttgcattt ttagtagaga tgggtttcac3300catgttggcc atgctcgtct ccaactcctg acctcaggta atccgtctgc cttggcctcc3360caaatgctgg gattacagac atgaaccacc acgcctggct ggaatactta ctcttgtcgg3420gagattgaac cactaaaatg ttagagcaga attcattatg ctgtggtcac aggggtgtct3480tgtctgagaa caaatacaat tcagtcttct ctttggggtt ttagtatgtg tcaaacatag3540gactggaagt ttgcccctgt tcttttttct tttgaaagaa catcagttca tgcctgaggc3600atgagtgact gtgcatttga gatagttttc cctattctgt ggatacagtc ccagagtttt3660cagggagtac acaggtagat tagtttgaag cattgacctt ttatttattc cttatttctc3720tttcatcaaa acaaaacagc agctgtggga ggagaaatga gagggcttaa atgaaattta3780aaataagcta tattatacaa atactatctc tgtattgttc tgaccctggt aaatatattt3840caaaacttca gatgacaagg attagaacac tcattaagat gctattcttc 3890<210>6<211>843<212>PRT<213>ÈË<220>
<221>²¹Ìå³É·Ö7
<222>(1)..(843)<223> NP000578<400>6Met Lys Val Ile Ser Leu Phe Ile Leu Val Gly Phe Ile Gly Glu Phe1 5 10 15Gln Ser Phe Ser Ser Ala Ser Ser Pro Val Asn Cys Gln Trp Asp Phe20 25 30Tyr Ala Pro Trp Ser Glu Cys Asn Gly Cys Thr Lys Thr Gln Thr Arg35 40 45Arg Arg Ser Val Ala Val Tyr Gly Gln Tyr Gly Gly Gln Pro Cys Val50 55 60Gly Asn Ala Phe Glu Thr Gln Ser Cys Glu Pro Thr Arg Gly Cys Pro65 70 75 80Thr Glu Glu Gly Cys Gly Glu Arg Phe Arg Cys Phe Ser Gly Gln Cys85 90 95Ile Ser Lys Ser Leu Val Cys Asn Gly Asp Ser Asp Cys Asp Glu Asp100 105 110Ser Ala Asp Glu Asp Arg Cys Glu Asp Ser Glu Arg Arg Pro Ser Cys115 120 125Asp Ile Asp Lys Pro Pro Pro Asn Ile Glu Leu Thr Gly Asn Gly Tyr130 135 140Asn Glu Leu Thr Gly Gln Phe Arg Asn Arg Val Ile Asn Thr Lys Ser145 150 155 160
Phe Gly Gly Gln Cys Arg Lys Val Phe Ser Gly Asp Gly Lys Asp Phe165 170 175Tyr Arg Leu Ser Gly Asn Val Leu Ser Tyr Thr Phe Gln Val Lys Ile180 185 190Asn Asn Asp Phe Asn Tyr Glu Phe Tyr Asn Ser Thr Trp Ser Tyr Val195 200 205Lys His Thr Ser Thr Glu His Thr Ser Ser Ser Arg Lys Arg Ser Phe210 215 220Phe Arg Ser Ser Ser Ser Ser Ser Arg Ser Tyr Thr Ser His Thr Asn225 230 235 240Glu Ile His Lys Gly Lys Ser Tyr Gln Leu Leu Val Val Glu Asn Thr245 250 255Val Glu Val Ala Gln Phe Ile Asn Asn Asn Pro Glu Phe Leu Gln Leu260 265 270Ala Glu Pro Phe Trp Lys Glu Leu Ser His Leu Pro Ser Leu Tyr Asp275 280 285Tyr Ser Ala Tyr Arg Arg Leu Ile Asp Gln Tyr Gly Thr His Tyr Leu290 295 300Gln Ser Gly Ser Leu Gly Gly Glu Tyr Arg Val Leu Phe Tyr Val Asp305 310 315 320Ser Glu Lys Leu Lys Gln Asn Asp Phe Asn Ser Val Glu Glu Lys Lys325 330 335Cys Lys Ser Ser Gly Trp His Phe Val Val Lys Phe Ser Ser His Gly340 345 350
Cys Lys Glu Leu Glu Asn Ala Leu Lys Ala Ala Ser Gly Thr Gln Asn355 360 365Asn Val Leu Arg Gly Glu Pro Phe Ile Arg Gly Gly Gly Ala Gly Phe370 375 380Ile Ser Gly Leu Ser Tyr Leu Glu Leu Asp Asn Pro Ala Gly Asn Lys385 390 395 400Arg Arg Tyr Ser Ala Trp Ala Glu Ser Val Thr Asn Leu Pro Gln Val405 410 415Ile Lys Gln Lys Leu Thr Pro Leu Tyr Glu Leu Val Lys Glu Val Pro420 425 430Cys Ala Ser Val Lys Lys Leu Tyr Leu Lys Trp Ala Leu Glu Glu Tyr435 440 445Leu Asp Glu Phe Asp Pro Cys His Cys Arg Pro Cys Gln Asn Gly Gly450 455 460Leu Ala Thr Val Glu Gly Thr His Cys Leu Cys His Cys Lys Pro Tyr465 470 475 480Thr Phe Gly Ala Ala Cys Glu Gln Gly Val Leu Val Gly Asn Gln Ala485 490 495Gly Gly Val Asp Gly Gly Trp Ser Cys Trp Ser Ser Trp Ser Pro Cys500 505 510Val Gln Gly Lys Lys Thr Arg Ser Arg Glu Cys Asn Asn Pro Pro Pro515 520 525Ser Gly Gly Gly Arg Ser Cys Val Gly Glu Thr Thr Glu Ser Thr Gln530 535 540
Cys Glu Asp Glu Glu Leu Glu His Leu Arg Leu Leu Glu Pro His Cys545 550 555 560Phe Pro Leu Ser Leu Val Pro Thr Glu Phe Cys Pro Ser Pro Pro Ala565 570 575Leu Lys Asp Gly Phe Val Gln Asp Glu Gly Thr Met Phe Pro Val Gly580 585 590Lys Asn Val Val Tyr Thr Cys Asn Glu Gly Tyr Ser Leu Ile Gly Asn595 600 605Pro Val Ala Arg Cys Gly Glu Asp Leu Arg Trp Leu Val Gly Glu Met610 615 620His Cys Gln Lys Ile Ala Cys Val Leu Pro Val Leu Met Asp Gly Ile625 630 635 640Gln Ser His Pro Gln Lys Pro Phe Tyr Thr Val Gly Glu Lys Val Thr645 650 655Val Ser Cys Ser Gly Gly Met Ser Leu Glu Gly Pro Ser Ala Phe Leu660 665 670Cys Gly Ser Ser Leu Lys Trp Ser Pro Glu Met Lys Asn Ala Arg Cys675 680 685Val Gln Lys Glu Asn Pro Leu Thr Gln Ala Val Pro Lys Cys Gln Arg690 695 700Trp Glu Lys Leu Gln Asn Ser Arg Cys Val Cys Lys Met Pro Tyr Glu705 710 715 720Cys Gly Pro Ser Leu Asp Val Cys Ala Gln Asp Glu Arg Ser Lys Arg725 730 735
Ile Leu Pro Leu Thr Val Cys Lys Met His Val Leu His Cys Gln Gly740 745 750Arg Asn Tyr Thr Leu Thr Gly Arg Asp Ser Cys Thr Leu Pro Ala Ser755 760 765Ala Glu Lys Ala Cys Gly Ala Cys Pro Leu Trp Gly Lys Cys Asp Ala770 775 780Glu Ser Ser Lys Cys Val Cys Arg Glu Ala Ser Glu Cys Glu Glu Glu785 790 795 800Gly Phe Ser Ile Cys Val Glu Val Asn Gly Lys Glu Gln Thr Met Ser805 810 815Glu Cys Glu Ala Gly Ala Leu Arg Cys Arg Gly Gln Ser Ile Ser Val820 825 830Thr Ser Ile Arg Pro Cys Ala Ala Glu Thr Gln835 840<210>7<211>1420<212>DNA<213>ÈË<220>
<221>³ÉÏËάϸ°ûÉú³¤Òò×Ó9<222>(1)..(1420)<223>D14838
<400>7tgaaacagca gattactttt atttatgcat ttaatggatt gaagaaaaga accttttttt 60ttctctctct ctctgcaact gcagtaaggg aggggagttg gatatacctc gcctaatatc120tcctgggttg acaccatcat tattgtttat tcttgtgctc caaaagccga gtcctctgat180ggctccctta ggtgaagttg ggaactattt cggtgtgcag gatgcggtac cgtttgggaa240tgtgcccgtg ttgccggtgg acagcccggt tttgttaagt gaccacctgg gtcagtccga300agcagggggg ctccccaggg gacccgcagt cacggacttg gatcatttaa aggggattct360caggcggagg cagctatact gcaggactgg atttcactta gaaatcttcc ccaatggtac420tatccaggga accaggaaag accacagccg atttggcatt ctggaattta tcagtatagc480agtgggcctg gtcagcattc gaggcgtgga cagtggactc tacctcggga tgaatgagaa540gggggagctg tatggatcag aaaaactaac ccaagagtgt gtattcagag aacagttcga600agaaaactgg tataatacgt actcgtcaaa cctatataag cacgtggaca ctggaaggcg660atactatgtt gcattaaata aagatgggac cccgagagaa gggactagga ctaaacggca720ccagaaattc acacattttt tacctagacc agtggacccc gacaaagtac ctgaactgta780taaggatatt ctaagccaaa gttgacaaag acaatttctt cacttgagcc cttaaaaaag840taaccactat aaaggtttca cgcggtgggt tcttattgat tcgctgtgtc atcacatcag900ctccactgtt gccaaacttt gtcgcatgca taatgtatga tggaggcttg gatgggaata960tgctgatttt gttctgcact taaaggcttc tcctcctgga gggctgccta gggccacttg 1020cttgatttat catgagagaa gaggagagag agagagactg agcgctagga gtgtgtgtat 1080gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt atgtgtgtag cgggagatgt gggcggagcg 1140agagcaaaag gactgcggcc tgatgcatgc tggaaaaaag acacgctttt catttctgat 1200cagttgtact tcatcctata tcagcacagc tgccatactt cgacttatca ggattctggc 1260tggtggcctg cgcgagggtg cagtcttact taaaagactt tcagttaatt ctcactggta 1320
tcatcgcagt gaacttaaag caaagacctc ttagtaaaaa ataaaaaaaa ataaaaaata 1380aaaataaaaa aagttaaatt tatttataga aattccaaaa1420<210>8<211>208<212>PRT<213>ÈË<220>
<22l>³ÉÏËάϸ°ûÉú³¤Òò×Ó9<222>(1)..(208)<223>NP002001<400>8Met Ala Pro Leu Gly Glu Val Gly Asn Tyr Phe Gly Val Gln Asp Ala1 5 10 15Val Pro Phe Gly Asn Val Pro Val Leu Pro Val Asp Ser Pro Val Leu20 25 30Leu Ser Asp His Leu Gly Gln Ser Glu Ala Gly Gly Leu Pro Arg Gly35 40 45Pro Ala Val Thr Asp Leu Asp His Leu Lys Gly Ile Leu Arg Arg Arg50 55 60Gln Leu Tyr Cys Arg Thr Gly Phe His Leu Glu Ile Phe Pro Asn Gly65 70 75 80
Thr Ile Gln Gly Thr Arg Lys Asp His Ser Arg Phe Gly Ile Leu Glu85 90 95Phe Ile Ser Ile Ala Val Gly Leu Val Ser Ile Arg Gly Val Asp Ser100 105 110Gly Leu Tyr Leu Gly Met Asn Glu Lys Gly Glu Leu Tyr Gly Ser Glu115 120 125Lys Leu Thr Gln Glu Cys Val Phe Arg Glu Gln Phe Glu Glu Asn Trp130 135 140Tyr Asn Thr Tyr Ser Ser Asn Leu Tyr Lys His Val Asp Thr Gly Arg145 150 155 160Arg Tyr Tyr Val Ala Leu Asn Lys Asp Gly Thr Pro Arg Glu Gly Thr165 170 175Arg Thr Lys Arg His Gln Lys Phe Thr His Phe Leu Pro Arg Pro Val180 185 190Asp Pro Asp Lys Val Pro Glu Leu Tyr Lys Asp Ile Leu Ser Gln Ser195 200 205<210>9<211>4049<212>DNA<213>ÈË<220>
<221>Gremlin
<222>(1)..(4049)<223>AFl10137<400>9gcggccgcac tcagcgccac gcgtcgaaag cgcaggcccc gaggacccgc cgcactgaca 60gtatgagccg cacagcctac acggtgggag ccctgcttct cctcttgggg accctgctgc 120cggctgctga agggaaaaag aaagggtccc aaggtgccat ccccccgcca gacaaggccc 180agcacaatga ctcagagcag actcagtcgc cccagcagcc tggctccagg aaccgggggc 240ggggccaagg gcggggcact gccatgcccg gggaggaggt gctggagtcc agccaagagg 300ccctgcatgt gacggagcgc aaatacctga agcgagactg gtgcaaaacc cagccgctta 360agcagaccat ccacgaggaa ggctgcaaca gtcgcaccat catcaaccgc ttctgttacg 420gccagtgcaa ctctttctac atccccaggc acatccggaa ggaggaaggt tcctttcagt 480cctgctcctt ctgcaagccc aagaaattca ctaccatgat ggtcacactc aactgccctg 540aactacagcc acctaccaag aagaagagag tcacacgtgt gaagcagtgt cgttgcatat 600ccatcgattt ggattaagcc aaatccaggt gcacccagca tgtcctagga atgcagcccc 660aggaagtccc agacctaaaa caaccagatt cttacttggc ttaaacctag aggccagaag 720aacccccagc tgcctcctgg caggagcctg cttgtgcgta gttcgtgtgc atgagtgtgg 780atgggtgcct gtgggtgttt ttagacacca gagaaaacac agtctctgct agagagcact 840ccctattttg taaacatatc tgctttaatg gggatgtacc agaaacccac ctcaccccgg 900ctcacatcta aaggggcggg gccgtggtct ggttctgact ttgtgttttt gtgccctcct 960ggggaccaga atctcctttc ggaatgaatg ttcatggaag aggctcctct gagggcaaga1020gacctgtttt agtgctgcat tcgacatgga aaagtccttt taacctgtgc ttgcatcctc1080ctttcctcct cctcctcaca atccatctct tcttaagttg atagtgacta tgtcagtcta1140atctcttgtt tgccaaggtt cctaaattaa ttcacttaac catgatgcaa atgtttttca1200
ttttgtgaag accctccaga ctctgggaga ggctggtgtg ggcaaggaca agcaggatag1260tggagtgaga aagggagggt ggagggtgag gccaaatcag gtccagcaaa agtcagtagg1320gacattgcag aagcttgaaa ggccaatacc agaacacagg ctgatgcttc tgagaaagtc1380ttttcctagt atttaacaga acccaagtga acagaggaga aatgagattg ccagaaagtg1440attaactttg gccgttgcaa tctgctcaaa cctaacacca aactgaaaac ataaatactg1500accactccta tgttcggacc caagcaagtt agctaaacca aaccaactcc tctgctttgt1560ccctcaggtg gaaaagagag gtagtttaga actctctgca taggggtggg aattaatcaa1620aaacckcaga ggctgaaatt cctaatacct ttcctttatc gtggttatag tcagctcatt1680tccattccac tatttcccat aatgcttctg agagccacta acttgattga taaagatcct1740gcctctgctg agtgtacctg acagtaagtc taaagatgar agagtttagg gactactctg1800ttttagcaag aratattktg ggggtctttt tgttttaact attgtcagga gattgggcta1860ragagaagac gacgagagta aggaaataaa gggrattgcc tctggctaga gagtaagtta1920ggtgttaata cctggtagaa atgtaaggga tatgacctcc ctttctttat gtgctcactg1980aggatctgag gggaccctgt taggagagca tagcatcatg atgtattagc tgttcatctg2040ctactggttg gatggacata actattgtaa ctattcagta tttactggta ggcactgtcc2100tctgattaaa cttggcctac tggcaatggc tacttaggat tgatctaagg gccaaagtgc2160agggtgggtg aactttattg tactttggat ttggttaacc tgttttcttc aagcctgagg2220ttttatatac aaactccctg aatactcttt ttgccttgta tcttctcagc ctcctagcca2280agtcctatgt aatatggaaa acaaacactg cagacttgag attcagttgc cgatcaaggc2340tctggcattc agagaaccct tgcaactcga gaagctgttt ttatttcgtt tttgttttga2400tccagtgctc tcccatctaa caactaaaca ggagccattt caaggcggga gatattttaa2460acacccaaaa tgttgggtct gattttcaaa cttttaaact cactactgat gattctcacg2520ctaggcgaat ttgtccaaac acatagtgtg tgtgttttgt atacactgta tgaccccacc2580ccaaatcttt gtattgtcca cattctccaa caataaagca cagagtggat ttaattaagc2640
acacaaatgc taaggcagaa ttttgagggt gggagagaag aaaagggaaa gaagctgaaa2700atgtaaaacc acaccaggga ggaaaaatga cattcagaac cagcaaacac tgaatttctc2760ttgttgtttt aactctgcca caagaatgca atttcgttaa tggagatgac ttaagttggc2820agcagtaatc ttcttttagg agcttgtacc acagtcttgc acataagtgc agatttggct2880caagtaaaga gaatttcctc aacactaact tcactgggat aatcagcagc gtaactaccc2940taaaagcata tcactagcca aagagggaaa tatctgttct tcttactgtg cctatattaa3000gactagtaca aatgtggtgt gtcttccaac tttcattgaa aatgccatat ctataccata3060ttttattcga gtcactgatg atgtaatgat atattttttc attattatag tagaatattt3120ttatggcaag atatttgtgg tcttgatcat acctattaaa ataatgccaa acaccaaata3180tgaattttat gatgtacact ttgtgcttgg cattaaaaga aaaaaacaca catcctggaa3240gtctgtaagt tgttttttgt tactgtaggt cttcaaagtt aagagtgtaa gtgaaaaatc3300tggaggagag gataatttcc actgtgtgga atgtgaatag ttaaatgaaa agttatggtt3360atttaatgta attattactt caaatccttt ggtcactgtg atttcaagca tgttttcttt3420ttctccttta tatgactttc tctgagttgg gcaaagaaga agctgacaca ccgtatgttg3480ttagagtctt ttatctggtc aggggaaaca aaatcttgac ccagctgaac atgtcttcct3540gagtcagtgc ctgaatcttt attttttaaa ttgaatgttc cttaaaggtt aacatttcta3600aagcaatatt aagaaagact ttaaatgtta ttttggaaga cttacgatgc atgtatacaa3660acgaatagca gataatgatg actagttcac acataaagtc cttttaagga gaaaatctaa3720aatgaaaagt ggataaacag aacatttata agtgatcagt taatgcctaa gagtgaaagt3780agttctattg acattcctca agatatttaa tatcaactgc attatgtatt atgtctgctt3840aaatcattta aaaacggcaa agaattatat agactatgag gtaccttgct gtgtaggagg3900atgaaagggg agttgatagt ctcataaaac taatttggct tcaagtttca tgaatctgta3960actagaattt aattttcacc ccaataatgt tctatatagc ctttgctaaa gagcaactaa4020taaattaaac ctattctttc aaaaaaaaa 4049
<210>10<211>184<212>PRT<213>ÈË<220>
<221>Gremlin<222>(1)..(184)<223>NP037504<400>10Met Ser Arg Thr Ala Tyr Thr Val Gly Ala Leu Leu Leu Leu Leu Gly1 5 10 15Thr Leu Leu Pro Ala Ala Glu Gly Lys Lys Lys Gly Ser Gln Gly Ala20 25 30Ile Pro Pro Pro Asp Lys Ala Gln His Asn Asp Ser Glu Gln Thr Gln35 40 45Ser Pro Gln Gln Pro Gly Ser Arg Asn Arg Gly Arg Gly Gln Gly Arg50 55 60Gly Thr Ala Met Pro Gly Glu Glu Val Leu Glu Ser Ser Gln Glu Ala65 70 75 80Leu His Val Thr Glu Arg Lys Tyr Leu Lys Arg Asp Trp Cys Lys Thr85 90 95
Gln Pro Leu Lys Gln Thr Ile His Glu Glu Gly Cys Asn Ser Arg Thr100 105 110Ile Ile Asn Arg Phe Cys Tyr Gly Gln Cys Asn Ser Phe Tyr Ile Pro115 120 125Arg His Ile Arg Lys Glu Glu Gly Ser Phe Gln Ser Cys Ser Phe Cys130 135 140Lys Pro Lys Lys Phe Thr Thr Met Met Val Thr Leu Asn Cys Pro Glu145 150 155 160Leu Gln Pro Pro Thr Lys Lys Lys Arg Val Thr Arg Val Lys Gln Cys165 170 175Arg Cys Ile Ser Ile Asp Leu Asp180<210>11<211>1146<212>DNA<213>ÈË<220>
<221>Intelectin<222>(1)..(1146)<223>AK000029<400>11
agggagggag tgaaggagct ctctgtaccc aaggaaagtg cagctgagac tcagacaaga 60ttacaatgaa ccaactcagc ttcctgctgt ttctcatagc gaccaccaga ggatggagta 120cagatgaggc taatacttac ttcaaggaat ggacctgttc ttcgtctcca tctctgccca 180gaagctgcaa ggaaatcaaa gacgaatgtc ctagtgcatt tgatggcctg tattttctcc 240gcactgagaa tggtgttatc taccagacct tctgtgacat gacctctggg ggtggcggct 300ggaccctggt ggccagcgtg catgagaatg acatgcgtgg gaagtgcacg gtgggcgatc 360gctggtccag tcagcagggc agcaaagcag actacccaga gggggacggc aactgggcca 420actacaacac ctttggatct gcagaggcgg ccacgagcga tgactacaag aaccctggct 480actacgacat ccaggccaag gacctgggca tctggcacgt gcccaataag tcccccatgc 540agcactggag aaacagctcc ctgctgaggt accgcacgga cactggcttc ctccagacac 600tgggacataa tctgtttggc atctaccaga aatatccagt gaaatatgga gaaggaaagt 660gttggactga caacggcccg gtgatccctg tggtctatga ttttggcgac gcccagaaaa 720cagcatctta ttactcaccc tatggccagc gggaattcac tgcgggattt gttcagttca 780gggtatttaa taacgagaga gcagccaacg ccttgtgtgc tggaatgagg gtcaccggat 840gtaacactga gcaccactgc attggtggag gaggatactt tccagaggcc agtccccagc 900agtgtggaga tttttctggt tttgattgga gtggatatgg aactcatgtt ggttacagca 960gcagccgtga gataactgag gcagctgtgc ttctattcta tcgttgagag ttttgtggga1020gggaacccag acctctcctc ccaaccatga gatcccaagg atggagaaca acttacccag1080tagctagaat gttaatggca gaagagaaaa caataaatca tattgactca aaaaaaaaaa1140aaaaaa 1146<210>12<211>313
<212>PRT<213>ÈË<220>
<221>Intelectin<222>(1)..(313)<223>NP060095<400>12Met Asn Gln Leu Ser Phe Leu Leu Phe Leu Ile Ala Thr Thr Arg Gly1 5 10 15Trp Ser Thr Asp Glu Ala Asn Thr Tyr Phe Lys Glu Trp Thr Cys Ser20 25 30Ser Ser Pro Ser Leu Pro Arg Ser Cys Lys Glu Ile Lys Asp Glu Cys35 40 45Pro Ser Ala Phe Asp Gly Leu Tyr Phe Leu Arg Thr Glu Asn Gly Val50 55 60Ile Tyr Gln Thr Phe Cys Asp Met Thr Ser Gly Gly Gly Gly Trp Thr65 70 75 80Leu Val Ala Ser Val His Glu Asn Asp Met Arg Gly Lys Cys Thr Val85 90 95Gly Asp Arg Trp Ser Ser Gln Gln Gly Ser Lys Ala Val Tyr Pro Glu100 105 110Gly Asp Gly Asn Trp Ala Asn Tyr Asn Thr Phe Gly Ser Ala Glu Ala115 120 125
Ala Thr Ser Asp Asp Tyr Lys Asn Pro Gly Tyr Tyr Asp Ile Gln Ala130 135 140Lys Asp Leu Gly Ile Trp His Val Pro Asn Lys Ser Pro Met Gln His145 150 155 160Trp Arg Asn Ser Ser Leu Leu Arg Tyr Arg Thr Asp Thr Gly Phe Leu165 170 175Gln Thr Leu Gly His Asn Leu Phe Gly Ile Tyr Gln Lys Tyr Pro Val180 185 190Lys Tyr Gly Glu Gly Lys Cys Trp Thr Asp Asn Gly Pro Val Ile Pro195 200 205Val Val Tyr Asp Phe Gly Asp Ala Gln Lys Thr Ala Ser Tyr Tyr Ser210 215 220Pro Tyr Gly Gln Arg Glu Phe Thr Ala Gly Phe Val Gln Phe Arg Val225 230 235 240Phe Asn Asn Glu Arg Ala Ala Asn Ala Leu Cys Ala Gly Met Arg Val245 250 255Thr Gly Cys Asn Thr Glu His His Cys Ile Gly Gly Gly Gly Tyr Phe260 265 270Pro Glu Ala Ser Pro Gln Gln Cys Gly Asp Phe Ser Gly Phe Asp Trp275 280 285Ser Gly Tyr Gly Thr His Val Gly Tyr Ser Ser Ser Arg Glu Ile Thr290 295 300Glu Ala Ala Val Leu Leu Phe Tyr Arg305 310
<210>13<211>1213<212>DNA<213>ÈË<220>
<221>¼¤ëÄÊÍ·Åø11<222>(1)..(1213)<223>BC022068<400>13agcgtgggag tgcaggcttg gaaagcagga gagctcagcc tacgtcttta atcctcctgc 60ccaccccttg gattctgtct ccactgggac tcaagagagg aacctggggc ccgctcctcc120cccctccagg ccatgaggat tctgcagtta atcctgcttg ctctggcaac agggcttgta180gggggagaga ccaggatcat caaggggttc gagtgcaagc ctcactccca gccctggcag240gcagccctgt tcgagaagac gcggctactc tgtggggcga cgctcatcgc ccccagatgg300ctcctgacag cagcccactg cctcaagccc cgctacatag ttcacctggg gcagcacaac360ctccagaagg aggagggctg tgagcagacc cggacagcca ctgagtcctt cccccacccc420ggcttcaaca acagcctccc caacaaagac caccgcaatg acatcatgct ggtgaagatg480gcatcgccag tctccatcac ctgggctgtg cgacccctca ccctctcctc acgctgtgtc540actgctggca ccagctgcct catttccggc tggggcagca cgtccagccc ccagttacgc600ctgcctcaca ccttgcgatg cgccaacatc accatcattg agcaccagaa gtgtgagaac660gcctaccccg gcaacatcac agacaccatg gtgtgtgcca gcgtgcagga agggggcaag720
gactcctgcc agggtgactc cgggggccct ctggtctgta accagtctct tcaaggcatt780atctcctggg gccaggatcc gtgtgcgatc acccgaaagc ctggtgtcta cacgaaagtc840tgcaaatatg tggactggat ccaggagacg atgaagaaca attagactgg acccacccac900cacagcccat caccctccat ttccacttgg tgtttggttc ctgttcactc tgttaataag960aaaccctaag ccaagaccct ctacgaacat tctttgggcc tcctggacta caggagatgc 1020tgtcacttaa taatcaacct ggggttcgaa atcagtgaga cctggattca aattctgcct 1080tgaaatattg tgactctggg aatgacaaca cctggtttgt tctctgttgt atccccagcc 1140ccaaagacag ctcctggcca tatatcaagg tttcaataaa tatttgctaa atgagtgaaa 1200aaaaaaaaaa aaa 1213<210>14<211>250<212>PRT<213>ÈË<220>
<221>¼¤ëÄÊÍ·Åø11<222>(1)..(250)<223>NP006844<400>14Met Arg Ile Leu Gln Leu Ile Leu Leu Ala Leu Ala Thr Gly Leu Val1 5 10 15Gly Gly Glu Thr Arg Ile Ile Lys Gly Phe Glu Cys Lys Pro His Ser
20 25 30Gln Pro Trp Gln Ala Ala Leu Phe Glu Lys Thr Arg Leu Leu Cys Gly35 40 45Ala Thr Leu Ile Ala Pro Arg Trp Leu Leu Thr Ala Ala His Cys Leu50 55 60Lys Pro Arg Tyr Ile Val His Leu Gly Gln His Asn Leu Gln Lys Glu65 70 75 80Glu Gly Cys Glu Gln Thr Arg Thr Ala Thr Glu Ser Phe Pro His Pro85 90 95Gly Phe Asn Asn Ser Leu Pro Asn Lys Asp His Arg Asn Asp Ile Met100 105 110Leu Val Lys Met Ala Ser Pro Val Ser Ile Thr Trp Ala Val Arg Pro115 120 125Leu Thr Leu Ser Ser Arg Cys Val Thr Ala Gly Thr Ser Cys Leu Ile130 135 140Ser Gly Trp Gly Ser Thr Ser Ser Pro Gln Leu Arg Leu Pro His Thr145 150 155 160Leu Arg Cys Ala Asn Ile Thr Ile Ile Glu His Gln Lys Cys Glu Asn165 170 175Ala Tyr Pro Gly Asn Ile Thr Asp Thr Met Val Cys Ala Ser Val Gln180 185 190Glu Gly Gly Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val195 200 205Cys Asn Gln Ser Leu Gln Gly Ile Ile Ser Trp Gly Gln Asp Pro Cys
210 215 220Ala Ile Thr Arg Lys Pro Gly Val Tyr Thr Lys Val Cys Lys Tyr Val225 230 235 240Asp Trp Ile Gln Glu Thr Met Lys Asn Asn245 250<210>15<211>2114<212>DNA<213>ÈË<220>
<221>Mesothelin(±äÌå2)<222>(1)..(2114)<223>U40434<400>15aggaattccg gtggccggcc actcccgtct gctgtgacgc gcggacagag agctaccggt 60ggacccacgg tgcctccctc cctgggatct acacagacca tggccttgca acggctcgac 120ccctgttggt cctgtgggga ccgccctggc agcctcctgt tcctgctctt cagcctcgga 180tgggtgcatc ccgcgaggac cctggctgga gagacaggga cggagtctgc ccccctgggg 240ggagtcctga caacccccca taacatttcc agcctctccc ctcgccaact ccttggcttc 300ccgtgtgcgg aggtgtccgg cctgagcacg gagcgtgtcc gggagctggc tgtggccttg 360gcacagaaga atgtcaagct ctcaacagag cagctgcgct gtctggctca ccggctctct 420
gagccccccg aggacctgga cgccctccca ttggacctgc tgctattcct caacccagat 480gcgttctcgg ggccccaggc ctgcacccgt ttcttctccc gcatcacgaa ggccaatgtg 540gacctgctcc cgaggggggc tcccgagcga cagcggctgc tgcctgcggc tctggcctgc 600tggggtgtgc gggggtctct gctgagcgag gctgatgtgc gggctctggg aggcctggct 660tgcgacctgc ctgggcgctt tgtggccgag tcggccgaag tgctgctacc ccggctggtg 720agctgcccgg gacccctgga ccaggaccag caggaggcag ccagggcggc tctgcagggc 780gggggacccc cctacggccc cccgtcgaca tggtctgtct ccacgatgga cgctctgcgg 840ggcctgctgc ccgtgctggg ccagcccatc atccgcagca tcccgcaggg catcgtggcc 900gcgtggcggc aacgctcctc tcgggaccca tcctggcggc agcctgaacg gaccatcctc 960cggccgcggt tccggcggga agtggagaag acagcctgtc cttcaggcaa gaaggcccgc1020gagatagacg agagcctcat cttctacaag aagtgggagc tggaagcctg cgtggatgcg1080gccctgctgg ccacccagat ggaccgcgtg aacgccatcc ccttcaccta cgagcagctg1140gacgtcctaa agcataaact ggatgagctc tacccacaag gttaccccga gtctgtgatc1200cagcacctgg gctacctctt cctcaagatg agccctgagg acattcgcaa gtggaatgtg1260acgtccctgg agaccctgaa ggctttgctt gaagtcgaca aagggcacga aatgagtcct1320caggctcctc ggcggcccct cccacaggtg gccaccctga tcgaccgctt tgtgaaggga1380aggggccagc tagacaaaga caccctagac accctgaccg ccttctaccc tgggtacctg1440tgctccctca gccccgagga gctgagctcc gtgcccccca gcagcatctg ggcggtcagg1500ccccaggacc tggacacgtg tgacccaagg cagctggacg tcctctatcc caaggcccgc1560cttgctttcc agaacatgaa cgggtccgaa tacttcgtga agatccagtc cttcctgggt1620ggggccccca cggaggattt gaaggcgctc agtcagcaga atgtgagcat ggacttggcc1680acgttcatga agctgcggac ggatgcggtg ctgccgttga ctgtggctga ggtgcagaaa1740cttctgggac cccacgtgga gggcctgaag gcggaggagc ggcaccgccc ggtgcgggac1800tggatcctac ggcagcggca ggacgacctg gacacgctgg ggctggggct acagggcggc1860
atccccaacg gctacctggt cctagacctc agcgtgcaag agaccctctc ggggacgccc 1920tgcctcctag gacctggacc tgttctcacc gtcctggcac tgctcctagc ctccaccctg 1980gcctgagggc cccactccct tgctggcccc agccctgctg gggatccccg cctggccagg 2040agcaggcacg ggtgatcccc gttccacccc aagagaactc gcgctcagta aacgggaaca 2100tgccccctgc agac 2114<210>16<211>628<212>PRT<213>ÈË<220>
<221>Mesothelin(±äÌå2)<222>(1)..(628)<223>NP037536<400>16Met Ala Leu Gln Arg Leu Asp Pro Cys Trp Ser Cys Gly Asp Arg Pro1 5 10 15Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val His Pro Ala20 25 30Arg Thr Leu Ala Gly Glu Thr Gly Thr Glu Ser Ala Pro Leu Gly Gly35 40 45Val Leu Thr Thr Pro His Asn Ile Ser Ser Leu Ser Pro Arg Gln Leu
50 55 60Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu Arg Val65 70 75 80Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu Ser Thr85 90 95Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro Glu Asp100 105 110Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro Asp Ala115 120 125Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile Thr Lys130 135 140Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln Arg Leu145 150 155 160Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu Leu Ser165 170 175Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu Pro Gly180 185 190Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu Val Ser195 200 205Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg Ala Ala210 215 220Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp Ser Val225 230 235 240Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly Gln Pro
245 250 255Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg Gln Arg260 265 270Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile Leu Arg275 280 285Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser Gly Lys290 295 300Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys Trp Glu305 310 315 320Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met Asp Arg325 330 335Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu Lys His340 345 350Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val Ile Gln355 360 365His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile Arg Lys370 375 380Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu Val Asp385 390 395 400Lys Gly His Glu Met Ser Pro Gln Ala Pro Arg Arg Pro Leu Pro Gln405 410 415Val Ala Thr Leu Ile Asp Arg Phe Val Lys Gly Arg Gly Gln Leu Asp420 425 430Lys Asp Thr Leu Asp Thr Leu Thr Ala Phe Tyr Pro Gly Tyr Leu Cys
435 440 445Ser Leu Ser Pro Glu Glu Leu Ser Ser Val Pro Pro Ser Ser Ile Trp450 455 460Ala Val Arg Pro Gln Asp Leu Asp Thr Cys Asp Pro Arg Gln Leu Asp465 470 475 480Val Leu Tyr Pro Lys Ala Arg Leu Ala Phe Gln Asn Met Asn Gly Ser485 490 495Glu Tyr Phe Val Lys Ile Gln Ser Phe Leu Gly Gly Ala Pro Thr Glu500 505 510Asp Leu Lys Ala Leu Ser Gln Gln Asn Val Ser Met Asp Leu Ala Thr515 520 525Phe Met Lys Leu Arg Thr Asp Ala Val Leu Pro Leu Thr Val Ala Glu530 535 540Val Gln Lys Leu Leu Gly Pro His Val Glu Gly Leu Lys Ala Glu Glu545 550 555 560Arg His Arg Pro Val Arg Asp Trp Ile Leu Arg Gln Arg Gln Asp Asp565 570 575Leu Asp Thr Leu Gly Leu Gly Leu Gln Gly Gly Ile Pro Asn Gly Tyr580 585 590Leu Val Leu Asp Leu Ser Val Gln Glu Thr Leu Ser Gly Thr Pro Cys595 600 605Leu Leu Gly Pro Gly Pro Val Leu Thr Val Leu Ala Leu Leu Leu Ala610 615 620Ser Thr Leu Ala
625<210>17<211>2650<212>DNA<213>ÈË<220>
<221>¶àЧµ°°×<222>(1)..(2650)<223>AB004306<400>17gaattcggca cgagctgcag ggtcaggagg agaatcgtgg ggccaggagg gcagaggcac 60actccatctt cgtgctcctc acaggccctg cctccctgcc tgctaaggac acagggaagg 120gggtccccac ctcagtgcct gcctcccttc cctgtgcctg tgtacctggc agtcacagcc 180acctggcgtg tcccagaaac caaccggctg acctcatctc ctgcccggcc ccacctccat 240tggctttggc ttttggcgtt tgtgctgccc gaccctttct cctgtccgga tgcgcagggc 300agggcctgag ccgtcgagct gcacccacag caggctgcct ttggtgactc accgggtgaa 360cgggggcatt gcgaggcatc ccctccctgg gtttggctcc tgcccacggg gctgacagta 420gaaatcacag gctgtgagac agctggagcc cagctctgct tgaacctatt ttaggtctct 480gatccccgct tcctctttag actcccctag agctcagcca gtgctcaacc tgaggctggg 540ggtctctgag gaagagtgag ttggagctga ggggtctggg gctgtcccct gagagagggg 600ccagaggcag tgtcaagagc cgggcagtct gattgtggct caccctccat cactcccagg 660
gcccctggcc cagcagccgc agctcccaac cacaatatcc tttggggttt ggcctacgga 720gctggggcgg atgaccccca aatagccctg gcagattccc cctagacccg cccgcaccat 780ggtcaggcat gcccctcctc atcgctggca cagcccagag ggtataaaca gtgctggagg 840ctggcggggc aggccagctg agtcctgagc agcagcccag cggatcctga gaacttcagg 900gtgagtttgg ggacccttga ttgttctttc tttttcgcta ttgtaaaatt catgttatat 960ggagggggca aagttttcag ggtgttgttt agaatgggaa gatgtccctt gtatcaccat1020ggaccctcat gataattttg tttctttcac tttctactct gttgacaacc attgtctcct1080cttattttct tttcattttc tgtaactttt tcgttaaact ttagcttgca tttgtaacga1140atttttaaat tcacttttgt ttatttgtca gattgtaagt actttctcta atcacttttt1200tttcaaggca atcagggtat attatattgt acttcagcac agttttagag aacaattgtt1260ataattaaat gataaggtag aatatttctg catataaatt ctggctggcg tggaaatatt1320cttattggta gaaacaacta catcctggtc atcatcctgc ctttctcttt atggttacaa1380tgatatacac tgtttgagat gaggataaaa tactctgagt ccaaaccggg cccctctgct1440aaccatgttc atgccttctt ctttttccta cagctcctgg gcaacgtgct ggttgttgtg1500ctgtctcatc attttggcaa agaattaatt ccaactcaaa aatgcaggct caacagtacc1560agcagcagcg tcgaaaattt gcagctgcct tcttggcatt cattttcata ctggcagctg1620tggatactgc tgaagcaggg aagaaagaga aaccagaaaa aaaagtgaag aagtctgact1680gtggagaatg gcagtggagt gtgtgtgtgc ccaccagtgg agactgtggg ctgggcacac1740gggagggcac tcggactgga gctgagtgca agcaaaccat gaagacccag agatgtaaga1800tcccctgcaa ctggaagaag caatttggcg cggagtgcaa ataccagttc caggcctggg1860gagaatgtga cctgaacaca gccctgaaga ccagaactgg aagtctgaag cgagccctgc1920acaatgccga atgccagaag actgtcacca tctccaagcc ctgtggcaaa ctgaccaagc1980ccaaacctca agcagaatct aagaagaaga aaaaggaagg caagaaacag gagaagatgc2040tggattaaaa gatgtcacct gtggaacata aaaaggacat cagcaaacag gatcaattca2100
ctcctcaggt gcaggctgcc tatcagaagg tggtggctgg tgtggccaat gccctggctc 2160acaaatacca ctgagatctt tttccctctg ccaaaaatta tggggacatc atgaagcccc 2220ttgagcatct gacttctggc taataaagga aatttatttt cattgcaata gtgtgttgga 2280attttttgtg tctctcactc ggaaggacat atgggagggc aaatcattta aaacatcaga 2340atgagtattt ggtttagagt ttggcaacat atgccatatg ctggctgcca tgaacaaagg 2400tggctataaa gaggtcatca gtatatgaaa cagccccctg ctgtccattc cttattccat 2460agaaaagcct tgacttgagg ttagattttt tttatatttt gttttgtgtt atttttttct 2520ttaacatccc taaaattttc cttacatgtt ttactagcca gatttttcct cctctcctga 2580ctactcccag tcatagctgt ccctcttctc ttatggagat ccctcgacct gcaggcaggc 2640atgcaagctt 2650<210>18<211>168<212>PRT<213>ÈË<220>
<221>¶àЧµ°°×<222>(1)..(168)<223>NP002816<400>18Met Gln Ala Gln Gln Tyr Gln Gln Gln Arg Arg Lys Phe Ala Ala Ala1 5 10 15
Phe Leu Ala Phe Ile Phe Ile Leu Ala Ala Val Asp Thr Ala Glu Ala20 25 30Gly Lys Lys Glu Lys Pro Glu Lys Lys Val Lys Lys Ser Asp Cys Gly35 40 45Glu Trp Gln Trp Ser Val Cys Val Pro Thr Ser Gly Asp Cys Gly Leu50 55 60Gly Thr Arg Glu Gly Thr Arg Thr Gly Ala Glu Cys Lys Gln Thr Met65 70 75 80Lys Thr Gln Arg Cys Lys Ile Pro Cys Asn Trp Lys Lys Gln Phe Gly85 90 95Ala Glu Cys Lys Tyr Gln Phe Gln Ala Trp Gly Glu Cys Asp Leu Asn100 105 110Thr Ala Leu Lys Thr Arg Thr Gly Ser Leu Lys Arg Ala Leu His Asn115 120 125Ala Glu Cys Gln Lys Thr Val Thr Ile Ser Lys Pro Cys Gly Lys Leu130 135 140Thr Lys Pro Lys Pro Gln Ala Glu Ser Lys Lys Lys Lys Lys Glu Gly145 150 155 160Lys Lys Gln Glu Lys Met Leu Asp165<210>19<211>852
<212>DNA<213>ÈË<220>
<221>С¿ÉÓÕµ¼Ï¸°ûÒò×ÓÑǼÒ×åA³ÉÔ±21<222>(1)..(852)<223>AB002409<400>19cttgcagctg cccacctcac cctcagctct ggcctcttac tcaccctcta ccacagacat 60ggctcagtca ctggctctga gcctccttat cctggttctg gcctttggca tccccaggac 120ccaaggcagt gatggagggg ctcaggactg ttgcctcaag tacagccaaa ggaagattcc 180cgccaaggtt gtccgcagct accggaagca ggaaccaagc ttaggctgct ccatcccagc 240tatcctgttc ttgccccgca agcgctctca ggcagagcta tgtgcagacc caaaggagct 300ctgggtgcag cagctgatgc agcatctgga caagacacca tccccacaga aaccagccca 360gggctgcagg aaggacaggg gggcctccaa gactggcaag aaaggaaagg gctccaaagg 420ctgcaagagg actgagcggt cacagacccc taaagggcca tagcccagtg agcagcctgg 480agccctggag accccaccag cctcaccaac gcttgaagcc tgaacccaag atgcaagaag 540gaggctatgc tcaggggccc tggagcagcc accccatgct ggccttgcca cactctttct 600cctgctttaa ccaccccatc tgcattccca gctctaccct gcatggctga gctgcccaca 660gcaggccagg tccagagaga ccgaggaggg agagtctccc agggagcatg agaggaggca 720gcaggactgt ccccttgaag gagaatcatc aggaccctgg acctgatacg gctccccagt 780acaccccacc tcttccttgt aaatatgatt tatacctaac tgaataaaaa gctgttctgt 840cttcccaccc gc 852
<210>20<211>134<212>PRT<213>ÈË<220>
<221>С¿ÉÓÕµ¼Ï¸°ûÒò×ÓÑǼÒ×åA³ÉÔ±21<222>(1)..(134)<223>NP002980<400>20Met Ala Gln Ser Leu Ala Leu Ser Leu Leu Ile Leu Val Leu Ala Phe1 5 10 15Gly Ile Pro Arg Thr Gln Gly Ser Asp Gly Gly Ala Gln Asp Cys Cys20 25 30Leu Lys Tyr Ser Gln Arg Lys Ile Pro Ala Lys Val Val Arg Ser Tyr35 40 45Arg Lys Gln Glu Pro Ser Leu Gly Cys Ser Ile Pro Ala Ile Leu Phe50 55 60Leu Pro Arg Lys Arg Ser Gln Ala Glu Leu Cys Ala Asp Pro Lys Glu65 70 75 80Leu Trp Val Gln Gln Leu Met Gln His Leu Asp Lys Thr Pro Ser Pro85 90 95Gln Lys Pro Ala Gln Gly Cys Arg Lys Asp Arg Gly Ala Ser Lys Thr
100 105 110Gly Lys Lys Gly Lys Gly Ser Lys Gly Cys Lys Arg Thr Glu Arg Ser115 120 125Gln Thr Pro Lys Gly Pro130<210>21<211>685<212>DNA<213>ÈË<220>
<221>ÈýÒ¶Òò×Ó3<222>(1)..(685)<223>NM003226<400>21gccaaaacag tgggggctga actgacctct cccctttggg agagaaaaac tgtctgggag 60cttgacaaag gcatgcagga gagaacagga gcagccacag ccaggaggga gagccttccc 120caagcaaaca atccagagca gctgtgcaaa caacggtgca taaatgaggc ctcctggacc 180atgaagcgag tcctgagctg cgtcccggag cccacggtgg tcatggctgc cagagcgctc 240tgcatgctgg ggctggtcct ggccttgctg tcctccagct ctgctgagga gtacgtgggc 300ctgtctgcaa accagtgtgc cgtgccagcc aaggacaggg tggactgcgg ctacccccat 360gtcaccccca aggagtgcaa caaccggggc tgctgctttg actccaggat ccctggagtg 420
ccttggtgtt tcaagcccct gcaggaagca gaatgcacct tctgaggcac ctccagctgc 480ccccggccgg gggatgcgag gctcggagca cccttgcccg gctgtgattg ctgccaggca 540ctgttcatct cagcttttct gtccctttgc tcccggcaag cgcttctgct gaaagttcat 600atctggagcc tgatgtctta acgaataaag gtcccatgct ccacccgagg acagttcttc 660gtgcctgaaa aaaaaaaaaa aaaaa 685<210>22<211>130<212>PRT<213>ÈË<220>
<221>ÈýÒ¶Òò×Ó3<222>(1)..(130)<223>NP003217<400>22Met Gln Glu Arg Thr Gly Ala Ala Thr Ala Arg Arg Glu Ser Leu Pro1 5 10 15Gln Ala Asn Asn Pro Glu Gln Leu Cys Lys Gln Arg Cys Ile Asn Glu20 25 30Ala Ser Trp Thr Met Lys Arg Val Leu Ser Cys Val Pro Glu Pro Thr35 40 45Val Val Met Ala Ala Arg Ala Leu Cys Met Leu Gly Leu Val Leu Ala
50 55 60Leu Leu Ser Ser Ser Ser Ala Glu Glu Tyr Val Gly Leu Ser Ala Asn65 70 75 80Gln Cys Ala Val Pro Ala Lys Asp Arg Val Asp Cys Gly Tyr Pro His85 90 95Val Thr Pro Lys Glu Cys Asn Asn Arg Gly Cys Cys Phe Asp Ser Arg100 105 110Ile Pro Gly Val Pro Trp Cys Phe Lys Pro Leu Gln Glu Ala Glu Cys115 120 125Thr Phe130<210>23<211>1142<212>DNA<213>ÈË<220>
<221>×éÖ¯Òò×Ó;¾¶ÒÖÖÆ¼Á2<222>(1)..(1142)<223>D29992<400>23gccgccagcg gctttctcgg acgccttgcc cagcgggccg cccgaccccc tgcaccatgg60
accccgctcg ccccctgggg ctgtcgattc tgctgctttt cctgacggag gctgcactgg 120gcgatgctgc tcaggagcca acaggaaatc acgcggagat ctgtctcctg cccctagact 180acggaccctg ccgggcccta cttctccgtt actactacga caggtacacg cagagctgcc 240gccagttcct gtacgggggc tgcgagggca acgccaacaa tttctacacc tgggaggctt 300gcgacgatgc ttgctggagg atagaaaaag ttcccaaagt ttgccggctg caagtgagtg 360tggacgacca gtgtgagggg tccacagaaa agtatttctt taatctaagt tccatgacat 420gtgaaaaatt cttttccggt gggtgtcacc ggaaccggat tgagaacagg tttccagatg 480aagctacttg tatgggcttc tgcgcaccaa agaaaattcc atcattttgc tacagtccaa 540aagatgaggg actgtgctct gccaatgtga ctcgctatta ttttaatcca agatacagaa 600cctgtgatgc tttcacctat actggctgtg gagggaatga caataacttt gttagcaggg 660aggattgcaa acgtgcatgt gcaaaagctt tgaaaaagaa aaagaagatg ccaaagcttc 720gctttgccag tagaatccgg aaaattcgga agaagcaatt ttaaacattc ttaatatgtc 780atcttgtttg tctttatggc ttatttgcct ttatggttgt atctgaagaa taatatgaca 840gcatgaggaa acaaatcatt ggtgatttat tcaccagttt ttattaatac aagtcacttt 900ttcaaaaatt tggatttttt tatatataac tagctgctat tcaaatgtga gtctaccatt 960tttaatttat ggttcaactg tttgtgagac gaattcttgc aatgcataag atataaaagc1020aaatatgact cactcatttc ttggggtcgt attcctgatt tcagaagagg atcataactg1080aaacaacata agacaatata atcatgtgct tttaacatat ttgagaataa aaaggactag1140cc 1142<210>24<211>235<212>PRT
<213>ÈË<220>
<221>×éÖ¯Òò×Ó;¾¶ÒÖÖÆ¼Á2<222>(1)..(235)<223>NP006519<400>24Met Asp Pro Ala Arg Pro Leu Gly Leu Ser Ile Leu Leu Leu Phe Leu1 5 10 15Thr Glu Ala Ala Leu Gly Asp Ala Ala Gln Glu Pro Thr Gly Asn Asn20 25 30Ala Glu Ile Cys Leu Leu Pro Leu Asp Tyr Gly Pro Cys Arg Ala Leu35 40 45Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg Gln Phe50 55 60Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr Trp Glu65 70 75 80Ala Cys Asp Asp Ala Cys Trp Arg Ile Glu Lys Val Pro Lys Val Cys85 90 95Arg Leu Gln Val Ser Val Asp Asp Gln Cys Glu Gly Ser Thr Glu Lys100 105 110Tyr Phe Phe Asn Leu Ser Ser Met Thr Cys Glu Lys Phe Phe Ser Gly115 120 125Gly Cys His Arg Asn Arg Ile Glu Asn Arg Phe Pro Asp Glu Ala Thr
130 135 140Cys Met Gly Phe Cys Ala Pro Lys Lys Ile Pro Ser Phe Cys Tyr Ser145 150 155 160Pro Lys Asp Glu Gly Leu Cys Ser Ala Asn Val Thr Arg Tyr Tyr Phe165 170 175Asn Pro Arg Tyr Arg Thr Cys Asp Ala Phe Thr Tyr Thr Gly Cys Gly180 185 190Gly Asn Asp Asn Asn Phe Val Ser Arg Glu Asp Cys Lys Arg Ala Cys195 200 205Ala Lys Ala Leu Lys Lys Lys Lys Lys Met Pro Lys Leu Arg Phe Ala210 215 220Ser Arg Ile Arg Lys Ile Arg Lys Lys Gln Phe225 230 235<210>25<211>5699<212>DMA<213>ÈË<220>
<221>ÁòËáõ¥Ã¸1<222>(1)..(5699)<223>NM015170
<400>25ggagttctca gacctccagt ttcagccctg ccctcagcct ccaatccgta agagacaccc 60agccccagca attggattgg gcagcccgtc ttgacacacc actgtgctga gtgcttgagg 120acgtgtttca acagatggtt ggggttagtg tgtgtcatca cattcgagtg gggattaaga 180gaaggaaggc tgccttgctg gagctgtgtg gtcttctcca agtgagagtc gcaggcaata 240gaactacttt gcttttggag gaaaaggagg aattcatttt cagcagacac aagaaaagca 300gttttttttt cagggattct tcacttctct tgaacaagga actcactcag agactaacac 360aaaggaagta atttcttacc tggtcattat ttagtctaca ataagttcat ccttcttcag 420tgtgaccagt aaattcttcc catactcttg aagagagcat aattggaatg gagaggtggt 480gctgacggcc acccaccatc atctaaagaa gataaacttg gcaaatgaca tgcaggttct 540tcaaggcaga ataattgcag aaaatcttca aaggacccta tctgcagatg ttctgaatac 600ctctgagaat agagattgat tattcaacca ggatacctaa ttcaagaact ccagaaatca 660ggagacggag acattttgtc agttttgcaa cattggacca aatacaatga agtattcttg 720ctgtgctctg gttttggctg tcctgggcac agaattgctg ggaagcctct gttcgactgt 780cagatccccg aggttcagag gacggataca gcaggaacga aaaaacatcc gacccaacat 840tattcttgtg cctaccgatg atcaagatgt ggagctgggg tccctgcaag tcatgaacaa 900aacgagaaag attatggaac atgggggggc caccttcatc aatgcctttg tgactacacc 960catgtgctgc ccgtcacggt cctccatgct caccgggaag tatgtgcaca atcacaatgt1020ctacaccaac aacgagaact gctcttcccc ctcgtggcag gccatgcatg agcctcggac1080ttttgctgta tatcttaaca acactggcta cagaacagcc ttttttggaa aatacctcaa1140tgaatataat ggcagctaca tcccccctgg gtggcgagaa tggcttggat taatcaagaa1200ttctcgcttc tataattaca ctgtttgtcg caatggcatc aaagaaaagc atggatttga1260ttatgcaaag gactacttca cagacttaat cactaacgag agcattaatt acttcaaaat1320gtctaagaga atgtatcccc ataggcccgt tatgatggtg atcagccacg ctgcgcccca1380
cggccccgag gactcagccc cacagttttc taaactgtac cccaatgctt cccaacacat 1440aactcctagt tataactatg caccaaatat ggataaacac tggattatgc agtacacagg 1500accaatgctg cccatccaca tggaatttac aaacattcta cagcgcaaaa ggctccagac 1560tttgatgtca gtggatgatt ctgtggagag gctgtataac atgctcgtgg agacggggga 1620gctggagaat acttacatca tttacaccgc cgaccatggt taccatattg ggcagtttgg 1680actggtcaag gggaaatcca tgccatatga ctttgatatt cgtgtgcctt tttttattcg 1740tggtccaagt gtagaaccag gatcaatagt cccacagatc gttctcaaca ttgacttggc 1800ccccacgatc ctggatattg ctgggctcga cacacctcct gatgtggacg gcaagtctgt 1860cctcaaactt ctggacccag aaaagccagg taacaggttt cgaacaaaca agaaggccaa 1920aatttggcgt gatacattcc tagtggaaag aggcaaattt ctacgtaaga aggaagaatc 1980cagcaagaat atccaacagt caaatcactt gcccaaatat gaacgggtca aagaactatg 2040ccagcaggcc aggtaccaga cagcctgtga acaaccgggg cagaagtggc aatgcattga 2100ggatacatct ggcaagcttc gaattcacaa gtgtaaagga cccagtgacc tgctcacagt 2160ccggcagagc acgcggaacc tctacgctcg cggcttccat gacaaagaca aagagtgcag 2220ttgtagggag tctggttacc gtgccagcag aagccaaaga aagagtcaac ggcaattctt 2280gagaaaccag gggactccaa agtacaagcc cagatttgtc catactcggc agacacgttc 2340cttgtccgtc gaatttgaag gtgaaatata tgacataaat ctggaagaag aagaagaatt 2400gcaagtgttg caaccaagaa acattgctaa gcgtcatgat gaaggccaca aggggccaag 2460agatctccag gcttccagtg gtggcaacag gggcaggatg ctggcagata gcagcaacgc 2520cgtgggccca cctaccactg tccgagtgac acacaagtgt tttattcttc ccaatgactc 2580tatccattgt gagagagaac tgtaccaatc ggccagagcg tggaaggacc ataaggcata 2640cattgacaaa gagattgaag ctctgcaaga taaaattaag aatttaagag aagtgagagg 2700acatctgaag agaaggaagc ctgaggaatg tagctgcagt aaacaaagct attacaataa 2760agagaaaggt gtaaaaaagc aagagaaatt aaagagccat cttcacccat tcaaggaggc 2820
tgctcaggaa gtagatagca aactgcaact tttcaaggag aacaaccgta ggaggaagaa 2880ggagaggaag gagaagagac ggcagaggaa gggggaagag tgcagcctgc ctggcctcac 2940ttgcttcacg catgacaaca accactggca gacagccccg ttctggaacc tgggatcttt 3000ctgtgcttgc acgagttcta acaataacac ctactggtgt ttgcgtacag ttaatgagac 3060gcataatttt cttttctgtg agtttgctac tggctttttg gagtattttg atatgaatac 3120agatccttat cagctcacaa atacagtgca cacggtagaa cgaggcattt tgaatcagct 3180acacgtacaa ctaatggagc tcagaagctg tcaaggatat aagcagtgca acccaagacc 3240taagaatctt gatgttggaa ataaagatgg aggaagctat gacctacaca gaggacagtt 3300atgggatgga tgggaaggtt aatcagcccc gtctcactgc agacatcaac tggcaaggcc 3360tagaggagct acacagtgtg aatgaaaaca tctatgagta cagacaaaac tacagactta 3420gtctggtgga ctggactaat tacttgaagg atttagatag agtatttgca ctgctgaaga 3480gtcactatga gcaaaataaa acaaataaga ctcaaactgc tcaaagtgac gggttcttgg 3540ttgtctctgc tgagcacgct gtgtcaatgg agatggcctc tgctgactca gatgaagacc 3600caaggcataa ggttgggaaa acacctcatt tgaccttgcc agctgacctt caaaccctgc 3660atttgaaccg accaacatta agtccagaga gtaaacttga atggaataac gacattccag 3720aagttaatca tttgaattct gaacactgga gaaaaaccga aaaatggacg gggcatgaag 3780agactaatca tctggaaacc gatttcagtg gcgatggcat gacagagcta gagctcgggc 3840ccagccccag gctgcagccc attcgcaggc acccgaaaga acttccccag tatggtggtc 3900ctggaaagga catttttgaa gatcaactat atcttcctgt gcattccgat ggaatttcag 3960ttcatcagat gttcaccatg gccaccgcag aacaccgaag taattccagc atagcgggga 4020agatgttgac caaggtggag aagaatcacg aaaaggagaa gtcacagcac ctagaaggca 4080gcgcctcctc ttcactctcc tctgattaga tgaaactgtt accttaccct aaacacagta 4140tttcttttta acttttttat ttgtaaacta ataaaggtaa tcacagccac caacattcca 4200agctaccctg ggtacctttg tgcagtagaa gctagtgagc atgtgagcaa gcggtgtgca 4260
cacggagact catcgttata atttactatc tgccaagagt agaaagaaag gctggggata4320tttgggttgg cttggttttg attttttgct tgtttgtttg ttttgtacta aaacagtatt4380atcttttgaa tatcgtaggg acataagtat atacatgtta tccaatcaag atggctagaa4440tggtgccttt ctgagtgtct aaaacttgac acccctggta aatctttcaa cacacttcca4500ctgcctgcgt aatgaagttt tgattcattt ttaaccactg gaatttttca atgccgtcat4560tttcagttag atgattttgc actttgagat taaaatgcca tgtctatttg attagtctta4620tttttttatt tttacaggct tatcagtctc actgttggct gtcattgtga caaagtcaaa4680taaaccccca aggacgacac acagtatgga tcacatattg tttgacatta agcttttgcc4740agaaaatgtt gcatgtgttt tacctcgact tgctaaaatc gattagcaga aaggcatggc4800taataatgtt ggtggtgaaa ataaataaat aagtaaacaa aatgaagatt gcctgctctc4860tctgtgccta gcctcaaagc gttcatcata catcatacct ttaagattgc tatattttgg4920gttattttct tgacaggaga aaaagatcta aagatctttt attttcatct tttttggttt4980tcttggcatg actaagaagc ttaaatgttg ataaaatatg actagttttg aatttacacc5040aagaacttct caataaaaga aaatcatgaa tgctccacaa tttcaacata ccacaagaga5100agttaatttc ttaacattgt gttctatgat tatttgtaag accttcacca agttctgata5160tcttttaaag acatagttca aaattgcttt tgaaaatctg tattcttgaa aatatccttg5220ttgtgtatta ggtttttaaa taccagctaa aggattacct cactgagtca tcagtaccct5280cctattcagc tccccaagat gatgtgtttt tgcttaccct aagagaggtt ttcttcttat5340ttttagataa ttcaagtgct tagataaatt atgttttctt taagtgttta tggtaaactc5400ttttaaagaa aatttaatat gttatagctg aatctttttg gtaactttaa atctttatca5460tagactctgt acatatgttc aaattagctg cttgcctgat gtgtgtatca tcggtgggat5520gacagaacaa acatatttat gatcatgaat aatgtgcttt gtaaaaagat ttcaagttat5580taggaagcat actctgtttt ttaatcatgt ataatattcc atgatacttt tatagaacaa5640ttctggcttc aggaaagtct agaagcaata tttcttcaaa taaaaggtgt ttaaacttt 5699
<210>26<211>871<212>PRT<213>ÈË<220>
<221>ÁòËáõ¥Ã¸1<222>(1)..(871)<223>NP055985<400>26Met Lys Tyr Ser Cys Cys Ala Leu Val Leu Ala Val Leu Gly Thr Glu1 5 10 15Leu Leu Gly Ser Leu Cys Ser Thr Val Arg Ser Pro Arg Phe Arg Gly20 25 30Arg Ile Gln Gln Glu Arg Lys Asn Ile Arg Pro Asn Ile Ile Leu Val35 40 45Pro Thr Asp Asp Gln Asp Val Glu Leu Gly Ser Leu Gln Val Met Asn50 55 60Lys Thr Arg Lys Ile Met Glu His Gly Gly Ala Thr Phe Ile Asn Ala65 70 75 80Phe Val Thr Thr Pro Met Cys Cys Pro Ser Arg Ser Ser Met Leu Thr85 90 95
Gly Lys Tyr Val His Asn His Asn Val Tyr Thr Asn Asn Glu Asn Cys100 105 110Ser Ser Pro Ser Trp Gln Ala Met His Glu Pro Arg Thr Phe Ala Val115 120 125Tyr Leu Asn Asn Thr Gly Tyr Arg Thr Ala Phe Phe Gly Lys Tyr Leu130 135 140Asn Glu Tyr Asn Gly Ser Tyr Ile Pro Pro Gly Trp Arg Glu Trp Leu145 150 155 160Gly Leu Ile Lys Asn Ser Arg Phe Tyr Asn Tyr Thr Val Cys Arg Asn165 170 175Gly Ile Lys Glu Lys His Gly Phe Asp Tyr Ala Lys Asp Tyr Phe Thr180 185 190Asp Leu Ile Thr Asn Glu Ser Ile Asn Tyr Phe Lys Met Ser Lys Arg195 200 205Met Tyr Pro His Arg Pro Val Met Met Val Ile Ser His Ala Ala Pro210 215 220His Gly Pro Glu Asp Ser Ala Pro Gln Phe Ser Lys Leu Tyr Pro Asn225 230 235 240Ala Ser Gln His Ile Thr Pro Ser Tyr Asn Tyr Ala Pro Asn Met Asp245 250 255Lys His Trp Ile Met Gln Tyr Thr Gly Pro Met Leu Pro Ile His Met260 265 270Glu Phe Thr Asn Ile Leu Gln Arg Lys Arg Leu Gln Thr Leu Met Ser275 280 285
Val Asp Asp Ser Val Glu Arg Leu Tyr Asn Met Leu Val Glu Thr Gly290 295 300Glu Leu Glu Asn Thr Tyr Ile Ile Tyr Thr Ala Asp His Gly Tyr His305 310 315 320Ile Gly Gln Phe Gly Leu Val Lys Gly Lys Ser Met Pro Tyr Asp Phe325 330 335Asp Ile Arg Val Pro Phe Phe Ile Arg Gly Pro Ser Val Glu Pro Gly340 345 350Ser Ile Val Pro Gln Ile Val Leu Asn Ile Asp Leu Ala Pro Thr Ile355 360 365Leu Asp Ile Ala Gly Leu Asp Thr Pro Pro Asp Val Asp Gly Lys Ser370 375 380Val Leu Lys Leu Leu Asp Pro Glu Lys Pro Gly Asn Arg Phe Arg Thr385 390 395 400Asn Lys Lys Ala Lys Ile Trp Arg Asp Thr Phe Leu Val Glu Arg Gly405 410 415Lys Phe Leu Arg Lys Lys Glu Glu Ser Ser Lys Asn Ile Gln Gln Ser420 425 430Asn His Leu Pro Lys Tyr Glu Arg Val Lys Glu Leu Cys Gln Gln Ala435 440 445Arg Tyr Gln Thr Ala Cys Glu Gln Pro Gly Gln Lys Trp Gln Cys Ile450 455 460Glu Asp Thr Ser Gly Lys Leu Arg Ile His Lys Cys Lys Gly Pro Ser465 470 475 480
Asp Leu Leu Thr Val Arg Gln Ser Thr Arg Asn Leu Tyr Ala Arg Gly485 490 495Phe His Asp Lys Asp Lys Glu Cys Ser Cys Arg Glu Ser Gly Tyr Arg500 505 510Ala Ser Arg Ser Gln Arg Lys Ser Gln Arg Gln Phe Leu Arg Asn Gln515 520 525Gly Thr Pro Lys Tyr Lys Pro Arg Phe Val His Thr Arg Gln Thr Arg530 535 540Ser Leu Ser Val Glu Phe Glu Gly Glu Ile Tyr Asp Ile Asn Leu Glu545 550 555 560Glu Glu Glu Glu Leu Gln Val Leu Gln Pro Arg Asn Ile Ala Lys Arg565 570 575His Asp Glu Gly His Lys Gly Pro Arg Asp Leu Gln Ala Ser Ser Gly580 585 590Gly Asn Arg Gly Arg Met Leu Ala Asp Ser Ser Asn Ala Val Gly Pro595 600 605Pro Thr Thr Val Arg Val Thr His Lys Cys Phe Ile Leu Pro Asn Asp610 615 620Ser Ile His Cys Glu Arg Glu Leu Tyr Gln Ser Ala Arg Ala Trp Lys625 630 635 640Asp His Lys Ala Tyr Ile Asp Lys Glu Ile Glu Ala Leu Gln Asp Lys645 650 655Ile Lys Asn Leu Arg Glu Val Arg Gly His Leu Lys Arg Arg Lys Pro660 665 670
Glu Glu Cys Ser Cys Ser Lys Gln Ser Tyr Tyr Asn Lys Glu Lys Gly675 680 685Val Lys Lys Gln Glu Lys Leu Lys Ser His Leu His Pro Phe Lys Glu690 695 700Ala Ala Gln Glu Val Asp Ser Lys Leu Gln Leu Phe Lys Glu Asn Asn705 710 715 720Arg Arg Arg Lys Lys Glu Arg Lys Glu Lys Arg Arg Gln Arg Lys Gly725 730 735Glu Glu Cys Ser Leu Pro Gly Leu Thr Cys Phe Thr His Asp Asn Asn740 745 750His Trp Gln Thr Ala Pro Phe Trp Asn Leu Gly Ser Phe Cys Ala Cys755 760 765Thr Ser Ser Asn Asn Asn Thr Tyr Trp Cys Leu Arg Thr Val Asn Glu770 775 780Thr His Asn Phe Leu Phe Cys Glu Phe Ala Thr Gly Phe Leu Glu Tyr785 790 795 800Phe Asp Met Asn Thr Asp Pro Tyr Gln Leu Thr Asn Thr Val His Thr805 810 815Val Glu Arg Gly Ile Leu Asn Gln Leu His Val Gln Leu Met Glu Leu820 825 830Arg Ser Cys Gln Gly Tyr Lys Gln Cys Asn Pro Arg Pro Lys Asn Leu835 840 845Asp Val Gly Asn Lys Asp Gly Gly Ser Tyr Asp Leu His Arg Gly Gln850 855 860
Leu Trp Asp Gly Trp Glu Gly865 870<210>27<211>1433<212>DNA<213>ÈË<220>
<221>IGFBP2<222>(1)..(1433)<223>NM000597<400>27attcggggcg agggaggagg aagaagcgga ggaggcggct cccgctcgca gggccgtgca 60cctgcccgcc cgcccgctcg ctcgctcgcc cgccgcgccg cgctgccgac cgccagcatg 120ctgccgagag tgggctgccc cgcgctgccg ctgccgccgc cgccgctgct gccgctgctg 180ccgctgctgc tgctgctact gggcgcgagt ggcggcggcg gcggggcgcg cgcggaggtg 240ctgttccgct gcccgccctg cacacccgag cgcctggccg cctgcgggcc cccgccggtt 300gcgccgcccg ccgcggtggc cgcagtggcc ggaggcgccc gcatgccatg cgcggagctc 360gtccgggagc cgggctgcgg ctgctgctcg gtgtgcgccc ggctggaggg cgaggcgtgc 420ggcgtctaca ccccgcgctg cggccagggg ctgcgctgct atccccaccc gggctccgag 480ctgcccctgc aggcgctggt catgggcgag ggcacttgtg agaagcgccg ggacgccgag 540tatggcgcca gcccggagca ggttgcagac aatggcgatg accactcaga aggaggcctg 600
gtggagaacc acgtggacag caccatgaac atgttgggcg ggggaggcag tgctggccgg660aagcccctca agtcgggtat gaaggagctg gccgtgttcc gggagaaggt cactgagcag720caccggcaga tgggcaaggg tggcaagcat caccttggcc tggaggagcc caagaagctg780cgaccacccc ctgccaggac tccctgccaa caggaactgg accaggtcct ggagcggatc840tccaccatgc gccttccgga tgagcggggc cctctggagc acctctactc cctgcacatc900cccaactgtg acaagcatgg cctgtacaac ctcaaacagt gcaagatgtc tctgaacggg960cagcgtgggg agtgctggtg tgtgaacccc aacaccggga agctgatcca gggagccccc 1020accatccggg gggaccccga gtgtcatctc ttctacaatg agcagcagga ggcttgcggg 1080gtgcacaccc agcggatgca gtagaccgca gccagccggt gcctggcgcc cctgcccccc 1140gcccctctcc aaacaccggc agaaaacgga gagtgcttgg gtggtgggtg ctggaggatt 1200ttccagttct gacacacgta tttatatttg gaaagagacc agcaccgagc tcggcacctc 1260cccggcctct ctcttcccag ctgcagatgc cacacctgct ccttcttgct ttccccgggg 1320gaggaagggg gttgtggtcg gggagctggg gtacaggttt ggggaggggg aagagaaatt 1380tttatttttg aacccctgtg tcccttttgc ataagattaa aggaaggaaa agt 1433<210>28<211>328<212>PRT<213>ÈË<220>
<221>IGFBP2<222>(1)..(328)<223>NP000588
<400>28Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro1 5 10 15Leu Leu Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly20 25 30Gly Gly Gly Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys35 40 45Thr Pro Glu Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro50 55 60Ala Ala Val Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu65 70 75 80Leu Val Arg Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu85 90 95Glu Gly Glu Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu100 105 110Arg Cys Tyr Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val115 120 125Met Gly Glu Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala130 135 140Ser Pro Glu Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly145 150 155 160Leu Val Glu Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly165170 175
Gly Ser Ala Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala180 185 190Val Phe Arg Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly195 200 205Gly Lys His His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro210 215 220Pro Ala Arg Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg225 230 235 240Ile Ser Thr Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu245 250 255Tyr Ser Leu His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu260 265 270Lys Gln Cys Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys275 280 285Val Asn Pro Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg290 295 300Gly Asp Pro Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Cys305 310 315 320Gly Val His Thr Gln Arg Met Gln325<210>29<211>627
<212>DNA<213>ÈË<220>
<221>°ëë×°±Ëáµ°°×øÒÖÖÆ¼ÁE/M<222>(1)..(627)<223>NM001323<400>29gcggccgcaa gctcggcact cacggctctg agggctccga cggcactgac ggccatggcg 60cgttcgaacc tcccgctggc gctgggcctg gccctggtcg cattctgcct cctggcgctg120ccacgcgacg cccgggcccg gccgcaggag cgcatggtcg gagaactccg ggacctgtcg180cccgacgacc cgcaggtgca gaaggcggcg caggcggccg tggccagcta caacatgggc240agcaacagca tctactactt ccgagacacg cacatcatca aggcgcagag ccagctggtg300gccggcatca agtacttcct gacgatggag atggggagca cagactgccg caagaccagg360gtcactggag accacgtcga cctcaccact tgccccctgg cagcaggggc gcagcaggag420aagctgcgct gtgactttga ggtccttgtg gttccctggc agaactcctc tcagctccta480aagcacaact gtgtgcagat gtgataagtc cccgagggcg aaggccattg ggtttggggc540catggtggag ggcacttcag gtccgtgggc cgtatctgtc acaataaatg gccagtgctg600cttcttgcaa aaaaaaaaaa aaaaaaa627<210>30<211>149<212>PRT
<213>ÈË<220>
<221>°ëë×°±Ëáµ°°×øÒÖÖÆ¼ÁE/M<222>(1)..(149)<223>NP001314<400>30Met Ala Arg Ser Asn Leu Pro Leu Ala Leu Gly Leu Ala Leu Val Ala1 5 10 15Phe Cys Leu Leu Ala Leu Pro Arg Asp Ala Arg Ala Arg Pro Gln Glu20 25 30Arg Met Val Gly Glu Leu Arg Asp Leu Ser Pro Asp Asp Pro Gln Val35 40 45Gln Lys Ala Ala Gln Ala Ala Val Ala Ser Tyr Asn Met Gly Ser Asn50 55 60Ser Ile Tyr Tyr Phe Arg Asp Thr His Ile Ile Lys Ala Gln Ser Gln65 70 75 80Leu Val Ala Gly Ile Lys Tyr Phe Leu Thr Met Glu Met Gly Ser Thr85 90 95Asp Cys Arg Lys Thr Arg Val Thr Gly Asp His Val Asp Leu Thr Thr100 105 110Cys Pro Leu Ala Ala Gly Ala Gln Gln Glu Lys Leu Arg Cys Asp Phe115 120 125Glu Val Leu Val Val Pro Trp Gln Asn Ser Ser Gln Leu Leu Lys His
130 135 140Asn Cys Val Gln Met145<210>31<211>11025<212>DNA<213>ÈË<220>
<221>ÈÑÉïÏà¹ØÑª½¬µ°°×A<222>(1)..(11025)<223>NM002581<400>31gagcatcttt tggggggagg gaattcagcg gatcagtctt aagaggagct tttttttgga 60gcgagaaatc atataaaata aaatgaaata aaacaaggag gaaggcaacc agctgttagg120ggaaaaataa ggcagataaa ggagcgggga gagaaattaa ttgccaacca ggaggagttg180ggctgtattt ttcaaaggtg gggagagtgg agcacacacc ttgaggagga aagcgagaaa240gaaaagaaaa aagcaagtgg aaaggggggc tcgcccaaga agggtgaaga agcgaagaaa300gtcgaggcgc cgaggctccc aaagctggca gctccgggtg gcggtgcagg ggcgaagggg360gggcgggggg aaccgtcgga catgcggctc tggagttggg tgctgcacct ggggctgctg420agcgccgcgc tgggctgcgg gctggccgag cgtccccgcc gggcccggag agacccgcgg480gccggccgac ccccgcgccc cgccgccggc ccggccacct gcgccacccg ggcggcccgc540
ggccgccgcg cctcgccgcc gccgccgccg ccgccgggcg gtgcctggga agccgtgcgc600gtcccccggc ggcggcagca gcgggaggcg aggggcgcca ccgaggagcc gagcccgccg660agccgggcgc tctatttcag cgggcgaggc gagcagctgc gcctccgggc cgacctcgag720ctgccccggg acgcgttcac gctgcaagtg tggctgcgag cggagggggg ccagaggtct780ccggcagtga tcacagggct gtatgacaaa tgttcttata tctcacgtga ccgaggatgg840gtcgtgggca ttcacaccat cagtgaccaa gacaacaaag acccacgcta ctttttctcc900ttgaagacag accgagcccg gcaagtgacc accatcaatg cccaccgcag ctacctccca960ggccagtggg tatacctagc tgccacctat gatgggcagt tcatgaagct ctatgtgaat 1020ggtgcccagg tggccacctc tggggaacaa gtgggtggca tattcagccc actgacccag 1080aagtgcaaag tgctcatgtt agggggcagt gccctgaatc acaactaccg gggctacatc 1140gagcacttca gtctgtggaa ggtggccagg actcagcggg agatactgtc tgacatggaa 1200acccatggcg cccacactgc tctacctcag ctcctcctcc aggagaactg ggacaatgtg 1260aagcatgcct ggtcccccat gaaggatggc agcagcccca aagtggaatt cagcaatgcc 1320cacggctttc tgctggacac gagtctggag cctcctctgt gcggacagac attgtgtgac 1380aacacagagg tcattgccag ctacaatcag ctctcaagtt tccgccagcc caaggtggtg 1440cgctaccgcg tggtcaacct ctatgaagat gatcataaga acccgacggt gacgcgcgag 1500caggtggact tccagcacca tcagctggct gaggccttca agcaatacaa catctcctgg 1560gagctggacg tgctggaggt gagcaactcc tcccttcgcc gccgcctcat cctggccaac 1620tgtgacatca gcaagattgg ggatgagaac tgtgaccccg agtgcaacca cacgctgacg 1680ggccacgacg gcggggattg ccgccacctg cgccaccctg ccttcgtgaa gaagcagcac 1740aacggggtgt gtgacatgga ctgcaactat gaacggttca actttgatgg tggagagtgc 1800tgtgaccctg aaatcaccaa tgtcactcag acttgctttg accccgactc tccacacaga 1860gcctacttgg atgttaatga gctgaagaac attcttaaat tggatggatc aacacatctc 1920aatattttct ttgcaaaatc ctcagaggag gagttggcag gagtagcaac ttggccatgg 1980
gacaaggagg ccctgatgca cttaggtggc attgtcttga acccatcttt ctatggcatg2040cctgggcaca cccacaccat gatccatgag attggtcaca gcctgggcct ctatcacgtc2100ttccgaggca tctcagaaat ccagtcctgc agtgacccct gcatggagac agagccctcc2160ttcgagactg gagacctctg caatgatacc aacccagccc ctaaacacaa gtcctgtggt2220gacccagggc caggaaatga cacctgtggc tttcatagct tcttcaacac tccttacaac2280aacttcatga gctatgcaga tgacgactgt acggactcct tcacgcccaa tcaagtcgcc2340agaatgcact gttacctgga cctggtctac cagggctggc agccctccag gaaaccagcg2400cctgttgccc tcgcccccca agttctgggc cacacaacgg actctgtgac actggagtgg2460ttcccaccta tagatggcca tttctttgaa agagaattgg gatcagcatg tcatctttgc2520ctggaaggga gaatcctggt gcagtatgct tccaacgctt cctccccaat gccctgcagc2580ccatcaggac actggagccc tcgtgaagca gaaggtcatc ctgatgttga acagccctgt2640aagtccagtg tccgcacctg gagcccaaat tcagctgtca acccacacac ggttcctcca2700gcctgccctg agcctcaagg ctgctacctc gagctggagt tcctctaccc cttggtccct2760gagtctctga ccatttgggt gacctttgtc tccactgact gggactctag tggagctgtc2820aatgacatca aactgttggc tgtcagtggg aagaacatct ccctgggtcc tcagaatgtc2880ttctgtgatg tcccactgac catcagactc tgggacgtgg gcgaggaggt gtatggcatc2940caaatctaca cgctggatga gcacctggag atcgatgctg ccatgttgac ctccactgca3000gacaccccac tctgtctaca gtgtaagccc ctgaagtata aggtggtccg ggaccctcct3060ctccagatgg atgtggcctc catcctacat ctcaatagga aattcgtaga catggatcta3120aatcttggca gtgtgtacca gtattgggtc ataactattt caggaactga agagagtgag3180ccatcacctg ctgtcacata catccatgga agtgggtact gtggcgatgg cattatacaa3240aaagaccaag gtgaacaatg cgacgacatg aataagatca atggtgatgg ctgctccctt3300ttctgccgac aagaagtctc cttcaattgt attgatgaac ccagccggtg ctatttccat3360gatggtgatg gggtatgtga ggagtttgaa caaaaaacca gcattaagga ctgtggtgtc3420
tacacgcccc agggattcct ggatcagtgg gcatccaatg cttcagtatc tcatcaagac 3480cagcaatgcc caggctgggt catcatcgga cagccagcag catcccaggt gtgtcgaacc 3540aaggtgatag atctcagtga aggcatttcc cagcatgcct ggtacccttg caccatcagc 3600tacccatatt cccagctggc tcagaccact ttttggctcc gggcgtattt ttctcaacca 3660atggttgccg cagctgtcat tgtccacctg gtgacggatg ggacatatta tggggaccaa 3720aagcaggaga ccatcagcgt gcagctgctt gataccaaag atcagagcca cgatctaggc 3780ctccatgtcc tgagctgcag gaacaatccc ctgattatcc ctgtggtcca tgacctcagc 3840cagcccttct accacagcca ggcggtacgt gtgagcttca gttcgcccct ggtcgccatc 3900tcgggggtgg ccctccgttc cttcgacaac tttgaccccg tcaccctgag cagctgccag 3960agaggggaga cctacagccc tgccgagcag agctgcgtgc acttcgcatg tgagaaaact 4020gactgtccag agctggctgt ggagaatgct tctctcaatt gctccagcag cgaccgctac 4080cacggtgccc agtgtactgt gagctgccgg acaggctacg tgctccagat acggcgggat 4140gatgagctga tcaagagcca gacgggaccc agcgtcacag tgacctgtac agagggcaag 4200tggaataagc aggtggcctg tgagccagtc gactgcagca tcccagatca ccatcaagtc 4260tatgctgcct ccttctcctg ccctgagggc accacctttg gcagtcaatg ttccttccag 4320tgccgtcacc ctgcacaatt gaaaggcaac aacagcctcc tgacctgcat ggaggatggg 4380ctgtggtcct tcccagaggc cctgtgtgag ctcatgtgcc tcgctccacc ccctgtgccc 4440aatgcagacc tccagaccgc ccggtgccga gagaataagc acaaggtggg ctccttctgc 4500aaatacaaat gcaagcctgg ataccatgtg cctggatcct ctcggaagtc aaagaaacgg 4560gccttcaaga ctcagtgtac ccaggatggc agctggcagg agggagcttg tgttcctgtg 4620acctgtgacc cacctccacc aaaattccat gggctctacc agtgtactaa tggcttccag 4680ttcaacagtg agtgtaggat caagtgtgaa gacagtgatg cctcccaggg acttgggagc 4740aatgtcattc attgccggaa agatggcacc tggaacggct ccttccatgt ctgccaggag 4800atgcaaggcc agtgctcggt tccaaacgag ctcaacagca acctcaaact gcagtgccct 4860
gatggctatg ccatagggtc ggagtgtgcc acctcgtgcc tggaccacaa cagcgagtcc 4920atcatcctgc caatgaacgt gaccgtgcgt gacatccccc actggctgaa ccccacacgg 4980gtagagagag ttgtctgcac tgctggtctc aagtggtatc ctcaccctgc tctgattcac 5040tgtgtcaaag gctgtgagcc cttcatggga gacaattatt gtgatgccat caacaaccga 5100gccttttgca actatgacgg tggggattgc tgcacctcca cagtgaagac caaaaaggtc 5160accccattcc ctatgtcctg tgatctacaa ggtgactgtg cttgtcggga cccccaggcc 5220caagaacaca gccggaaaga cctccgggga tacagccatg gctaaggaag gacaagaagt 5280tgtcaaagaa ttcccaacgc caggacccac atccctttgg tattgatttc acagtcagct 5340gctcaacgga atggcctctc cacaccaggg atccttagca cccaaccggt ctgcctttaa 5400ttttacccag gaaggactca cattggggcg aatgaaccaa gtttcgccat gctggatgat 5460gaaatggatt cccatcccaa agtctgagat ggattgcata tacagtgtgc agtcccagag 5520cctcctaaaa ttctagccat ttgtcacaca accacagcaa gaaacgtgtt ctatatctag 5580agtgtgccca tctgtgttta gtacacatgc atgcatacac acccatacaa acatctgtgt 5640gagggcagtt ctggagatga gcagagagag accggaataa actcaatctt ttctttccca 5700agctcctagc caacactatc cttgggagaa agaaatttgc agaaactgct aagaccaagt 5760gtggagatgt caagctagtt cacactctga ggctcagaat atgtaggaca tgcacaattg 5820tgcagtcctt tgggattgga agtgaaacag tctgtgatcc cctaccttct agggaactag 5880gacctaggaa gaggtaaaga ttatcaggta tgcaaagcgc cccaattctt ctgctgccat 5940gggggatttt accccaactc cagggttcga ggccaatctg agaatggctt aggattgcaa 6000tgtcaaggta ttatatcagc cccttgcttg aggcttgagg tcataatatc cctctaggac 6060ttacctgttc ccccagatct tgccttggga ccacatttgc tgctactttt cctgctgctc 6120tatcctatac attgaataat ccaagatggt agaactaggt taggaaaaat tccacacaac 6180caaacagtct gccttaaaag tgacccacat ttttccatag ctcctcactt tttagccctt 6240ctgcaagaga aaaaccctca tgggtccaca tggtgagaag ttaagtttcc tgtaagtggg 6300
cctctcaccc tggaaaggag ttgagggaca tcagatgctg gaaccctcac tgaaagtcca 6360gaatgtctaa gccagtgtta gattttgtaa acaagtggaa cagtgttaaa tttctatgat 6420gttggagcca tccagagact actggaattg tcgagacttt tggattatta tccttatcct 6480tatcctaatc ttcctagccc ttcaggctag agtaggcttc gatcctgaga accttgctgt 6540tgctctgagg agatataatt ctgggagaaa gaatctttta taagaacagt acagattgtt 6600ctcaagaggg ccatcagaag gaagccaaag agttcacagc ctcagcacca acaactcaac 6660atggtcatca tgttttctat atggtttttc cagctagcag tactcccttc catacctgtg 6720actgggcagt gcttttctct ctcccatgtc tagcctccaa aagttaagtg aaaattagtc 6780aactgcacgt ggaagccccc accactttgg ggatctcttt atttcttttc agccagggac 6840ctgtccactc cctttgaatt aatatgggaa gaaattaata caggatgaac tggagagaag 6900ggttgagtgt ggcatacttt ctgaaacctg gagctgggaa ttgcggagaa gggaaggtct 6960agactagtta catcacatag ggattactgt aaatcaagtc atctcaagtc tagtgaagac 7020agccaacaga aacaaaacct agcataggga tagaaaatac catgcacgtg tgcagcccca 7080cctaattcct gcatccaagg caggtgttgt taatctatca tagcacttaa aaaaaaaaaa 7140aaaaagagac caaaaataac tttaggaacc accatattat atcactccca atagcactga 7200cctggtgatc aaaaacactt gagaagacat ctattggcca tctctggcca attacactaa 7260gaaacatatc aaggtgcttt tggcacaggt gcccacaaat acggatgcag tgctgagata 7320gtttatgaga cttgtaccat ttcacaaact ctgaaattgg gttccatatt ggcaaggctg 7380ccacagttgt taagaataat cctctatgtt tcttcctcac aaaaccatat ctcatttata 7440tccagaccat tacttcacta taattacaag gacaaattat tagcaagaaa taagaatagt 7500attagaagaa ttgatcctat tttgaacccc tctccagtat cttcacactc ttgtcaactc 7560tccaggcctc tctcttgccc tgagttatca gcctgtgtgg tgttaactac cttagaaggt 7620acaagctaag aaatgtaaca gtatcaaccc tcccagttgc ttaattatac ccataggtaa 7680tacaaaaagc tctgaagacc caaagatgac attactaatg atgtgatttc aggagccaca 7740
gaagaacctt accagcttcc ctcaaatcag tccttatcct ctttctatct tcactcccat 7800catcatctat tttcacacta tccagctaag caaagattcc tggaggctga cttgtatctt 7860cagactcaca gagtgaattc agctcttctg aatcaagacc cacccagtct ctttcattca 7920gacctgttgc taacaaattt atatttgcca aggatattag gcaaaagagg ctacttgatt 7980ggtggccaac ctcgtgccca catggaaggt atctttaata gggtcttttc aaaccttagt 8040ggaggagggt cagctcaatt tgggcaatgc atttgttccc agtttcattt tcttcctggg 8100aattaactcg tcatttcatt ccttcagtca tcttctgtgt aggtgaccgg agcactgaga 8160ggcagctctg atgcactatt gtgtgtcagc agctcaaagg ccctaaaaca ctgaaggttc 8220tgcatctgaa gtattagatt gttagcagca aaatatgaaa gatgaggtgg acagtcctct 8280aagccctatt tagggaagct tttccaagcc acaatcttaa ctacctaccc aaaggatttg 8340cattaccccc agattctgtg ccaacaacct tttaaggaaa tacagtcctt gggaaatgag 8400ttttgatggt gaattggggt gttaaggaag ggaaagattg tcatagatgg tagggctttg 8460aaaatgcagg gtatcagctg ccactcctgg cttcaacaca ttgagtcact gcctagacgg 8520ttctcttggt cttattccca tcctggccaa tgcttaaata ctatttgttg aaaataattc 8580tttgagacag atttcagcta cctcccttcc aggttcgatt taacttggtt gtaattgtca 8640atttgttgtt ataggtctta cctgtgtgaa agaaagaaaa agaaagaaag aaagaaagag 8700aaaggaaatt ataaggtcaa gttaacagtt ttgaggtttt gtgttttttt ctggaactac 8760ttcaagtgag aaaataaaaa aaaatggtga caaagctgta cagatagaga taatagaaga 8820caaagagatt aaaaggaaat aaaaatgcat gattaaaaac taagaataaa aaacctattt 8880ttatgtttcc taaaggaaat tgtttattct acagcctcag taggtagaca caaacataaa 8940gatttcccta gaagacatag agtgggattt gataacactg tctgttattt tctgtacatt 9000gtggtaggtc caggaaatat gacattttcc cccttgatgt gttattgttg ttgttgggtg 9060gggtgggcat tttgtttatt tgtttggtgg caatcagtgg tagtagggag tgggagggct 9120tatattggtt tttccagcta ttaaggggac atattgtgtc gttgtgcttt tcacgttata 9180
aaatgtttat atttaccagt acagcactgg gctttataaa gactgcactc agaaccacac 9240tgcacagtcc agttttttaa aaagctgcta catgacagac aggtaatccc actgagtgag 9300ttttgagaaa caaatcaaac gaagtaaaca agaaacataa aaaccaaata gcaaatgaat 9360aaaagcctgt tcttgtaact tattcaactt ttgccaaatt cctaccaatc acttgctttt 9420taaaagaaat gtataatagc caaaagagaa attatgtccc tgttgtacag aagttagaat 9480ttttgactcc aggcagcagt ttgctcagtg atcttgaaca agttatccaa ttgcctctac 9540atttgcatca gtttctctag ctgcaaaatg gggataatac tatataccta cctcacagtg 9600ggagggcagg agattttgag gccctgaggt tttaggtggg ctgtgagggc caacgcttga 9660cacaaagtcc atgggttatt attcaagaat gcacaggccc atcggccttt tagaaagaca 9720agacagggag tgcttgtttg atatttcaag gaataaagcc ggagctcctg aattgtagtc 9780caccttaaaa gagagacctg tattggagaa tattttattt ttttggcaaa tttgatctta 9840ccctttacca gttctataat ttggttaaaa gctgattatg tcctacaatg tcaaagtcag 9900ctaactgtcg tctacttaag acttctggtc atttccaact tatagaggaa gggagtctct 9960aaaatctctt cttcagaagg cacctcactt ctcagactta aaattccaca tcaagtgttc 10020cattaaaaga agataaggca ttctgagtgc aaacaaatgg gggcttctta aactacacac 10080cagcagtcag tgaggaaaac tttgaacaat tattgagttg ctttcttggg tctctataat 10140caataacctg tctgcagata tctatctata taaagatatt atatataaat ataaatttac 10200atatatatgc acatgtatat atagttgtac atatatgtgt gtatatatat acttaaatgt 10260aatatttaca aaataaaact gtgatctcgt ctagagaaaa tgtattcata ttacaaactg 10320ctcttccata tttatgtacc atattatacc tttttattat tgttataatt attatgggta 10380tttctaatta atatgatgtt gaaacctgtt tggcaccttc tggaagctac caaaaaaatg 10440acactccatt gaagtgctta aaagctgttc tcataagaat tctactggcc tattgtaaaa 10500aagaaaaaaa aaaagaaaaa gaagaaagac acaaagaaaa taatctaaac accaaaaact 10560aaacacaatt ccaatccttt ttctgtacct cacgcgcata aatttgctgc tcctattttt 10620
ttttctgttt atgtgttttt atggatctaa gttaaatctt ttggcaatat ataaaaatgt 10680aaatagtaaa ctttatttat taagaatgtc atctttttta atttatattt acacaattgt 10740tcatctaatt tattttttct atacagtttt aaatactcag acatattttg ctgttcatga 10800tatttttatc ctgttctcat ggatttgttt tcccatactg ttttctctga tctcaattac 10860aggttggatc tcacaaataa taatgtcaga gacagaaata ttttgccact gttgattact 10920atactttaaa gttctatatt atgaaaatat ataatagctt gtacgcttca aaaaaaaaaa 10980aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa 11025<210>32<211>1627<212>PRT<213>ÈË<220>
<221>ÈÑÉïÏà¹ØÑª½¬µ°°×A<222>(1)..(1627)<223>NP002572<400>32Met Arg Leu Trp Ser Trp Val Leu His Leu Gly Leu Leu Ser Ala Ala1 5 10 15Leu Gly Cys Gly Leu Ala Glu Arg Pro Arg Arg Ala Arg Arg Asp Pro20 25 30Arg Ala Gly Arg Pro Pro Arg Pro Ala Ala Gly Pro Ala Thr Cys Ala
35 40 45Thr Arg Ala Ala Arg Gly Arg Arg Ala Ser Pro Pro Pro Pro Pro Pro50 55 60Pro Gly Gly Ala Trp Glu Ala Val Arg Val Pro Arg Arg Arg Gln Gln65 70 75 80Arg Glu Ala Arg Gly Ala Thr Glu Glu Pro Ser Pro Pro Ser Arg Ala85 90 95Leu Tyr Phe Ser Gly Arg Gly Glu Gln Leu Arg Leu Arg Ala Asp Leu100 105 110Glu Leu Pro Arg Asp Ala Phe Thr Leu Gln Val Trp Leu Arg Ala Glu115 120 125Gly Gly Gln Arg Ser Pro Ala Val Ile Thr Gly Leu Tyr Asp Lys Cys130 135 140Ser Tyr Ile Ser Arg Asp Arg Gly Trp Val Val Gly Ile His Thr Ile145 150 155 160Ser Asp Gln Asp Asn Lys Asp Pro Arg Tyr Phe Phe Ser Leu Lys Thr165 170 175Asp Arg Ala Arg Gln Val Thr Thr Ile Asn Ala His Arg Ser Tyr Leu180 185 190Pro Gly Gln Trp Val Tyr Leu Ala Ala Thr Tyr Asp Gly Gln Phe Met195 200 205Lys Leu Tyr Val Asn Gly Ala Gln Val Ala Thr Ser Gly Glu Gln Val210 215 220Gly Gly Ile Phe Ser Pro Leu Thr Gln Lys Cys Lys Val Leu Met Leu
225 230 235 240Gly Gly Ser Ala Leu Asn His Asn Tyr Arg Gly Tyr Ile Glu His Phe245 250 255Ser Leu Trp Lys Val Ala Arg Thr Gln Arg Glu Ile Leu Ser Asp Met260 265 270Glu Thr His Gly Ala His Thr Ala Leu Pro Gln Leu Leu Leu Gln Glu275 280 285Asn Trp Asp Asn Val Lys His Ala Trp Ser Pro Met Lys Asp Gly Ser290 295 300Ser Pro Lys Val Glu Phe Ser Asn Ala His Gly Phe Leu Leu Asp Thr305 310 315 320Ser Leu Glu Pro Pro Leu Cys Gly Gln Thr Leu Cys Asp Asn Thr Glu325 330 335Val Ile Ala Ser Tyr Asn Gln Leu Ser Ser Phe Arg Gln Pro Lys Val340 345 350Val Arg Tyr Arg Val Val Asn Leu Tyr Glu Asp Asp His Lys Asn Pro355 360 365Thr Val Thr Arg Glu Gln Val Asp Phe Gln His His Gln Leu Ala Glu370 375 380Ala Phe Lys Gln Tyr Asn Ile Ser Trp Glu Leu Asp Val Leu Glu Val385 390 395 400Ser Asn Ser Ser Leu Arg Arg Arg Leu Ile Leu Ala Asn Cys Asp Ile405 410 415Ser Lys Ile Gly Asp Glu Asn Cys Asp Pro Glu Cys Asn His Thr Leu
420 425 430Thr Gly His Asp Gly Gly Asp Cys Arg His Leu Arg His Pro Ala Phe435 440 445Val Lys Lys Gln His Asn Gly Val Cys Asp Met Asp Cys Asn Tyr Glu450 455 460Arg Phe Asn Phe Asp Gly Gly Glu Cys Cys Asp Pro Glu Ile Thr Asn465 470 475 480Val Thr Gln Thr Cys Phe Asp Pro Asp Ser Pro His Arg Ala Tyr Leu485 490 495Asp Val Asn Glu Leu Lys Asn Ile Leu Lys Leu Asp Gly Ser Thr His500 505 510Leu Asn Ile Phe Phe Ala Lys Ser Ser Glu Glu Glu Leu Ala Gly Val515 520 525Ala Thr Trp Pro Trp Asp Lys Glu Ala Leu Met His Leu Gly Gly Ile530 535 540Val Leu Asn Pro Ser Phe Tyr Gly Met Pro Gly His Thr His Thr Met545 550 555 560Ile His Glu Ile Gly His Ser Leu Gly Leu Tyr His Val Phe Arg Gly565 570 575Ile Ser Glu Ile Gln Ser Cys Ser Asp Pro Cys Met Glu Thr Glu Pro580 585 590Ser Phe Glu Thr Gly Asp Leu Cys Asn Asp Thr Asn Pro Ala Pro Lys595 600 605His Lys Ser Cys Gly Asp Pro Gly Pro Gly Asn Asp Thr Cys Gly Phe
610 615 620His Ser Phe Phe Asn Thr Pro Tyr Asn Asn Phe Met Ser Tyr Ala Asp625 630 635 640Asp Asp Cys Thr Asp Ser Phe Thr Pro Asn Gln Val Ala Arg Met His645 650 655Cys Tyr Leu Asp Leu Val Tyr Gln Gly Trp Gln Pro Ser Arg Lys Pro660 665 670Ala Pro Val Ala Leu Ala Pro Gln Val Leu Gly His Thr Thr Asp Ser675 680 685Val Thr Leu Glu Trp Phe Pro Pro Ile Asp Gly His Phe Phe Glu Arg690 695 700Glu Leu Gly Ser Ala Cys His Leu Cys Leu Glu Gly Arg Ile Leu Val705 710 715 720Gln Tyr Ala Ser Asn Ala Ser Ser Pro Met Pro Cys Ser Pro Ser Gly725 730 735His Trp Ser Pro Arg Glu Ala Glu Gly His Pro Asp Val Glu Gln Pro740 745 750Cys Lys Ser Ser Val Arg Thr Trp Ser Pro Asn Ser Ala Val Asn Pro755 760 765His Thr Val Pro Pro Ala Cys Pro Glu Pro Gln Gly Cys Tyr Leu Glu770 775 780Leu Glu Phe Leu Tyr Pro Leu Val Pro Glu Ser Leu Thr Ile Trp Val785 790 795 800Thr Phe Val Ser Thr Asp Trp Asp Ser Ser Gly Ala Val Asn Asp Ile
805 810 815Lys Leu Leu Ala Val Ser Gly Lys Asn Ile Ser Leu Gly Pro Gln Asn820 825 830Val Phe Cys Asp Val Pro Leu Thr Ile Arg Leu Trp Asp Val Gly Glu835 840 845Glu Val Tyr Gly Ile Gln Ile Tyr Thr Leu Asp Glu His Leu Glu Ile850 855 860Asp Ala Ala Met Leu Thr Ser Thr Ala Asp Thr Pro Leu Cys Leu Gln865 870 875 880Cys Lys Pro Leu Lys Tyr Lys Val Val Arg Asp Pro Pro Leu Gln Met885 890 895Asp Val Ala Ser Ile Leu His Leu Asn Arg Lys Phe Val Asp Met Asp900 905 910Leu Asn Leu Gly Ser Val Tyr Gln Tyr Trp Val Ile Thr Ile Ser Gly915 920 925Thr Glu Glu Ser Glu Pro Ser Pro Ala Val Thr Tyr Ile His Gly Ser930 935 940Gly Tyr Cys Gly Asp Gly Ile Ile Gln Lys Asp Gln Gly Glu Gln Cys945 950 955 960Asp Asp Met Asn Lys Ile Asn Gly Asp Gly Cys Ser Leu Phe Cys Arg965 970 975Gln Glu Val Ser Phe Asn Cys Ile Asp Glu Pro Ser Arg Cys Tyr Phe980 985 990His Asp Gly Asp Gly Val Cys Glu Glu Phe Glu Gln Lys Thr Ser Ile
995 10001005Lys Asp Cys Gly Val Tyr Thr Pro Gln Gly Phe Leu Asp Gln Trp101010151020Ala Ser Asn Ala Ser Val Ser His Gln Asp Gln Gln Cys Pro Gly102510301035Trp Val Ile Ile Gly Gln Pro Ala Ala Ser Gln Val Cys Arg Thr104010451050Lys Val Ile Asp Leu Ser Glu Gly Ile Ser Gln His Ala Trp Tyr105510601065Pro Cys Thr Ile Ser Tyr Pro Tyr Ser Gln Leu Ala Gln Thr Thr107010751080Phe Trp Leu Arg Ala Tyr Phe Ser Gln Pro Met Val Ala Ala Ala108510901095Val Ile Val His Leu Val Thr Asp Gly Thr Tyr Tyr Gly Asp Gln110011051110Lys Gln Glu Thr Ile Ser Val Gln Leu Leu Asp Thr Lys Asp Gln111511201125Ser His Asp Leu Gly Leu His Val Leu Ser Cys Arg Asn Asn Pro113011351140Leu Ile Ile Pro Val Val His Asp Leu Ser Gln Pro Phe Tyr His114511501155Ser Gln Ala Val Arg Val Ser Phe Ser Ser Pro Leu Val Ala Ile116011651170Ser Gly Val Ala Leu Arg Ser Phe Asp Asn Phe Asp Pro Val Thr
117511801185Leu Ser Ser Cys Gln Arg Gly Glu Thr Tyr Ser Pro Ala Glu Gln119011951200Ser Cys Val His Phe Ala Cys Glu Lys Thr Asp Cys Pro Glu Leu120512101215Ala Val Glu Asn Ala Ser Leu Asn Cys Ser Ser Ser Asp Arg Tyr122012251230His Gly Ala Gln Cys Thr Val Ser Cys Arg Thr Gly Tyr Val Leu123512401245Gln Ile Arg Arg Asp Asp Glu Leu Ile Lys Ser Gln Thr Gly Pro125012551260Ser Val Thr Val Thr Cys Thr Glu Gly Lys Trp Asn Lys Gln Val126512701275Ala Cys Glu Pro Val Asp Cys Ser Ile Pro Asp His His Gln Val128012851290Tyr Ala Ala Ser Phe Ser Cys Pro Glu Gly Thr Thr Phe Gly Ser129513001305Gln Cys Ser Phe Gln Cys Arg His Pro Ala Gln Leu Lys Gly Asn131013151320Asn Ser Leu Leu Thr Cys Met Glu Asp Gly Leu Trp Ser Phe Pro132513301335Glu Ala Leu Cys Glu Leu Met Cys Leu Ala Pro Pro Pro Val Pro134013451350Asn Ala Asp Leu Gln Thr Ala Arg Cys Arg Glu Asn Lys His Lys
135513601365Val Gly Ser Phe Cys Lys Tyr Lys Cys Lys Pro Gly Tyr His Val137013751380Pro Gly Ser Ser Arg Lys Ser Lys Lys Arg Ala Phe Lys Thr Gln138513901395Cys Thr Gln Asp Gly Ser Trp Gln Glu Gly Ala Cys Val Pro Val140014051410Thr Cys Asp Pro Pro Pro Pro Lys Phe His Gly Leu Tyr Gln Cys141514201425Thr Asn Gly Phe Gln Phe Asn Ser Glu Cys Arg Ile Lys Cys Glu143014351440Asp Ser Asp Ala Ser Gln Gly Leu Gly Ser Asn Val Ile His Cys144514501455Arg Lys Asp Gly Thr Trp Asn Gly Ser Phe His Val Cys Gln Glu146014651470Met Gln Gly Gln Cys Ser Val Pro Asn Glu Leu Asn Ser Asn Leu147514801485Lys Leu Gln Cys Pro Asp Gly Tyr Ala Ile Gly Ser Glu Cys Ala149014951500Thr Ser Cys Leu Asp His Asn Ser Glu Ser Ile Ile Leu Pro Met150515101515Asn Val Thr Val Arg Asp Ile Pro His Trp Leu Asn Pro Thr Arg152015251530Val Glu Arg Val Val Cys Thr Ala Gly Leu Lys Trp Tyr Pro His
153515401545Pro Ala Leu Ile His Cys Val Lys Gly Cys Glu Pro Phe Met Gly155015551560Asp Asn Tyr Cys Asp Ala Ile Asn Asn Arg Ala Phe Cys Asn Tyr156515701575Asp Gly Gly Asp Cys Cys Thr Ser Thr Val Lys Thr Lys Lys Val158015851590Thr Pro Phe Pro Met Ser Cys Asp Leu Gln Gly Asp Cys Ala Cys159516001605Arg Asp Pro Gln Ala Gln Glu His Ser Arg Lys Asp Leu Arg Gly161016151620Tyr Ser His Gly1625<210>33<211>2444<212>DNA<213>ÈË<220>
<221>¶¡õ£µ¨¼îõ¥Ã¸<222>(1)..(2444)<223>NM000055
<400>33agtaacagtt gattgttaca ttcagtaaca ctgaatgtca gtgcagtcca atttacaggc 60tggagcagca gctgcatcct gcatttcccc gaagtattac atgattttca ctccttgcaa120actttaccat ctttgttgca gagaatcgga aatcaatatg catagcaaag tcacaatcat180atgcatcaga tttctctttt ggtttctttt gctctgcatg cttattggga agtcacatac240tgaagatgac atcataattg caacaaagaa tggaaaagtc agagggatga acttgacagt300ttttggtggc acggtaacag cctttcttgg aattccctat gcacagccac ctcttggtag360acttcgattc aaaaagccac agtctctgac caagtggtct gatatttgga atgccacaaa420atatgcaaat tcttgctgtc agaacataga tcaaagtttt ccaggcttcc atggatcaga480gatgtggaac ccaaacactg acctcagtga agactgttta tatctaaatg tatggattcc540agcacctaaa ccaaaaaatg ccactgtatt gatatggatt tatggtggtg gttttcaaac600tggaacatca tctttacatg tttatgatgg caagtttctg gctcgggttg aaagagttat660tgtagtgtca atgaactata gggtgggtgc cctaggattc ttagctttgc caggaaatcc720tgaggctcca gggaacatgg gtttatttga tcaacagttg gctcttcagt gggttcaaaa780aaatatagca gcctttggtg gaaatcctaa aagtgtaact ctctttggag aaagtgcagg840agcagcttca gttagcctgc atttgctttc tcctggaagc cattcattgt tcaccagagc900cattctgcaa agtggatcct ttaatgctcc ttgggcggta acatctcttt atgaagctag960gaacagaacg ttgaacttag ctaaattgac tggttgctct agagagaatg agactgaaat 1020aatcaagtgt cttagaaata aagatcccca agaaattctt ctgaatgaag catttgttgt 1080cccctatggg actcctttgt cagtaaactt tggtccgacc gtggatggtg attttctcac 1140tgacatgcca gacatattac ttgaacttgg acaatttaaa aaaacccaga ttttggtggg 1200tgttaataaa gatgaaggga cagctttttt agtctatggt gctcctggct tcagcaaaga 1260taacaatagt atcataacta gaaaagaatt tcaggaaggt ttaaaaatat tttttccagg 1320agtgagtgag tttggaaagg aatccatcct ttttcattac acagactggg tagatgatca 1380
gagacctgaa aactaccgtg aggccttggg tgatgttgtt ggggattata atttcatatg 1440ccctgccttg gagttcacca agaagttctc agaatgggga aataatgcct ttttctacta 1500ttttgaacac cgatcctcca aacttccgtg gccagaatgg atgggagtga tgcatggcta 1560tgaaattgaa tttgtctttg gtttacctct ggaaagaaga gataattaca caaaagccga 1620ggaaattttg agtagatcca tagtgaaacg gtgggcaaat tttgcaaaat atgggaatcc 1680aaatgagact cagaacaata gcacaagctg gcctgtcttc aaaagcactg aacaaaaata 1740tctaaccttg aatacagagt caacaagaat aatgacgaaa ctacgtgctc aacaatgtcg 1800attctggaca tcattttttc caaaagtctt ggaaatgaca ggaaatattg atgaagcaga 1860atgggagtgg aaagcaggat tccatcgctg gaacaattac atgatggact ggaaaaatca 1920atttaacgat tacactagca agaaagaaag ttgtgtgggt ctctaattaa tagatttacc 1980ctttatagaa catattttcc tttagatcaa ggcaaaaata tcaggagctt ttttacacac 2040ctactaaaaa agttattatg tagctgaaac aaaaatgcca gaaggataat attgattcct 2100cacatcttta acttagtatt ttacctagca tttcaaaacc caaatggcta gaacatgttt 2160aattaaattt cacaatataa agttctacag ttaattatgt gcatattaaa acaatggcct 2220ggttcaattt ctttctttcc ttaataaatt taagtttttt ccccccaaaa ttatcagtgc 2280tctgctttta gtcacgtgta ttttcattac cactcgtaaa aaggtatctt ttttaaatga 2340attaaatatt gaaacactgt acaccatagt ttacaatatt atgtttccta attaaaataa 2400gaattgaatg tcaatatgag atattaaaat aagcacagaa aatc2444<210>34<211>602<212>PRT<213>ÈË
<220>
<221>¶¡õ£µ¨¼îõ¥Ã¸<222>(1)..(602)<223>NP000046<400> 34Met His Ser Lys Val Thr Ile Ile Cys Ile Arg Phe Leu Phe Trp Phe1 5 10 15Leu Leu Leu Cys Met Leu Ile Gly Lys Ser His Thr Glu Asp Asp Ile20 25 30Ile Ile Ala Thr Lys Asn Gly Lys Val Arg Gly Met Asn Leu Thr Val35 40 45Phe Gly Gly Thr Val Thr Ala Phe Leu Gly Ile Pro Tyr Ala Gln Pro50 55 60Pro Leu Gly Arg Leu Arg Phe Lys Lys Pro Gln Ser Leu Thr Lys Trp65 70 75 80Ser Asp Ile Trp Asn Ala Thr Lys Tyr Ala Asn Ser Cys Cys Gln Asn85 90 95Ile Asp Gln Ser Phe Pro Gly Phe His Gly Ser Glu Met Trp Asn Pro100 105 110Asn Thr Asp Leu Ser Glu Asp Cys Leu Tyr Leu Asn Val Trp Ile Pro115 120 125Ala Pro Lys Pro Lys Asn Ala Thr Val Leu Ile Trp Ile Tyr Gly Gly130 135 140
Gly Phe Gln Thr Gly Thr Ser Ser Leu His Val Tyr Asp Gly Lys Phe145 150 155 160Leu Ala Arg Val Glu Arg Val Ile Val Val Ser Met Asn Tyr Arg Val165 170 175Gly Ala Leu Gly Phe Leu Ala Leu Pro Gly Asn Pro Glu Ala Pro Gly180 185 190Asn Met Gly Leu Phe Asp Gln Gln Leu Ala Leu Gln Trp Val Gln Lys195 200 205Asn Ile Ala Ala Phe Gly Gly Asn Pro Lys Ser Val Thr Leu Phe Gly210 215 220Glu Ser Ala Gly Ala Ala Ser Val Ser Leu His Leu Leu Ser Pro Gly225 230 235 240Ser His Ser Leu Phe Thr Arg Ala Ile Leu Gln Ser Gly Ser Phe Asn245 250 255Ala Pro Trp Ala Val Thr Ser Leu Tyr Glu Ala Arg Asn Arg Thr Leu260 265 270Asn Leu Ala Lys Leu Thr Gly Cys Ser Arg Glu Asn Glu Thr Glu Ile275 280 285Ile Lys Cys Leu Arg Asn Lys Asp Pro Gln Glu Ile Leu Leu Asn Glu290 295 300Ala Phe Val Val Pro Tyr Gly Thr Pro Leu Ser Val Asn Phe Gly Pro305 310 315 320Thr Val Asp Gly Asp Phe Leu Thr Asp Met Pro Asp Ile Leu Leu Glu325 330 335
Leu Gly Gln Phe Lys Lys Thr Gln Ile Leu Val Gly Val Asn Lys Asp340 345 350Glu Gly Thr Ala Phe Leu Val Tyr Gly Ala Pro Gly Phe Ser Lys Asp355 360 365Asn Asn Ser Ile Ile Thr Arg Lys Glu Phe Gln Glu Gly Leu Lys Ile370 375 380Phe Phe Pro Gly Val Ser Glu Phe Gly Lys Glu Ser Ile Leu Phe His385 390 395 400Tyr Thr Asp Trp Val Asp Asp Gln Arg Pro Glu Asn Tyr Arg Glu Ala405 410 415Leu Gly Asp Val Val Gly Asp Tyr Asn Phe Ile Cys Pro Ala Leu Glu420 425 430Phe Thr Lys Lys Phe Ser Glu Trp Gly Asn Asn Ala Phe Phe Tyr Tyr435 440 445Phe Glu His Arg Ser Ser Lys Leu Pro Trp Pro Glu Trp Met Gly Val450 455 460Met His Gly Tyr Glu Ile Glu Phe Val Phe Gly Leu Pro Leu Glu Arg465 470 475 480Arg Asp Asn Tyr Thr Lys Ala Glu Glu Ile Leu Ser Arg Ser Ile Val485 490 495Lys Arg Trp Ala Asn Phe Ala Lys Tyr Gly Asn Pro Asn Glu Thr Gln500 505 510Asn Asn Ser Thr Ser Trp Pro Val Phe Lys Ser Thr Glu Gln Lys Tyr515 520 525
Leu Thr Leu Asn Thr Glu Ser Thr Arg Ile Met Thr Lys Leu Arg Ala530 535 540Gln Gln Cys Arg Phe Trp Thr Ser Phe Phe Pro Lys Val Leu Glu Met545 550 555 560Thr Gly Asn Ile Asp Glu Ala Glu Trp Glu Trp Lys Ala Gly Phe His565 570 575Arg Trp Asn Asn Tyr Met Met Asp Trp Lys Asn Gln Phe Asn Asp Tyr580 585 590Thr Ser Lys Lys Glu Ser Cys Val Gly Leu595 600<210>35<211>1150<212>DNA<213>ÈË<220>
<221>ÄÚÆ¤Äý¼¯ËØHL-2<222>(1)..(1150)<223>NM080878<400>35gcaggggagc tccgagtgtc cacaggaagg gaactatcag ctcctggcat ctgtaaggat 60gctgtccatg ctgaggacaa tgaccagact ctgcttcctg ttattcttct ctgtggccac120
cagtgggtgc agtgcagcag cagcctcttc tcttgagatg ctctcgaggg aattcgaaac180ctgtgccttc tccttttctt ccctgcctag aagctgcaaa gaaatcaagg aacgctgcca240tagtgcaggt gatggcctgt attttctccg caccaagaat ggtgttgtct accagacctt300ctgtgacatg acttctgggg gtggcggctg gaccctggtg gccagcgtgc acgagaatga360catgcgtggg aagtgcacgg tgggtgatcg ctggtccagt cagcagggca acaaagcaga420ctacccagag ggggatggca actgggccaa ctacaacacc tttggatctg cagaggcggc480cacgagcgat gactacaaga accctggcta ctacgacatc caggccaagg acctgggcat540ctggcatgtg cccaacaagt cccccatgca gcattggaga aacagcgccc tgctgaggta600ccgcaccaac actggcttcc tccagagact gggacataat ctgtttggca tctaccagaa660atacccagtg aaatacagat cagggaaatg ttggaatgac aatggcccag ccatacctgt720ggtctatgac tttggtgatg ctaagaagac tgcatcttat tactcaccgt atggtcaacg780ggaatttgtt gcaggattcg ttcagttccg ggtgtttaat aacgagagag cagccaacgc840cctttgtgct gggataaaag ttactggctg taacactgag catcactgca tcggtggagg900agggttcttc ccacagggca aaccccgtca gtgtggggac ttctccgcct ttgactggga960tggatatgga actcacgtta agagcagctg cagtcgggag ataacggagg cggctgtact 1020cttgttctat agatgagaca gagctctgcg gtgtcagggc gagaacccat cttccaaccc 1080cggctatttg gagacggaaa aactggaatt ctaacaagga ggagaggaga ctaaatcaca 1140tcaatttgca 1150<210>36<211>325<212>PRT<213>ÈË
<220>
<221>ÄÚÆ¤Äý¾ÛËØHL-2<222>(1)..(325)<223>NP543154<400>36Met Leu Ser Met Leu Arg Thr Met Thr Arg Leu Cys Phe Leu Leu Phe1 5 10 15Phe Ser Val Ala Thr Ser Gly Cys Ser Ala Ala Ala Ala Ser Ser Leu20 25 30Glu Met Leu Ser Arg Glu Phe Glu Thr Cys Ala Phe Ser Phe Ser Ser35 40 45Leu Pro Arg Ser Cys Lys Glu Ile Lys Glu Arg Cys His Ser Ala Gly50 55 60Asp Gly Leu Tyr Phe Leu Arg Thr Lys Asn Gly Val Val Tyr Gln Thr65 70 75 80Phe Cys Asp Met Thr Ser Gly Gly Gly Gly Trp Thr Leu Val Ala Ser85 90 95Val His Glu Asn Asp Met Arg Gly Lys Cys Thr Val Gly Asp Arg Trp100 105 110Ser Ser Gln Gln Gly Asn Lys Ala Asp Tyr Pro Glu Gly Asp Gly Asn115 120 125Trp Ala Asn Tyr Asn Thr Phe Gly Ser Ala Glu Ala Ala Thr Ser Asp130 135 140
Asp Tyr Lys Asn Pro Gly Tyr Tyr Asp Ile Gln Ala Lys Asp Leu Gly145 150 155 160Ile Trp His Val Pro Asn Lys Ser Pro Met Gln His Trp Arg Asn Ser165 170 175Ala Leu Leu Arg Tyr Arg Thr Asn Thr Gly Phe Leu Gln Arg Leu Gly180 185 190His Asn Leu Phe Gly Ile Tyr Gln Lys Tyr Pro Val Lys Tyr Arg Ser195 200 205Gly Lys Cys Trp Asn Asp Asn Gly Pro Ala Ile Pro Val Val Tyr Asp210 215 220Phe Gly Asp Ala Lys Lys Thr Ala Ser Tyr Tyr Ser Pro Tyr Gly Gln225 230 235 240Arg Glu Phe Val Ala Gly Phe Val Gln Phe Arg Val Phe Asn Asn Glu245 250 255Arg Ala Ala Asn Ala Leu Cys Ala Gly Ile Lys Val Thr Gly Cys Asn260 265 270Thr Glu His His Cys Ile Gly Gly Gly Gly Phe Phe Pro Gln Gly Lys275 280 285Pro Arg Gln Cys Gly Asp Phe Ser Ala Phe Asp Trp Asp Gly Tyr Gly290 295 300Thr His Val Lys Ser Ser Cys Ser Arg Glu Ile Thr Glu Ala Ala Val305 310 315 320Leu Leu Phe Tyr Arg325
<210>37<211>2085<212>DNA<213>ÈË<220>
<221>¾ÞºËϸ°ûÔöÇ¿Òò×ÓǰÌå<222>(1)..(2085)<223>NM005823<400>37tggccactcc cgtctgctgt gacgcgcgga cagagagcta ccggtggacc cacggtgcct 60ccctccctgg gatctacaca gaccatggcc ttgccaacgg ctcgacccct gttggggtcc120tgtgggaccc ccgccctcgg cagcctcctg ttcctgctct tcagcctcgg atgggtgcag180ccctcgagga ccctggctgg agagacaggg caggaggctg cacccctgga cggagtcctg240gccaacccac ctaacatttc cagcctctcc cctcgccaac tccttggctt cccgtgtgcg300gaggtgtccg gcctgagcac ggagcgtgtc cgggagctgg ctgtggcctt ggcacagaag360aatgtcaagc tctcaacaga gcagctgcgc tgtctggctc accggctctc tgagcccccc420gaggacctgg acgccctccc attggacctg ctgctattcc tcaacccaga tgcgttctcg480gggccccagg cctgcacccg tttcttctcc cgcatcacga aggccaatgt ggacctgctc540ccgagggggg ctcccgagcg acagcggctg ctgcctgcgg ctctggcctg ctggggtgtg600cgggggtctc tgctgagcga ggctgatgtg cgggctctgg gaggcctggc ttgcgacctg660cctgggcgct ttgtggccga gtcggccgaa gtgctgctac cccggctggt gagctgcccg720
ggacccctgg accaggacca gcaggaggca gccagggcgg ctctgcaggg cgggggaccc780ccctacggcc ccccgtcgac atggtctgtc tccacgatgg acgctctgcg gggcctgctg840cccgtgctgg gccagcccat catccgcagc atcccgcagg gcatcgtggc cgcgtggcgg900caacgctcct ctcgggaccc atcctggcgg cagcctgaac ggaccatcct ccggccgcgg960ttccggcggg aagtggagaa gacagcctgt ccttcaggca agaaggcccg cgagatagac 1020gagagcctca tcttctacaa gaagtgggag ctggaagcct gcgtggatgc ggccctgctg 1080gccacccaga tggaccgcgt gaacgccatc cccttcacct acgagcagct ggacgtccta 1140aagcataaac tggatgagct ctacccacaa ggttaccccg agtctgtgat ccagcacctg 1200ggctacctct tcctcaagat gagccctgag gacattcgca agtggaatgt gacgtccctg 1260gagaccctga aggctttgct tgaagtcaac aaagggcacg aaatgagtcc tcaggtggcc 1320accctgatcg accgctttgt gaagggaagg ggccagctag acaaagacac cctagacacc 1380ctgaccgcct tctaccctgg gtacctgtgc tccctcagcc ccgaggagct gagctccgtg 1440ccccccagca gcatctgggc ggtcaggccc caggacctgg acacgtgtga cccaaggcag 1500ctggacgtcc tctatcccaa ggcccgcctt gctttccaga acatgaacgg gtccgaatac 1560ttcgtgaaga tccagtcctt cctgggtggg gcccccacgg aggatttgaa ggcgctcagt 1620cagcagaatg tgagcatgga cttggccacg ttcatgaagc tgcggacgga tgcggtgctg 1680ccgttgactg tggctgaggt gcagaaactt ctgggacccc acgtggaggg cctgaaggcg 1740gaggagcggc accgcccggt gcgggactgg atcctacggc agcggcagga cgacctggac 1800acgctggggc tggggctaca gggcggcatc cccaacggct acctggtcct agacctcagc 1860gtgcaagagg ccctctcggg gacgccctgc ctcctaggac ctggacctgt tctcaccgtc 1920ctggcactgc tcctagcctc caccctggcc tgagggcccc actcccttgc tggccccagc 1980cctgctgggg atccccgcct ggccaggagc aggcacgggt gatccccgtt ccaccccaag 2040agaactcgcg ctcagtaaac gggaacatgc cccctgcaga cacgt 2085
<210>38<211>622<212>PRT<213>ÈË<220>
<221>¾ÞºËϸ°ûÔöÇ¿Òò×ÓǰÌå<222>(1)..(622)<223>NP005814<400>38Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro1 5 10 15Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln20 25 30Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu35 40 45Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg50 55 60Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu65 70 75 80Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu85 90 95Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro
100 105 110Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro115 120 125Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile130 135 140Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln145 150 155 160Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu165 170 175Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu180 185 190Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu195 200 205Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg210 215 220Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp225 230 235 240Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly245 250 255Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg260 265 270Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile275 280 285Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser
290 295 300Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys305 310 315 320Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met325 330 335Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu340 345 350Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val355 360 365Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile370 375 380Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu385 390 395 400Val Asn Lys Gly His Glu Met Ser Pro Gln Val Ala Thr Leu Ile Asp405 410 415Arg Phe Val Lys Gly Arg Gly Gln Leu Asp Lys Asp Thr Leu Asp Thr420 425 430Leu Thr Ala Phe Tyr Pro Gly Tyr Leu Cys Ser Leu Ser Pro Glu Glu435 440 445Leu Ser Ser Val Pro Pro Ser Ser Ile Trp Ala Val Arg Pro Gln Asp450 455 460Leu Asp Thr Cys Asp Pro Arg Gln Leu Asp Val Leu Tyr Pro Lys Ala465 470 475 480Arg Leu Ala Phe Gln Asn Met Asn Gly Ser Glu Tyr Phe Val Lys Ile
485 490 495Gln Ser Phe Leu Gly Gly Ala Pro Thr Glu Asp Leu Lys Ala Leu Ser500 505 510Gln Gln Asn Val Ser Met Asp Leu Ala Thr Phe Met Lys Leu Arg Thr515 520 525Asp Ala Val Leu Pro Leu Thr Val Ala Glu Val Gln Lys Leu Leu Gly530 535 540Pro His Val Glu Gly Leu Lys Ala Glu Glu Arg His Arg Pro Val Arg545 550 555 560Asp Trp Ile Leu Arg Gln Arg Gln Asp Asp Leu Asp Thr Leu Gly Leu565 570 575Gly Leu Gln Gly Gly Ile Pro Asn Gly Tyr Leu Val Leu Asp Leu Ser580 585 590Val Gln Glu Ala Leu Ser Gly Thr Pro Cys Leu Leu Gly Pro Gly Pro595 600 605Val Leu Thr Val Leu Ala Leu Leu Leu Ala Ser Thr Leu Ala610 615 620
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